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Worldwide Distribution Of The Human Apolipoprotein E Gene - The Association Between Apoe, Subsistence, And Latitude, Tiffany S. Ho
Worldwide Distribution Of The Human Apolipoprotein E Gene - The Association Between Apoe, Subsistence, And Latitude, Tiffany S. Ho
Theses and Dissertations
The human apolipoprotein E gene (APOE) plays an important role in metabolizing lipids, regulating plasma cholesterol, and maintaining biological function. Structural differences in APOE variants impact cholesterol absorption and health risk, so that alleles serve as biomarkers for numerous cardiovascular and neurological diseases (Lai 2015). Variant differences are determined by changes in two single nucleotide polymorphisms (SNPs), rs429358 and rs7412. Distribution of alleles varies across populations. Allele frequencies in populations have been shown to be associated with cultural and environmental factors, including subsistence strategy and latitude (Eisenberg 2010).
This study aims to provide a cross-population, genetic association study …