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Articles 1 - 6 of 6
Full-Text Articles in Social and Behavioral Sciences
The Small Heat-Shock Protein Αb-Crystallin Uses Different Mechanisms Of Chaperone Action To Prevent The Amorphous Versus Fibrillar Aggregation Of Α-Lactalbumin, Melissa Kulig, Heath Ecroyd
The Small Heat-Shock Protein Αb-Crystallin Uses Different Mechanisms Of Chaperone Action To Prevent The Amorphous Versus Fibrillar Aggregation Of Α-Lactalbumin, Melissa Kulig, Heath Ecroyd
Faculty of Science, Medicine and Health - Papers: part A
Stress conditions can destabilize proteins, promoting them to unfold and adopt intermediately folded states. Partially folded protein intermediates are unstable and prone to aggregation down off-folding pathways leading to the formation of either amorphous or amyloid fibril aggregates. The sHsp (small heat-shock protein) αB-crystallin acts as a molecular chaperone to prevent both amorphous and fibrillar protein aggregation; however, the precise molecular mechanisms behind its chaperone action are incompletely understood. To investigate whether the chaperone activity of αB-crystallin is dependent upon the form of aggregation (amorphous compared with fibrillar), bovine α-lactalbumin was developed as a model target protein that could be …
Dissociation Of Erk Signalling Inhibition From The Anti-Amyloidogenic Action Of Synthetic Ceramide Analogues, Hongyun Li, Genevieve Evin, Andrew F. Hill, Ya Hui Hung, Ashley I. Bush, Brett Garner
Dissociation Of Erk Signalling Inhibition From The Anti-Amyloidogenic Action Of Synthetic Ceramide Analogues, Hongyun Li, Genevieve Evin, Andrew F. Hill, Ya Hui Hung, Ashley I. Bush, Brett Garner
Faculty of Science - Papers (Archive)
Inhibition of GSL (glycosphingolipid) synthesis reduces Aβ (amyloid β-peptide) production in vitro. Previous studies indicate that GCS (glucosylceramide synthase) inhibitors modulate phosphorylation of ERK1/2 (extracellular-signal-regulated kinase 1/2) and that the ERK pathway may regulate some aspects of Aβ production. It is not clear whether there is a causative relationship linking GSL synthesis inhibition, ERK phosphorylation and Aβ production. In the present study, we treated CHO cells (Chinese-hamster ovary cells) and SH-SY5Y neuroblastoma cells, that both constitutively express human wild-type APP (amyloid precursor protein) and process this to produce Aβ, with GSL-modulating agents to explore this relationship. We found that three …
Preparing Action Competent Environmental Educators: How Hard Could It Be?, Wendy Nielsen, Peter Andersen, Amy Hurley, Vanessa Sabljak, Amy-Lee Petereit, Vanessa Hoskin, Garry Hoban
Preparing Action Competent Environmental Educators: How Hard Could It Be?, Wendy Nielsen, Peter Andersen, Amy Hurley, Vanessa Sabljak, Amy-Lee Petereit, Vanessa Hoskin, Garry Hoban
Faculty of Social Sciences - Papers (Archive)
This article describes an interpretive study that evaluated a new subject in teacher education called 'Education for Sustainable Development'. The study evaluated the subject for its ability to prepare pre-service teachers for their roles as environmental educators. We used perspectives in place-based pedagogy and critical thinking to underpin the subject design and our analysis. Data sources include instructor journals, planning documents, interviews with students and student thinking books. Interpretive analysis of the data corpus was a collaborative process that involved both subject instructors and students who took the subject. Themes that emerged from the research were centred around: (1) how …
Participatory Action Research: Relevance And Use For Contemporary Nursing Research, Lorna Moxham
Participatory Action Research: Relevance And Use For Contemporary Nursing Research, Lorna Moxham
Faculty of Science, Medicine and Health - Papers: part A
This paper will demonstrate how, using a collaborative, inclusive research methodology, positive impacts on clinical practice and enhanced client outcomes can be achieved.
Doing Participatory Action Research And Doing A Phd: Words Of Encouragement For Prospective Students, Natascha Klocker
Doing Participatory Action Research And Doing A Phd: Words Of Encouragement For Prospective Students, Natascha Klocker
Faculty of Science - Papers (Archive)
No abstract provided.
Will Climate Severity Ever Lead To Climate Action? Implications For Adaptation Policy And Practice, Bastian Seidel, Erica Bell
Will Climate Severity Ever Lead To Climate Action? Implications For Adaptation Policy And Practice, Bastian Seidel, Erica Bell
Faculty of Science, Medicine and Health - Papers: part A
No abstract provided.