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Social and Behavioral Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Singapore Management University

2001

Medicine and Health Sciences

Sequential trials

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Full-Text Articles in Social and Behavioral Sciences

Optimal Designs For Evaluating A Series Of Treatments, Denis H. Y. Leung, You Gan Wang Mar 2001

Optimal Designs For Evaluating A Series Of Treatments, Denis H. Y. Leung, You Gan Wang

Research Collection School Of Economics

Several articles in this journal have studied optimal designs for testing a series of treatments to identify promising ones for further study. These designs formulate testing as an ongoing process until a promising treatment is identified. This formulation is considered to be more realistic but substantially increases the computational complexity. In this article, we show that these new designs, which control the error rates for a series of treatments, can be reformulated as conventional designs that control the error rates for each individual treatment. This reformulation leads to a more meaningful interpretation of the error rates and hence easier specification …