Open Access. Powered by Scholars. Published by Universities.®
Social and Behavioral Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Social and Behavioral Sciences
Ubiquitous Molecular Substrates For Associative Learning And Activity-Dependent Neuronal Facilitation., Louis D. Matzel, Andrew C. Talk, Isabel A. Muzzio, Ronald F. Rogers
Ubiquitous Molecular Substrates For Associative Learning And Activity-Dependent Neuronal Facilitation., Louis D. Matzel, Andrew C. Talk, Isabel A. Muzzio, Ronald F. Rogers
Ronald F. Rogers
Recent evidence suggests that many of the molecular cascades and substrates that contribute to learning-related forms of neuronal plasticity may be conserved across ostensibly disparate model systems. Notably, the facilitation of neuronal excitability and synaptic transmission that contribute to associative learning in Aplysia and Hermissenda, as well as associative LTP in hippocampal CA1 cells, all require (or are enhanced by) the convergence of a transient elevation in intracellular Ca2+ with transmitter binding to metabotropic cell-surface receptors. This temporal convergence of Ca2+ and G-protein-stimulated second-messenger cascades synergistically stimulates several classes of serine/threonine protein kinases, which in turn modulate receptor function or …
Higher-Order Associative Processing In Hermissenda Suggests Multiple Sites Of Neuronal Modulation., Ronald F. Rogers, Louis D. Matzel
Higher-Order Associative Processing In Hermissenda Suggests Multiple Sites Of Neuronal Modulation., Ronald F. Rogers, Louis D. Matzel
Ronald F. Rogers
Two important features of modern accounts of associative learning are (1) the capacity for contextual stimuli to serve as a signal for an unconditioned stimulus (US) and (2) the capacity for a previously conditioned (excitatory) stimulus to "block" learning about a redundant stimulus when both stimuli serve as a signal for the same US. Here, we examined the process of blocking, thought by some to reflect a cognitive aspect of classical conditioning, and its underlying mechanisms in the marine mollusc Hermissenda. In two behavioral experiments, a context defined by chemosensory stimuli was made excitatory by presenting unsignalled USs (rotation) in …
Postsynaptic Ca2+, But Not Cumulative Depolarization, Is Necessary For The Induction Of Associative Plasticity In Hermissenda, Ronald F. Rogers, R. F. Matzel
Postsynaptic Ca2+, But Not Cumulative Depolarization, Is Necessary For The Induction Of Associative Plasticity In Hermissenda, Ronald F. Rogers, R. F. Matzel
Ronald F. Rogers
The neuronal modifications that underlie associative memory in Hermissenda have their origins in a synaptic interaction between the visual and vestibular systems, and can be mimicked by contiguous in vitro stimulation of these converging pathways. At the offset of vestibular stimulation (i.e., hair cell activity), the B photoreceptors are briefly released from synaptic inhibition resulting in a slight depolarization (2–4 mV). If contiguous pairings of light-induced depolarization and presynaptic vestibular activity occur in close temporal succession, this depolarization “accumulates” and has been hypothesized to culminate in a sustained rise in intracellular Ca2+ and a resultant Ca(2+)-mediated phosphorylation of K+ channels …