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Articles 1 - 30 of 46
Full-Text Articles in Social and Behavioral Sciences
Networked Human, Network’S Human: Humans In Networks Inter-Asia, Eric Kerr, Connor Graham, Alfred Montoya
Networked Human, Network’S Human: Humans In Networks Inter-Asia, Eric Kerr, Connor Graham, Alfred Montoya
Alfred Montoya
This special issue explores the conceptions of the human that emerge out of the form and the design of information and communications technologies (ICTs). Geographically, our focus compares two countries with a relatively high level of ICT penetration—South Korea and Singapore—and two countries with a relatively low level—India and Vietnam. In each country we see how different forms of the human emerge, in part out of the ways in which technological infrastructure develop and intertwine with social order. In this introduction we reflect on the long genealogy of “human” and “humanity” and the more recent history of ICTs in Asia.
The Force Of Absent Things: Hiv/Aids, Pepfar Vietnam, And The Afterlife Of Aid, Alfred Montoya
The Force Of Absent Things: Hiv/Aids, Pepfar Vietnam, And The Afterlife Of Aid, Alfred Montoya
Alfred Montoya
This article examines emerging strategies employed by nongovernmental organizations working in HIV/AIDS prevention and control in Vietnam that have been put to work in the recent past in the context of precipitous declines in US funding for such work through the President’s Emergency Plan for AIDS Relief (PEPFAR). These strategies foreground specific personalities in an instrumentalization of experience, expert knowledges, and identity in a delicate balance between projecting strength and indicating urgent need. These strategies are played out in the realm of social media, facilitated through information communications technologies (ICTs) that are quickly restructuring forms of sociality and the tradecraft …
Right Parietal Cortex Mediates Recognition Memory For Melodies, Nora K. Schaal, Amir-Homayoun Javadi, Andrea Halpern, Bettina Pollok, Michael J. Banissy
Right Parietal Cortex Mediates Recognition Memory For Melodies, Nora K. Schaal, Amir-Homayoun Javadi, Andrea Halpern, Bettina Pollok, Michael J. Banissy
Andrea Halpern
Functional brain imaging studies have highlighted the significance of right-lateralized temporal, frontal and parietal brain areas for memory for melodies. The present study investigated the involvement of bilateral posterior parietal cortices (PPCs) for the recognition memory of melodies using transcranial direct current stimulation (tDCS). Participants performed a recognition task before and after tDCS. The task included an encoding phase (12 melodies), a retention period, as well as a recognition phase (24 melodies). Experiment 1 revealed that anodal tDCS over the right PPC led to a deterioration of overall memory performance compared with sham. Experiment 2 confirmed the results of Experiment …
Mindfulness-Based Emotional Intelligence Training: A New Approach To Reducing Human Suffering And Promoting Effectiveness, John Blackledge, Joseph Ciarrochi
Mindfulness-Based Emotional Intelligence Training: A New Approach To Reducing Human Suffering And Promoting Effectiveness, John Blackledge, Joseph Ciarrochi
joseph Ciarrochi
No abstract provided.
Path Integration Deficits During Linear Locomotion After Human Medial Temporal Lobectomy, John W. Philbeck, Marlene Behrmann, Lucien Levy, Samuel J. Potolicchio, Anthony J. Caputy
Path Integration Deficits During Linear Locomotion After Human Medial Temporal Lobectomy, John W. Philbeck, Marlene Behrmann, Lucien Levy, Samuel J. Potolicchio, Anthony J. Caputy
Marlene Behrmann
Animal navigation studies have implicated structures in and around the hippocampal formation as crucial in performing path integration (a method of determining one's position by monitoring internally generated self-motion signals). Less is known about the role of these structures for human path integration. We tested path integration in patients who had undergone left or right medial temporal lobectomy as therapy for epilepsy. This procedure removed approximately 50% of the anterior portion of the hippocampus, as well as the amygdala and lateral temporal lobe. Participants attempted to walk without vision to a previously viewed target 2-6 m distant. Patients with right, …
Muscles Within Muscles: A Mechanomyographic Analysis Of Muscle Segment Contractile Properties Within Human Gluteus Maximus, Darryl Mcandrew, John Brown, Mark Gorelick
Muscles Within Muscles: A Mechanomyographic Analysis Of Muscle Segment Contractile Properties Within Human Gluteus Maximus, Darryl Mcandrew, John Brown, Mark Gorelick
Darryl J McAndrew
No abstract provided.
The Relationship Between Isometric Force-Time Curve Characteristics And Club Head Speed In Recreational Golfers, Brian K. Leary, Jason Statler, Brent Hopkins, Rachel Fitzwater, Tucker Kesling, Jacob Lyon, Brent Phillips, Randall Bryner, Prue Cormie, Guy Haff
The Relationship Between Isometric Force-Time Curve Characteristics And Club Head Speed In Recreational Golfers, Brian K. Leary, Jason Statler, Brent Hopkins, Rachel Fitzwater, Tucker Kesling, Jacob Lyon, Brent Phillips, Randall Bryner, Prue Cormie, Guy Haff
Greg Haff
The relationship between isometric force-time curve characteristics and club head speed in recreational golfers. J Strength Cond Res 26(10): 2685-2697, 2012-The primary purpose of the present investigation was to examine the relationships between club head speed, isometric midthigh pull performance, and vertical jump performance in a cohort of recreational golfers. Twelve recreational golfers (age, 20.4 ± 1.0 years; weight, 77.0 ± 9.8 kg; height, 177.8 ± 6.3 cm; body fat, 17.1 ± 7.6%; handicap, 14.5 ± 7.3; experience, 8.9 ± 3.6 years) completed 3 testing sessions: (a) familiarization session and body composition measurements; (b) measurement of forcetime curves in the …
The Acute Effects Of Moderately Loaded Concentric-Only Quarter Squats On Vertical Jump Performance, Aaron Crum, Naoki Kawamori, Michael Stone, Guy Haff
The Acute Effects Of Moderately Loaded Concentric-Only Quarter Squats On Vertical Jump Performance, Aaron Crum, Naoki Kawamori, Michael Stone, Guy Haff
Greg Haff
2012-Limited research exists examining the effect of moderately loaded conditioning activities that are employed as part of a strength-power potentiating complex (SPPC). Additionally, no studies to date have explored the effects of using a concentric-only quarter back squat protocol as part of an SPPC. Therefore, the purpose of this study was to examine the effects of a moderately loaded (50-65% of 1RM) concentric-only quarter back squat protocol on the occurrence of potentiation effects at various time points. Twenty men who could quarter back squat a minimum of 2.4 times their body mass (3.7 ±: 0.7 kg-per body mass) participated in …
The Yo-Yo Ir2 Test: Physiological Response, Reliability, And Application To Elite Soccer, Lisa Oberacker, Shala Davis, Guy Haff, Chad Witmer, Gavin Moir
The Yo-Yo Ir2 Test: Physiological Response, Reliability, And Application To Elite Soccer, Lisa Oberacker, Shala Davis, Guy Haff, Chad Witmer, Gavin Moir
Greg Haff
The purpose of this study was to compare the effects of resistance training performed on either a stable or unstable surface on performance tests in female soccer players. Nineteen National Collegiate Athletic Association Division II female soccer players were assigned to either an unstable training group (UST: 19.0±0.47 years; 1.6966.4 m; 67.8±7.7kg) or a stable training group (ST: 19.6 ± 0.49 years; 1.64 ± 3.2 m; 62.7 ± 6.27 kg). Player positions were distributed evenly between the groups. Both the groups followed a 5-week periodized resistance training program designed to develop maximum muscular strength. The groups performed the same exercises …
The Relationship Between Isometric Force-Time Curve Characteristics And Club Head Speed In Recreational Golfers, Brian K. Leary, Jason Statler, Brent Hopkins, Rachel Fitzwater, Tucker Kesling, Jacob Lyon, Brent Phillips, Randall Bryner, Prue Cormie, Guy Haff
The Relationship Between Isometric Force-Time Curve Characteristics And Club Head Speed In Recreational Golfers, Brian K. Leary, Jason Statler, Brent Hopkins, Rachel Fitzwater, Tucker Kesling, Jacob Lyon, Brent Phillips, Randall Bryner, Prue Cormie, Guy Haff
Prue Cormie
The relationship between isometric force-time curve characteristics and club head speed in recreational golfers. J Strength Cond Res 26(10): 2685-2697, 2012-The primary purpose of the present investigation was to examine the relationships between club head speed, isometric midthigh pull performance, and vertical jump performance in a cohort of recreational golfers. Twelve recreational golfers (age, 20.4 ± 1.0 years; weight, 77.0 ± 9.8 kg; height, 177.8 ± 6.3 cm; body fat, 17.1 ± 7.6%; handicap, 14.5 ± 7.3; experience, 8.9 ± 3.6 years) completed 3 testing sessions: (a) familiarization session and body composition measurements; (b) measurement of forcetime curves in the …
Inertial Sensing For Human Motor Control Symmetry In Injury Rehabilitation, Matthew Field, David Stirling, Montserrat Ros, Zengxi Stephen Pan, Fazel Naghdy
Inertial Sensing For Human Motor Control Symmetry In Injury Rehabilitation, Matthew Field, David Stirling, Montserrat Ros, Zengxi Stephen Pan, Fazel Naghdy
zengxi pan
This paper proposes a series of methods for representing changes in human motion during injury rehabilitation using Micro-Electro-Mechanical Systems (MEMS) inertial sensors. Tracking the changes over a recovery period requires methods for evaluating the similarity of movement in an impaired state against a non-impaired state. We investigate the use of motion analyses such as the centre of mass (COM) tipping distance, the variance of joint velocity eigenvalues and the cumulative state changes of Gaussian mixture models (GMM) for monitoring the symmetry between the left and right sides of body during rehabilitation exercises. The methods are tested on an injured athlete …
Do Patient-Reported Androgen-Deprivation Therapy Side Effects Predict Anxiety And Depression Among Prostate Cancer Patients Undergoing Radiotherapy? Implications For Psychosocial Therapy Interventions, Christopher Sharpley, Vicki Bitsika, David Christie
Do Patient-Reported Androgen-Deprivation Therapy Side Effects Predict Anxiety And Depression Among Prostate Cancer Patients Undergoing Radiotherapy? Implications For Psychosocial Therapy Interventions, Christopher Sharpley, Vicki Bitsika, David Christie
Vicki Bitsika
Antiandrogen therapy (AAT) is a common adjunct treatment for prostate cancer (PCa) patients and has shown significant benefits to long-term outcomes from radiation or surgery. Although AAT has some adverse side effects and data from breast cancer patients indicate that such side effects from hormonal therapies may contribute to anxiety and depression and may also hinder AAT treatment compliance, this issue has not been investigated within a sample of PCa patients. This study explores the incidence of AAT side effects in a sample of PCa patients, the links between those side effects and anxiety and depression, the possible ways in …
Earthly Indifference And Human Difference - Book Review, Lesley Head
Earthly Indifference And Human Difference - Book Review, Lesley Head
Lesley Head
Inspired by, but also in reaction to the flattened topologies of Latourian relationality, Clark puts forward the notion of radical asymmetry. 'This is the bottom line of human being: we are utterly dependent on an earth and a cosmos that is, to a large degree, indifferent to us' (p. 50). With their disciplinary connection to the physical and natural sciences, geographers arguably need this lesson less than other social scientists. We should have learned it well from geologists who, spending their working lives in deepest time, tend to have a less anthropocentric perspective than others (perhaps accounting for their disproportionate …
Defining The Structural Basis Of Human Plasminogen Binding By Streptococcal Surface Enolase, Amanda J. Cork, Slobodan Jergic, Sven Hammerschmidt, Bostjan Kobe, Vijay Pancholi, Justin L.P. Benesch, Carol V, Robinson, Nicholas E. Dixon, J Andrew Aquilina, Mark J. Walker
Defining The Structural Basis Of Human Plasminogen Binding By Streptococcal Surface Enolase, Amanda J. Cork, Slobodan Jergic, Sven Hammerschmidt, Bostjan Kobe, Vijay Pancholi, Justin L.P. Benesch, Carol V, Robinson, Nicholas E. Dixon, J Andrew Aquilina, Mark J. Walker
Professor Nick E Dixon
The flesh-eating bacterium group A Streptococcus (GAS) binds and activates human plasminogen, promoting invasive disease. Streptococcal surface enolase (SEN), a glycolytic pathway enzyme, is an identified plasminogen receptor of GAS. Here we used mass spectrometry (MS) to confirm that GAS SEN is octameric, thereby validating in silico modeling based on the crystal structure of S. pneumoniae -enolase. Site-directed mutagenesis of surface-located lysine residues (SENK252+255A, SENK304A, SENK334A, SENK344E, SENK435L and SEN434-435) was used to examine their roles in maintaining structural integrity, enzymatic function and plasminogen binding. Structural integrity of the GAS SEN octamer was retained for all mutants except SENK344E, as …
Identification Of Human Plasma Proteins As Major Clients For The Extracellular Chaperone Clusterin, Amy R. Wyatt, Mark R. Wilson
Identification Of Human Plasma Proteins As Major Clients For The Extracellular Chaperone Clusterin, Amy R. Wyatt, Mark R. Wilson
Mark R Wilson
Clusterin (CLU) is an extracellular chaperone that is likely to play an important role in protein folding quality control. This study identified three deposition disease-associated proteins as major plasma clients for clusterin by studying CLU-client complexes formed in response to physiologically relevant stress (shear stress, similar to 36 dynes/cm(2) at 37 degrees C). Analysis of plasma samples by size exclusion chromatography indicated that (i) relative to control plasma, stressed plasma contained proportionally more soluble protein species of high molecular weight, and (ii) high molecular weight species were far more abundant when proteins purified by anti-CLU immunoaffinity chromatography from stressed plasma …
Defining The Functional Properties Of Dietary Protein And Protein-Rich Foods In Human Energy Expenditure, Sze Yen Tan, Linda Tapsell, Marijka Batterham, Karen Charlton
Defining The Functional Properties Of Dietary Protein And Protein-Rich Foods In Human Energy Expenditure, Sze Yen Tan, Linda Tapsell, Marijka Batterham, Karen Charlton
Karen E. Charlton
Food has a number of functional properties that can support the balance between energy intake and energy expenditure and, theoretically, one of these is the thermic effect of food. Including high-protein foods in meals may be advantageous in contributing to energy expenditure but, in practice, the evidence needs to relate to specific foods and normal dietary conditions. Using the human whole room calorimeter facility, we conducted three studies to examine the effects of: (i) higher and lower levels of protein on energy expenditure; (ii) high-protein meals using different foods to deliver the protein; and (iii) omnivorous and vegetarian cuisines in …
Sediment Mixing At Nonda Rock: Investigations Of Stratigraphic Integrity At An Early Archaeological Site In Northern Australia And Implications For The Human Colonisation Of The Continent, Richard Roberts, C White, L K Fifield, Christian Turney, M Bird, John Tibby, Bruno David, John Magee, Jerome Mialanes
Sediment Mixing At Nonda Rock: Investigations Of Stratigraphic Integrity At An Early Archaeological Site In Northern Australia And Implications For The Human Colonisation Of The Continent, Richard Roberts, C White, L K Fifield, Christian Turney, M Bird, John Tibby, Bruno David, John Magee, Jerome Mialanes
Richard G Roberts
No abstract provided.
Late-Surviving Megafauna In Tasmania Australia, Implicate Human Involvement In Their Extinction, Christian Turney, T Flannery, Richard Roberts, Craig Reid, Keith Fifield, T Higham, Zenobia Jacobs, Noel Kemp, Eric Colhoun, R.M. Kalin
Late-Surviving Megafauna In Tasmania Australia, Implicate Human Involvement In Their Extinction, Christian Turney, T Flannery, Richard Roberts, Craig Reid, Keith Fifield, T Higham, Zenobia Jacobs, Noel Kemp, Eric Colhoun, R.M. Kalin
Richard G Roberts
Establishing the cause of past extinctions is critical if we are to understand better what might trigger future occurrences and how to prevent them. The mechanisms of continental late Pleistocene megafaunal extinction, however, are still fiercely contested. Potential factors contributing to their demise include climatic change, human impact, or some combination. On the Australian mainland, 90% of the megafauna became extinct by ≈46 thousand years (ka) ago, soon after the first archaeological evidence for human colonization of the continent. Yet, on the neighboring island of Tasmania (which was connected to the mainland when sea levels were lower), megafaunal extinction appears …
Human Occupation, Adaptation And Behavioural Change In The Pleistocene And Holocene Of South India: Recent Investigations In The Kurnool District, Andhra Pradesh, Richard Roberts, Kevin White, Christopher Clarkson, Jinu Koshy, Ravi Korisettar, Sacha Jones, Clive Oppenheimer, Nicole Boivin, Michael Petraglia, Peter Ditchfield, Janardhana B, Jamie Hampson, Preston Miracle, Kevin Cunningham, M Kasturi Bai, Dorian Fuller, Michael Haslam
Human Occupation, Adaptation And Behavioural Change In The Pleistocene And Holocene Of South India: Recent Investigations In The Kurnool District, Andhra Pradesh, Richard Roberts, Kevin White, Christopher Clarkson, Jinu Koshy, Ravi Korisettar, Sacha Jones, Clive Oppenheimer, Nicole Boivin, Michael Petraglia, Peter Ditchfield, Janardhana B, Jamie Hampson, Preston Miracle, Kevin Cunningham, M Kasturi Bai, Dorian Fuller, Michael Haslam
Richard G Roberts
No abstract provided.
Establishing The Time Of Initial Human Occupation Of Liang Bua, Western Flores, Indonesia, Kira Westaway, Michael Morwood, Richard Roberts, J Zhao, T. Sutikna, E.W. Saptomo, W Rink
Establishing The Time Of Initial Human Occupation Of Liang Bua, Western Flores, Indonesia, Kira Westaway, Michael Morwood, Richard Roberts, J Zhao, T. Sutikna, E.W. Saptomo, W Rink
Richard G Roberts
No abstract provided.
Single-Grain Osl Chronologies For Middle Palaeolithic Deposits At El Mnasra And El Harhoura 2, Morocco: Implications For Late Pleistocene Human-Environment Interactions Along The Atlantic Coast Of Northwest Africa, Zenobia Jacobs, Richard Roberts, Roland Nespoulet, M El Hajraoui, Andre Debenath
Single-Grain Osl Chronologies For Middle Palaeolithic Deposits At El Mnasra And El Harhoura 2, Morocco: Implications For Late Pleistocene Human-Environment Interactions Along The Atlantic Coast Of Northwest Africa, Zenobia Jacobs, Richard Roberts, Roland Nespoulet, M El Hajraoui, Andre Debenath
Richard G Roberts
Optically stimulated luminescence (OSL) measurements were made on individual, sand-sized grains of quartz from Middle Palaeolithic deposits at two cave sites (El Harhoura 2 and El Mnasra) on the Atlantic coast of Morocco. We were able to calculate OSL ages for 32 of the 33 samples collected from the Middle Palaeolithic deposits, including the earliest and latest Aterian levels at both sites. These ages reveal periods of occupation between about 110 and 95 ka (thousands of years ago), and at ~75 ka. A late Middle Palaeolithic occupation of El Harhoura 2 is also recorded at ~55 ka. Our single-grain OSL …
Single-Grain Optical Dating Of Grave-Infill Associated With Human Burials At Lake Mungo Australia, Jonathon Olley, Richard Roberts, Hiroyuki Yoshida, James M Bowler
Single-Grain Optical Dating Of Grave-Infill Associated With Human Burials At Lake Mungo Australia, Jonathon Olley, Richard Roberts, Hiroyuki Yoshida, James M Bowler
Richard G Roberts
Recent age constraints on Australia's oldest human remains (Mungo I and III), found at Lake Mungo in western New South Wales, relied on optical dating of sands from the same stratigraphic units as those into which the remains had been inserted (42±3 ka) and those that overlay the graves (38±2 ka), giving a burial age of 40±2 ka. This indirect means of dating the burials was necessary because the original site from which the remains had been excavated had been completely eroded away. At the time of the original excavation of the Mungo III grave, blocks of sediment from the …
New Ages For Human Occupation And Climatic Change At Lake Mungo Australia, James Bowler, Harvey Johnston, Jon M Olley, John Prescott, Richard Roberts, Wilfred Shawcross, Nigel Spooner
New Ages For Human Occupation And Climatic Change At Lake Mungo Australia, James Bowler, Harvey Johnston, Jon M Olley, John Prescott, Richard Roberts, Wilfred Shawcross, Nigel Spooner
Richard G Roberts
Australia’s oldest human remains, found at Lake Mungo, include the world’s oldest ritual ochre burial (Mungo III) and the first recorded cremation (Mungo I). Until now, the importance of these finds has been constrained by limited chronologies and palaeoenvironmental information. Mungo III, the source of the world’s oldest human mitochondrial DNA, has been variously estimated at 30 thousand years (kyr) old, 42–45 kyr old and 62 +/- 6 kyr old. while radiocarbon estimates placed theMungo I cremation near 20–26 kyr ago. Here we report a new series of 25 optical ages showing that both burials occurred at 40 +/- 2 …
Chronologies Of Carbon And Of Silica: Evidence Concerning The Dating Of The Earliest Human Presence In Northern Australia, Richard Roberts, Richard Jones
Chronologies Of Carbon And Of Silica: Evidence Concerning The Dating Of The Earliest Human Presence In Northern Australia, Richard Roberts, Richard Jones
Richard G Roberts
No abstract provided.
Human History Written In Stone And Blood, Zenobia Jacobs, Richard Roberts
Human History Written In Stone And Blood, Zenobia Jacobs, Richard Roberts
Richard G Roberts
Even by archaeological standards, Blombos Cave is a modestly sized shelter. Yet artifacts recovered from just 13 cubic meters of deposit inside transformed our understanding of when our species developed behavioral attributes we associate with “modern” humans. From this cramped hole in a sandstone cliff on the Southern Cape coast of South Africa, Christopher Henshilwood and his colleagues unearthed evidence of symbolic expression, in the form of abstract designs (carved ochre bars) and personal ornaments (shell beads) at least 70,000 years old. That is more than 35,000 years before anything comparable emerged in Europe.
The Celtic Chronologist: Rhys Jones And The Dating Of The Human Colonisation Of Australia, Richard Roberts
The Celtic Chronologist: Rhys Jones And The Dating Of The Human Colonisation Of Australia, Richard Roberts
Richard G Roberts
No abstract provided.
Early Human Occupation At Devil's Lair, South-Western Australia, Christian Turney, M Bird, L K Fifield, Richard Roberts, Michael Smith, C Dortch, R. Grun, E Lawson, Linda Ayliffe, G Miller, J Dortch, R Creswell
Early Human Occupation At Devil's Lair, South-Western Australia, Christian Turney, M Bird, L K Fifield, Richard Roberts, Michael Smith, C Dortch, R. Grun, E Lawson, Linda Ayliffe, G Miller, J Dortch, R Creswell
Richard G Roberts
No abstract provided.
Human Whole-Body Reaching In Normal Gravity And Microgravity Reveals A Strong Temporal Coordination Between Postural And Focal Task Components, Jerome Patron, Paul Stapley, Thierry Pozzo
Human Whole-Body Reaching In Normal Gravity And Microgravity Reveals A Strong Temporal Coordination Between Postural And Focal Task Components, Jerome Patron, Paul Stapley, Thierry Pozzo
Dr Paul J Stapley
Previous experiments by our group in normal gravity (1 G) have revealed spatial relationships between postural and focal components of whole-body reaching and pointing movements. We suggested that these relationships could be explained partly through the use of gravity to displace the CoM and attain the object or target position. In this study we compared human whole-body reaching in 1 G and microgravity (0 G) in order to more fully investigate how gravity contributes to strategies adopted for task execution and to determine possible invariant temporal relationships between multiple segments. Whole-body reaching movements made from the standing position in two …
Polysaccharopeptide Enhances The Anticancer Activity Of Doxorubicin And Etoposide On Human Breast Cancer Cells Zr-75-30, Jennifer Man-Fan Wan, Wai Hung Sit, Jimmy Chun Yu Louie
Polysaccharopeptide Enhances The Anticancer Activity Of Doxorubicin And Etoposide On Human Breast Cancer Cells Zr-75-30, Jennifer Man-Fan Wan, Wai Hung Sit, Jimmy Chun Yu Louie
Jimmy Chun Yu Louie
In search of natural bioactive microbial compounds with adjuvant properties, we have previously showed that the polysaccharopeptide (PSP), isolated from Chinese medicinal mushroom Coriolus versicolor, was able to enhance the cytotoxicity of certain S-phase targeted-drugs on human leukemic HL-60 cells via some cell-cycle and apoptotic-dependent pathways. The present study aimed to investigate whether the synergism of mechanisms of PSP with certain chemotherapeutic drugs also applies to human breast cancer. PSP treatment enhanced the cytotoxicity of doxorubicin (Doxo), etoposide (VP-16) but not cytarabine (Ara-C). Bivariate bromodeoxyuridine (BrdUrd)/DNA flow cytometry analysis estimated a longer DNA synthesis time (Ts) for the PSP treated …
Identification Of Phospholipids In Human Meibum By Nano-Electrospray Ionisation Tandem Mass Spectrometry, Jennifer T. Saville, Zhenjun Zhao, Mark Dp Willcox, Manjula A. Ariyavidana, Stephen J. Blanksby, Todd W. Mitchell
Identification Of Phospholipids In Human Meibum By Nano-Electrospray Ionisation Tandem Mass Spectrometry, Jennifer T. Saville, Zhenjun Zhao, Mark Dp Willcox, Manjula A. Ariyavidana, Stephen J. Blanksby, Todd W. Mitchell
Stephen Blanksby
Meibum is believed to be the major source of tear !lm lipids, which are vital in the prevention of excessevaporation of the aqueous phase. The complete lipid composition of meibum has yet to be established.While earlier studies reported the presence of phospholipids in human meibum, recent mass spectrometricstudies have not detected them. In this study we use electrospray ionisation tandem massspectrometry to investigate the presence of phospholipids in meibum and provide comparison to thephospholipid pro!le of tears.Lipids were extracted from human meibum and tear samples using standard biphasic methods andanalysed by nano-electrospray ionisation tandem mass spectrometry using targeted ion scans. …