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Full-Text Articles in Social and Behavioral Sciences
The Effects Of Lipopolysaccharide On Positive Reinforcement In Rats, Daamoon Ghahari
The Effects Of Lipopolysaccharide On Positive Reinforcement In Rats, Daamoon Ghahari
2018 Undergraduate Awards
Lipopolysaccharide (LPS), a bacterial endotoxin which has potent immune activating properties, has been widely used to study the effects of neuroinflammation in animal models. Previous studies have demonstrated that LPS increases the stress response, reduces operant responding, and causes anhedonia and anorexia in rats. Most of these studies have demonstrated the behavioural effects of LPS through decreases in palatable solution consumption or self-administration of pleasurable electrical brain stimulation (EBS), however a more detailed study exploring the differences between appetitive and consummatory behaviours is needed to truly understand the impact of neuroinflammation on food-motivated behaviour. The current study injected 23 male …
Anorexic And Forgetting Effects Of Lipopolysaccharide On Positive Reinforcement In Rats, Mahdieh Varvani Farahani
Anorexic And Forgetting Effects Of Lipopolysaccharide On Positive Reinforcement In Rats, Mahdieh Varvani Farahani
2018 Undergraduate Awards
It is widely demonstrated that lipopolysaccharide (LPS), a gram-negative bacteria derived endotoxin, induces symptoms that present similar to a stress response, commonly referred to as ‘sickness behaviours’. The purpose of this study was to examine the effects of LPS on learnt food motivated behaviours in rats by analyzing bar pressing behaviours in a Skinner box under an FR-1 schedule. 23 male Long Evans rats were injected with either 200 μg/kg LPS (n = 8), 1 mg/kg of scopolamine hydrobromide (a known memory blocker; n = 7), or a saline control injection (n = 8). Prior to injection, rats were taught …
Individual Differences In Impulsivity And Mesocorticolimbic Connectivity Strength In Pre-Adolescence, Daamoon Ghahari
Individual Differences In Impulsivity And Mesocorticolimbic Connectivity Strength In Pre-Adolescence, Daamoon Ghahari
2018 Undergraduate Awards
Individual differences in pre-adolescent impulsivity, or the preference for smaller immediate rewards over larger delayed rewards, has been related to a multitude of outcomes measured later in life, such as physical and psychological health, substance dependence, financial well-being, academic achievement, social adjustment, and criminal behaviour. The mesocorticolimbic dopamine pathway (MCLP), a neural circuitry involved in reward motivated behaviours and decision-making, has been extensively linked to the delay discounting task, an effective tool for quantifying trait impulsivity. While previous research has demonstrated a negative correlation between the structural connectivity strength of the right dorsolateral prefrontal tract and the functional activity of …