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Source Estimation Of The Reward Positivity And Related Resting State Network Activity In Major Depressive Disorder, Christopher J.H. Pirrung

Psychology ETDs

Anhedonia is a complex symptom of Major Depressive Disorder (MDD) that presents itself through multiple behavioral phenotypes of diminished reward processing. In order to better understand this deficit, we aim to look at a marker of reward that is sensitive to information content and valence, the Reward Positivity (RewP). The source of this signal is, however, up for debate. This study used concurrent EEG and MEG to establish the source of the RewP as a distributed network involving ventromedial prefrontal cortex (vmPFC), anterior midcingulate cortex (aMCC), and insulae. Additionally, only vmPFC showed a deficit in MDD. fMRI resting state functional …