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Full-Text Articles in Social and Behavioral Sciences
A Bi Strategy To Deliver Actionable Insights And Improve Decision Making At University Of Wollongong, Craig Napier
A Bi Strategy To Deliver Actionable Insights And Improve Decision Making At University Of Wollongong, Craig Napier
Senior Deputy Vice-Chancellor and Deputy Vice-Chancellor (Education) - Papers
In 1999 the University of Wollongong embarked on a BI initiative through the establishment of a BI Centre of Excellence. With a vision to improve University performance through enhancing business decisions, UOW has delivered a comprehensive suite of strategic reporting and improved the transparency, availability and dissemination of information by breaking down operational silos. Today a revitalised view of BI takes effect that extends and builds upon this strong foundation that has uncovered hidden insights. The session will explore; The redefined BI strategy that supports the strategic plan The importance of visualisations to deliver actionable insights Leveraging our assets to …
Navigating Terrain And Discovering Insights Into Uows Sphere Of Influence, Craig Napier
Navigating Terrain And Discovering Insights Into Uows Sphere Of Influence, Craig Napier
Senior Deputy Vice-Chancellor and Deputy Vice-Chancellor (Education) - Papers
The Performance Indicators Unit is utilising its strong analytical foundation and is extending their BI capabilities into areas of prescriptive analytics. Rather that reporting on what has happened we must inform and influence what will happen which is a dramatic shift. With a robust analytical foundation the opportunity to leverage these assets is the new focus that is providing insights into the extent, strength and interactions of our complex relationships.
Allosteric Activation Transitions In Enzymes And Biomolecular Motors: Insights From Atomistic And Coarse-Grained Simulations, Michael D. Daily, Haibo Yu, George N. Phillips, Qiang Cui
Allosteric Activation Transitions In Enzymes And Biomolecular Motors: Insights From Atomistic And Coarse-Grained Simulations, Michael D. Daily, Haibo Yu, George N. Phillips, Qiang Cui
Faculty of Science, Medicine and Health - Papers: part A
The chemical step in enzymes is usually preceded by a kinetically distinct activation step that involves large-scale conformational transitions. In "simple" enzymes this step corresponds to the closure of the active site; in more complex enzymes, such as biomolecular motors, the activation step is more complex and may involve interactions with other biomolecules. These activation transitions are essential to the function of enzymes and perturbations in the scale and/or rate of these transitions are implicated in various serious human diseases; incorporating key flexibilities into engineered enzymes is also considered a major remaining challenge in rational enzyme design. Therefore it is …
Considerations For U-Series Dating Of Sediments: Insights From The Flinders Ranges, South Australia, Heather K. Handley, Simon P. Turner, Anthony Dosseto, David Haberlah, Juan C. Afonso
Considerations For U-Series Dating Of Sediments: Insights From The Flinders Ranges, South Australia, Heather K. Handley, Simon P. Turner, Anthony Dosseto, David Haberlah, Juan C. Afonso
Faculty of Science, Medicine and Health - Papers: part A
Uranium isotope ratios have been determined for the fine-grained detrital fraction of Pleistocene Wilkawillina valley-fill sediments, four local Proterozoic bedrock samples and fine-grained aeolian material from a sand dune deposit of the Flinders Ranges, South Australia. The aim was to quantify the comminution age, i.e. the time elapsed since physical weathering of the bedrock, and residence time of the valley-fill sediments and to place tighter constraints on input parameters for the comminution age calculation. Despite using two independent approaches for determination of the recoil lost fraction of 234U from the sediment (weighted geometric and surface area estimates), samples fail to …
Comment On "Accordion Vs. Quantum Tectonics: Insights Into Continental Growth Processes From The Paleozoic Of Eastern Gondwana" By Jonathan C. Aitchison, Solomon Buckman Gondwana Research, Volume 22, Issue 2, September 2012, Pages 674-680, C L. Fergusson
Faculty of Science, Medicine and Health - Papers: part A
In regard to the tectonic history of the Lachlan Fold Belt, Aitchison and Buckman (2012) argued that "numerous aspects of the observed geology appear to be incompatible with the existing model" and that an "alternative model envisages arc-continent collision events (quantum tectonics) as a primary means of large-scale continental growth". My purpose is to challenge these arguments and to question their interpretation that rapid continental growth in the Lachlan Fold Belt has been achieved by thrusting of an island arc over a passive margin.
Structural Insights Into Omega-Class Glutathione Transferases: A Snapshot Of Enzyme Reduction And Identification Of A Non-Catalytic Ligandin Site, Joseph Brock, Philip G. Board, Aaron J. Oakley
Structural Insights Into Omega-Class Glutathione Transferases: A Snapshot Of Enzyme Reduction And Identification Of A Non-Catalytic Ligandin Site, Joseph Brock, Philip G. Board, Aaron J. Oakley
Faculty of Science, Medicine and Health - Papers: part A
Glutathione transferases (GSTs) are dimeric enzymes containing one active-site per monomer. The omega-class GSTs (hGSTO1-1 and hGSTO2-2 in humans) are homodimeric and carry out a range of reactions including the glutathione-dependant reduction of a range of compounds and the reduction of S-(phenacyl)glutathiones to acetophenones. Both types of reaction result in the formation of a mixed-disulfide of the enzyme with glutathione through the catalytic cysteine (C32). Recycling of the enzyme utilizes a second glutathione molecule and results in oxidized glutathione (GSSG) release. The crystal structure of an active-site mutant (C32A) of the hGSTO1-1 isozyme in complex with GSSG provides a snapshot …