Social and Behavioral Sciences Commons^™

Conformation Dependent Monoclonal Antibodies Distinguish Different Replicating Strains Or Conformers Of Prefibrillar Aβ Oligomers, Rakez Kayed, Isabel Canto, Leonid Breydo, Suhail Rasool, Tamas Lukacsovich, Jessica Wu, Ricardo Albay, Anna Pensalfini, Stephen Yeung, Elizabeth Head, J. Lawrence Marsh, Charles Glabe

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Age-related neurodegenerative diseases share a number of important pathological features, such as accumulation of misfolded proteins as amyloid oligomers and fibrils. Recent evidence suggests that soluble amyloid oligomers and not the insoluble amyloid fibrils may represent the primary pathological species of protein aggregates.

RESULTS: We have produced several monoclonal antibodies that specifically recognize prefibrillar oligomers and do not recognize amyloid fibrils, monomer or natively folded proteins. Like the polyclonal antisera, the individual monoclonals recognize generic epitopes that do not depend on a specific linear amino acid sequence, but they display distinct preferences for different subsets of prefibrillar oligomers. Immunological …

A Model Of The Information Seeking And Decision Making Of Online Coin Buyers, Donald O. Case

Information Science Faculty Publications

Introduction. The Everyday Life Information Seeking approach suggests that much information behaviour takes place in non-work settings, for example in the pursuit of leisure activities such as hobbies. This study focuses on a community of collectors to examine how they gather information to decide whether to purchase an item for their collection when the target item has an ambiguous or deficient description.

Method. Manual scanning of eBay and other online discussion board for coin buyers led to 187 postings indicating an attempt to reach a purchase decision, or to authenticate a purchased coin, through solicitation or posting of advice.

Analysis. …

Archivists’ Toolkit Collaboration, Kathryn Lybarger

Library Presentations

No abstract provided.

Criminal Offending Among Respondents To Protective Orders: Crime Types And Patterns That Predict Victim Risk, Carol E. Jordan, Adam J. Pritchard, Danielle Duckett, Richard Charnigo

Office for Policy Studies on Violence Against Women Publications

Research has shown that respondents to protective orders have robust criminal histories and that criminal offending behavior often follows issuance of a protective order. Nonetheless, the specific nature of the association between protective orders and criminal offending remains unclear. This study uses two classes of statistical models to more clearly delineate that relationship. The models reveal factors and characteristics that appear to be associated with offending and protective order issuance and provide indications about when a victim is most at risk and when the justice system should be most ready to provide immediate protection.

Networks Of European Cities In Worlds Of Global Economic And Environmental Change, Stanley D. Brunn, Lomme Devriendt, Andrew Boulton, Ben Derudder, Frank Witlox

Geography Faculty Publications

Geographers have a long tradition of classifying cities using a number of criteria. Population size, industrial production, capital city functions, airline connections, sites of sporting events and major headquarters and banks are among them. While these studies are useful in looking at cities in an economy and population at a given point of time, they are less useful in assessing rapidly occurring changes within a regional or global system. Our research represents a new approach to classify cities and urban systems; we use the volume and networks/linkages or flows associated with electronic Information or “Knowledge worlds.” We argue that in …

Saving Student Brian: Engaging Students With Innovative Technology, Stacey Greenwell, Beth Kraemer, Debbie Sharp, Susan K. Smith

Library Faculty and Staff Publications

Question: How do you provide library orientation for a large number of first-year students without boring them to death? Answer: Create a video using new technology, student actors, and a little fun.

Learn step by step how the University of Kentucky Libraries revived their first year student orientation experience creating a video filmed on campus and in the virtual world, Second Life. From writing and filming to editing and screening, the presenters will discuss the process, offering practical tips and suggestions for creating your own instructional video. In addition, the presenters will discuss lessons learned from this experience.

The Us Preventive Service Taskforce And The Guide To Clinical Preventive Services., F. Douglas Scutchfield Md

Preventive Medicine and Environmental Health Presentations

No abstract provided.

Community Health Assesments, F. Douglas Scutchfield Md

Preventive Medicine and Environmental Health Presentations

No abstract provided.

Caveat Emptor: It May Be Electronic, But Don’T Overlook The Fine Print, Stephanie N. Aken

Library Presentations

No abstract provided.

Public Health Services And Systems Research: Data For Research, F. Douglas Scutchfield Md

Preventive Medicine and Environmental Health Presentations

No abstract provided.

Southeastern Law Librarian Fall 2010, Seaall

Newsletters

No abstract provided.

Managing Faculty And Student Expectations At The Circulation Desk, Jennifer A. Bartlett

Library Presentations

Work at main circulation desks in large academic and public libraries involves the ability to manage increasing service demands from patrons, colleagues, and the organization's administration. The perception of circulation as a catch-all department, handling responsibilities that do not fit neatly into other areas, can make this work feel like "emptying the litter pan." This presentation discusses the importance of circulation as the professional face of the library and its centrality to effective and efficient library service in the face of challenges involving mission, perception, and funding.

The Appalachian Regional Development Act And Economic Change, James P. Ziliak

University of Kentucky Center for Poverty Research Discussion Paper Series

The Appalachian Regional Development Act of 1965 is one of the longest serving place-based regional development programs in the U.S., and is the largest in terms of geographic scope. I use county-level data from the 1960 thru 2000 Decennial Censuses to evaluate the effect of ARDA on poverty rates and real per capita incomes in Appalachia. The intent to treat parameter is identified in a difference-in-difference-in-difference framework by comparing outcomes in Appalachia to her border counties. Additional knowledge of which counties were solely eligible for highway development funds under ARDA from those counties eligible for both highway as well as …

Deficient Liver Biosynthesis Of Docosahexaenoic Acid Correlates With Cognitive Impairment In Alzheimer's Disease, Giuseppe Astarita, Kwang-Mook Jung, Nicole C. Berchtold, Vinh Q. Nguyen, Daniel L. Gillen, Elizabeth Head, Carl W. Cotman, Daniele Piomelli

Sanders-Brown Center on Aging Faculty Publications

Reduced brain levels of docosahexaenoic acid (C22:6n-3), a neurotrophic and neuroprotective fatty acid, may contribute to cognitive decline in Alzheimer's disease. Here, we investigated whether the liver enzyme system that provides docosahexaenoic acid to the brain is dysfunctional in this disease. Docosahexaenoic acid levels were reduced in temporal cortex, mid-frontal cortex and cerebellum of subjects with Alzheimer's disease, compared to control subjects (P = 0.007). Mini Mental State Examination (MMSE) scores positively correlated with docosahexaenoic/α-linolenic ratios in temporal cortex (P = 0.005) and mid-frontal cortex (P = 0.018), but not cerebellum. Similarly, liver docosahexaenoic acid content was lower in Alzheimer's …

Hosted/Hybrid: The Uk-Iarhives Production Model, Kopana Terry

Library Presentations

No abstract provided.

Does Race Based Redistricting Matter For Policy?, Ebonya Washington

University of Kentucky Center for Poverty Research Discussion Paper Series

During the 1990 congressional redistricting many states were mandated to create additional majority minority-resident districts in order to elect more minorities to Congress. Civil rights groups and Republicans cheered. The Party views Democratic districts stripped of Black voters as opportunities to repaint blue districts red. The academic literature agrees, attributing the Republican return to House control in 1994 to race based redistricting. However, this literature generally focuses on the district as the unit of analysis, a focus that is too narrow, as some districts gain Black residents while others lose them. I focus on states, the level at which redistricting …

Poverty, Inequality And Cost Of Living Differences, Enrico Moretti

University of Kentucky Center for Poverty Research Discussion Paper Series

Metropolitan areas in the US are characterized by enormous differences in average income, earnings, and factor productivity. The income of individuals located in metropolitan areas at the top of the income distribution is more than double the income of observationally similar individuals located in metropolitan areas at the bottom of the distribution. These differences reflect, at least in part, variation in local productivity.

Southeastern Law Librarian Summer 2010, Seaall

Newsletters

No abstract provided.

Batch Editing Marc Records With Marcedit And Regular Expressions, Kathryn Lybarger, Julene L. Jones

Library Presentations

No abstract provided.

Iaald 2.0: Integrating Social Networking Into A Traditional Professional Organization, Antoinette Paris Greider

Library Presentations

No abstract provided.

Relationship And Injury Trends In The Homicide Of Women Across The Lifespan: A Research Note, Carol E. Jordan, Adam J. Pritchard, Danielle Duckett, Pamela Wilcox, Tracey Corey, Mandy Combest

Office for Policy Studies on Violence Against Women Publications

In 2006, more than 3,600 women in the United States lost their lives to homicide. Descriptive data regarding homicides of women are beginning to reveal important complexities regarding victim–offender relationships, severity of injury, and age of female homicide victim. More specifically, there is some indication that the correlation between victim–offender relationship and injury severity may be conditional, depending on victim age. This retrospective review accessed medical examiner records of female homicide victims from 2002 through 2004, and its findings offer additional illumination on the trends in associations of injury and relationship variables in the homicide of women over their life …

The Impact Of U.S. Family Planning Programs On Fertility And Mortality: Evidence From The War On Poverty And Title X, Martha Bailey

University of Kentucky Center for Poverty Research Discussion Paper Series

Over forty years ago, the U.S. government adopted a policy of funding domestic family planning services, and the effects of these programs have been debated ever since. Within an event-study framework, I exploit community-level variation in the timing of federal grants for family planning services under the Economic Opportunity Act (1965 to 1974) and Title X (1970 to 1980) to evaluate their impact. The results provide robust evidence that federal family planning grants reduced birth rates in funded communities by four percent within six years. I find no evidence that family planning grants reduced maternal or infant mortality rates.

Southeastern Law Librarian Spring 2010, Seaall

Newsletters

No abstract provided.

How Do You Know What You Don't Know? Digital Preservation Education, Mary H. Molinaro

Library Faculty and Staff Publications

As the amount of digital information held in digital libraries proliferates, how does the the library community insure that best practices and standards for digital preservation are followed so that this content persists in time? The problems increase as more and more practictioners are creating content with no knowledge of what tools and practices are needed to create sustainable content. This article suggests a model that could serve as a way forward.

[Review Of] A Cultural Dictionary Of Punk, Robert A. Aken

Library Faculty and Staff Publications

No abstract provided.

Omega-3 Fatty Acids: Potential Role In The Management Of Early Alzheimer's Disease, Gregory A. Jicha, William R. Markesbery

Sanders-Brown Center on Aging Faculty Publications

Omega-3 fatty acids are essential for brain growth and development. They play an important role throughout life, as critical modulators of neuronal function and regulation of oxidative stress mechanisms, in brain health and disease. Docosahexanoic acid (DHA), the major omega-3 fatty acid found in neurons, has taken on a central role as a target for therapeutic intervention in Alzheimer's disease (AD). A plethora of in vitro, animal model, and human data, gathered over the past decade, highlight the important role DHA may play in the development of a variety of neurological and psychiatric disorders, including AD. Cross sectional and prospective …

A Conceptual Framework Of Information Requirements For Scientists Using Human Biological Samples, Sujin Kim

Information Science Faculty Publications

Introduction. This study was undertaken to develop an information requirement framework for scientists who use biological samples and related data in their research.

Method. A self-reporting questionnaire completed by 137 respondents was used to collect data regarding demographics, bio-sample management, bio-sample use and requirements, data requirements, and work and research-related roles and activities.

Analysis. Descriptive and TwoStep Cluster analyses were used to analyse the survey data necessary for developing a framework of information requirements.

Results. Two groups of biomedical scientists (clinical group and basic scientist group) were formed by their distinct characteristics. A conceptual framework of information requirements for bio-sample …

Lexical Analysis, Andrew R. Hippisley

Linguistics Faculty Publications

No abstract provided.

Notes On Poverty Traps And Appalachia, Steven Durlauf

University of Kentucky Center for Poverty Research Discussion Paper Series

In these notes, I provide some general ideas on how to conceptualize poverty traps and speculate on their applicability to understanding Appalachian poverty. My goal is to stimulate thinking on Appalachia that exploits contemporary perspectives in economics on the sources of persistent poverty and inequality. To do this, I focus on both the theory of poverty traps as well as issues in the econometric assessment of their empirical salience.

Assessing The Impact Of A Modernized Application Process On Florida’S Food Stamp Caseload, Colleen Heflin, Peter Mueser

University of Kentucky Center for Poverty Research Discussion Paper Series

In 2005, Florida implemented an internet-based service delivery system for eligibility determination in public assistance programs, including the Food Stamp, Temporary Assistance for Needy Families (TANF), and the Medicaid programs. At the same time, Florida switched from a caseworker model to a technology-driven model and decreased staffing levels of employees involved in social service delivery. We conduct an evaluative case study of the effects of these policy changes on the Food Stamp caseload. In particular, we consider the impact on applications and the flows onto and off of the program. To answer these questions, we use administrative data from the …