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Full-Text Articles in Social and Behavioral Sciences
An Analysis Of Neurogenesis In A Mouse Model Of Chemotherapy Related Cognitive Impairment, Maxwell A. Hennings
An Analysis Of Neurogenesis In A Mouse Model Of Chemotherapy Related Cognitive Impairment, Maxwell A. Hennings
Electronic Theses and Dissertations
Cancer patients treated with adjuvant chemotherapy often experience cognitive decline following treatment. This phenomenon, often dubbed “chemo brain” or “chemo fog” is usually temporary, but for a subset of survivors, these cognitive impairments can be long-lasting (>10 years) and negatively affect patients’ quality of life, career performance, and social fulfillment. While it is unclear what neurobiological mechanisms underlie chemotherapy related cognitive impairment, the majority of the animal literature has focused on adult neurogenesis. One process important for neurogenesis is the proliferation of new neurons within the dentate gyrus of the hippocampus. It is evident that many chemotherapy agents can …
The Long-Term Impact Of Chemotherapy On Neurogenesis And The Potential Use Of Fluoxetine As Preventative Treatment, Margaret Ross
The Long-Term Impact Of Chemotherapy On Neurogenesis And The Potential Use Of Fluoxetine As Preventative Treatment, Margaret Ross
Honors College
The present study attempts to investigate a potential underlying mechanism that contributes to cognitive impairments associated with chemotherapy treatment. In addition, it looks to investigate the potential preventative treatment using an antidepressant agent (Fluoxetine) to reduce the effects observed by chemotherapy treatment. One proposed explanation for Chemo Brain is a reduction in the proliferation of new brain cells. This study was designed to investigate this mechanism and was conducted in a series of two experiments. In experiment 1, 37 C57BL/6J male mice were administered saline or one of two chemotherapy agents; Cyclophosphamide or Doxorubicin over the course of eight days. …
Long Term Effects Of Chemotherapy On Cognition, Preventative Potential Of Antidepressants, Ryan Hall
Long Term Effects Of Chemotherapy On Cognition, Preventative Potential Of Antidepressants, Ryan Hall
Honors College
Each year, over 1.6 million people in the U.S. alone will be diagnosed with some form of cancer. With advances in treatment, survival rates have risen to nearly 65%. While remission and survival are the ultimate goals of treatment, it has become clear that many cancer survivors (estimates range from 15% to 70%) treated with chemotherapy experience significant, long-lasting cognitive impairment. This chemotherapy associated cognitive impairment is often called "Chemo Fog" or "Chemo Brain." For some, the effects are mild, such as having difficulty with focusing, concentrating, and speed of processing. For others, the cognitive impairments can be significant and …