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Full-Text Articles in Social and Behavioral Sciences
Dissociation Of Erk Signalling Inhibition From The Anti-Amyloidogenic Action Of Synthetic Ceramide Analogues, Hongyun Li, Genevieve Evin, Andrew F. Hill, Ya Hui Hung, Ashley I. Bush, Brett Garner
Dissociation Of Erk Signalling Inhibition From The Anti-Amyloidogenic Action Of Synthetic Ceramide Analogues, Hongyun Li, Genevieve Evin, Andrew F. Hill, Ya Hui Hung, Ashley I. Bush, Brett Garner
Faculty of Science - Papers (Archive)
Inhibition of GSL (glycosphingolipid) synthesis reduces Aβ (amyloid β-peptide) production in vitro. Previous studies indicate that GCS (glucosylceramide synthase) inhibitors modulate phosphorylation of ERK1/2 (extracellular-signal-regulated kinase 1/2) and that the ERK pathway may regulate some aspects of Aβ production. It is not clear whether there is a causative relationship linking GSL synthesis inhibition, ERK phosphorylation and Aβ production. In the present study, we treated CHO cells (Chinese-hamster ovary cells) and SH-SY5Y neuroblastoma cells, that both constitutively express human wild-type APP (amyloid precursor protein) and process this to produce Aβ, with GSL-modulating agents to explore this relationship. We found that three …
Doing Participatory Action Research And Doing A Phd: Words Of Encouragement For Prospective Students, Natascha Klocker
Doing Participatory Action Research And Doing A Phd: Words Of Encouragement For Prospective Students, Natascha Klocker
Faculty of Science - Papers (Archive)
No abstract provided.
Corrigendum To ‘‘The Chaperone Action Of Bovine Milk As1- And As2-Caseins And Their Associated Form As-Casein’’ [Arch. Biochem. Biophys. 510 (2011) 42–52], Teresa M. Treweek, David C. Thorn, William E. Price, John A. Carver
Corrigendum To ‘‘The Chaperone Action Of Bovine Milk As1- And As2-Caseins And Their Associated Form As-Casein’’ [Arch. Biochem. Biophys. 510 (2011) 42–52], Teresa M. Treweek, David C. Thorn, William E. Price, John A. Carver
Faculty of Science - Papers (Archive)
No abstract provided.
Catalytic Solar Water Splitting Inspired By Photosynthesis. Homogeneous Catalysts With A Mechanical ("Machine-Like") Action, Gerhard F. Swiegers, G Charles Dismukes, Leone Spiccia, Robin Brimblecombe, Annette Koo, Jun Chen, Gordon G. Wallace
Catalytic Solar Water Splitting Inspired By Photosynthesis. Homogeneous Catalysts With A Mechanical ("Machine-Like") Action, Gerhard F. Swiegers, G Charles Dismukes, Leone Spiccia, Robin Brimblecombe, Annette Koo, Jun Chen, Gordon G. Wallace
Faculty of Science - Papers (Archive)
Chemical reactions may be controlled by either: the minimum threshold energy that must be overcome during collisions between reactant molecules / atoms (the Activation Energy, Ea), or: the rate at which reactant collisions occur (the Collision Frequency, A) (for reactions with low Ea). Reactions of type (2) are governed by the physical, mechanical interaction of the reactants. Such mechanical processes are unusual, but not unknown in molecular catalysts. We examine the catalytic action and macroscopic properties of several abiological mechanical catalysts and show that they display distinct similarities to enzymes in general. An abiological model of the Photosystem II Water …
Toxicity, Biotransformation, And Mode Of Action Of Arsenic In Two Freshwater Microalgae (Chlorella Sp. And Monoraphidium Arcuatum), Jacqueline L. Levy, Jennifer L. Stauber, Merrin S. Adams, William A. Maher, Jason K. Kirby, Dianne F. Jolley
Toxicity, Biotransformation, And Mode Of Action Of Arsenic In Two Freshwater Microalgae (Chlorella Sp. And Monoraphidium Arcuatum), Jacqueline L. Levy, Jennifer L. Stauber, Merrin S. Adams, William A. Maher, Jason K. Kirby, Dianne F. Jolley
Faculty of Science - Papers (Archive)
The toxicity of As(V) and As(III) to two axenic tropical 15 freshwater microalgae, Chlorella sp. and Monoraphidium arcuatum, was determined using 72-h growth rate inhibition bioassays. Both organisms were tolerant to As(III) (72-h IC50, concentration to cause 50% inhibition of growth, of 25 and 15 mg As(III)/L, respectively). Chlorella sp. was also tolerant to As(V) with no effect on growth rate over 72 h at concentrations up to 0.8 mg/L (72-h IC50 of 25 mg As(V)/L). M. arcuatum was more sensitive to As(V) (72-h IC50 of 0.25 mg As(V)/L). An increase in phosphate in the growth medium (0.15 to 1.5 …