Social and Behavioral Sciences Commons^™

Measuring Allostatic Load In An Urban Adolescent Sample: The Profile And Role Of Biomarker Dysregulation In Depression Outcomes, Heather Marshall

College of Science and Health Theses and Dissertations

Accumulated, chronic stress exposure is well established as a precursor for allostatic load (AL). Both stress exposure and AL have been associated with depression in the existing literature. While many studies have focused on biomarkers representative of various physiological systems, a clear understanding of how physiological AL results in depression is yet unclear. Further, variability of hypo- and hypercortisolemic profiles have been associated with depression. A review of the existing literature supports hypocortisolemic profiles in relation to female depression and hypercortisolemic profiles in male depression across both adolescent and adult populations. The function of alpha-amylase (AA) dysregulation within the context …