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Nociception

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Full-Text Articles in Social and Behavioral Sciences

Can Physical Activity Modulate Pain Perception During Ontogenesis?, Maciej Pawlak, Aleksandra Jazdzewska, Katarzyna Leznicka Mar 2022

Can Physical Activity Modulate Pain Perception During Ontogenesis?, Maciej Pawlak, Aleksandra Jazdzewska, Katarzyna Leznicka

Baltic Journal of Health and Physical Activity

The aim of the paper is to emphasise the significance of physical activity as an element directly or indirectly modulating the perception of pain during ontogenesis. Pain is a distinctive sensory sensation and also a subjective criterion of health or disease. In contrast to other modalities (taste, smell, touch), it triggers solely negative emotions and sensations. Pain is a highly individualised sensory phenomenon, involving the physical, cognitive and emotional spheres of human life. Different reactions to pain during ontogeny most often result from the loss of communication skills, a systematic decrease in the functions of all systems and organs, in …

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Emotional Component Of Pain Perception In The Medicinal Leech?, Brian D. Burrell Jan 2022

Emotional Component Of Pain Perception In The Medicinal Leech?, Brian D. Burrell

Animal Sentience

Crump et al. have provided a series of criteria to assess animal sentience that is focused on the perception of pain, which is known to have both sensory and emotional components. They also provide a qualitative scoring system to assess data that address the eight criteria and apply this paradigm to decapod crustaceans. The criteria laid out have the potential to be applied to other invertebrates typically thought to have sensory response to tissue damage, but no emotional component to pain perception.

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A Framework For Evaluating Evidence Of Pain In Animals, Matilda Gibbons, Lars Chittka Jan 2022

A Framework For Evaluating Evidence Of Pain In Animals, Matilda Gibbons, Lars Chittka

Animal Sentience

Crump et al. define eight criteria indicating sentience in animals, with a focus on pain. Here, we point out the risk of false negative or false positive diagnoses of pain. Criteria of different levels of inclusivity are useful for using the precautionary principle in animal welfare considerations, and for more formal scientific evidence of pain. We suggest tightening the criteria -- from more general evidence of sentience to pain alone -- because crucial evidence for animal welfare decisions might otherwise be missed for animals subjected to invasive and injurious procedures.

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Inhibition Of Pain Or Response To Injury In Invertebrates And Vertebrates, Matilda Gibbons, Sajedeh Sarlak Jan 2020

Inhibition Of Pain Or Response To Injury In Invertebrates And Vertebrates, Matilda Gibbons, Sajedeh Sarlak

Animal Sentience

In certain situations, insects appear to lack a response to noxious stimuli that would cause pain in humans. For example, from the fact that male mantids continue to mate while being eaten by their partner it does not follow that insects do not feel pain; it could be the result of modulation of nociceptive inputs or behavioural outputs. When we try to infer the underlying mental state of an insect from its behaviour, it is important to consider the behavioural effects of the associated physiological and neurobiological mechanisms.

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Welfare Challenges Influence The Complexity Of Movement: Fractal Analysis Of Behaviour In Zebrafish, Anthony G. Deakin, Joseph W. Spencer, Andrew R. Cossins, Iain S. Young, Lynne U. Sneddon Oct 2019

Welfare Challenges Influence The Complexity Of Movement: Fractal Analysis Of Behaviour In Zebrafish, Anthony G. Deakin, Joseph W. Spencer, Andrew R. Cossins, Iain S. Young, Lynne U. Sneddon

Lynne Sneddon, PhD

The ability to assess welfare is an important refinement that will ensure the good condition of animals used in experimentation. The present study investigated the impact of invasive procedures on the patterns of movement of zebrafish (Danio rerio). Recordings were made before and after fin clipping, PIT tagging and a standard pain test and these were compared with control and sham handled zebrafish. The fractal dimension (FD) from the 3D trajectories was calculated to determine the effect of these treatments on the complexity of movement patterns. While the FD of zebrafish trajectories did not differ over time in either the …

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Reduction In Activity By Noxious Chemical Stimulation Is Ameliorated By Immersion In Analgesic Drugs In Zebrafish, Javier Lopez-Luna, Qussay Al-Jubouri, Waleed Al-Nuaimy, Lynne U. Sneddon Oct 2019

Reduction In Activity By Noxious Chemical Stimulation Is Ameliorated By Immersion In Analgesic Drugs In Zebrafish, Javier Lopez-Luna, Qussay Al-Jubouri, Waleed Al-Nuaimy, Lynne U. Sneddon

Lynne Sneddon, PhD

Research has recently demonstrated that larval zebrafish show similar molecular responses to nociception to those of adults. Our study explored whether unprotected larval zebrafish exhibited altered behaviour after exposure to noxious chemicals and screened a range of analgesic drugs to determine their efficacy to reduce these responses. This approach aimed to validate larval zebrafish as a reliable replacement for adults as well as providing a high-throughput means of analysing behavioural responses. Zebrafish at 5 days postfertilization were exposed to known noxious stimuli: acetic acid (0.01%, 0.1% and 0.25%) and citric acid (0.1%, 1% and 5%). The behavioural response of each …

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Philosophical Background Of Attitudes Toward And Treatment Of Invertebrates, Jennifer A. Mather Aug 2019

Philosophical Background Of Attitudes Toward And Treatment Of Invertebrates, Jennifer A. Mather

Jennifer Mather, PhD

People who interact with or make decisions about invertebrate animals have an attitude toward them, although they may not have consciously worked it out. Three philosophical approaches underlie this attitude. The fi rst is the contractarian, which basically contends that animals are only automata and that we humans need not concern ourselves with their welfare except for our own good, because cruelty and neglect demean us. A second approach is the utilitarian, which focuses on gains versus losses in interactions between animals, including humans. Given the sheer numbers of invertebrates—they constitute 99% of the animals on the planet—this attitude implicitly …

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Welfare Challenges Influence The Complexity Of Movement: Fractal Analysis Of Behaviour In Zebrafish, Anthony G. Deakin, Joseph W. Spencer, Andrew R. Cossins, Iain S. Young, Lynne U. Sneddon Feb 2019

Welfare Challenges Influence The Complexity Of Movement: Fractal Analysis Of Behaviour In Zebrafish, Anthony G. Deakin, Joseph W. Spencer, Andrew R. Cossins, Iain S. Young, Lynne U. Sneddon

Experimental Research and Animal Welfare Collection

The ability to assess welfare is an important refinement that will ensure the good condition of animals used in experimentation. The present study investigated the impact of invasive procedures on the patterns of movement of zebrafish (Danio rerio). Recordings were made before and after fin clipping, PIT tagging and a standard pain test and these were compared with control and sham handled zebrafish. The fractal dimension (FD) from the 3D trajectories was calculated to determine the effect of these treatments on the complexity of movement patterns. While the FD of zebrafish trajectories did not differ over time in either the …

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If It Looks Like A Duck: Fish Fit The Criteria For Pain Perception, Julia E. Meyers-Manor Jan 2018

If It Looks Like A Duck: Fish Fit The Criteria For Pain Perception, Julia E. Meyers-Manor

Animal Sentience

Whereas we have denied the experience of pain to animals, including human babies, the evidence is becoming clearer that animals across a variety of species have the capacity to feel pain (Bellieni, 2012). As converging findings are collected from pain studies and the study of cognition, it is becoming harder to deny that fish are among the species that do feel pain.

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Pain In Fish: Evidence From Peripheral Nociceptors To Pallial Processing, Michael L. Woodruff Jan 2018

Pain In Fish: Evidence From Peripheral Nociceptors To Pallial Processing, Michael L. Woodruff

Animal Sentience

The target article by Sneddon et al. (2018) presents convincing behavioral and pharmacological evidence that ray-finned fish consciously perceive noxious stimuli as painful. One objection to this interpretation of the evidence is that the fish nervous system is not complex enough to support the conscious experience of pain. Data that contradict this objection are presented in this commentary. The neuroanatomy and neurophysiology of the fish nervous system from the peripheral nerves to the pallium is able to support the sentient appreciation of pain.

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Denialism And Muddying The Water Or Organized Skepticism And Clarity? That Is The Question, Ben Diggles, Howard I. Browman Jan 2018

Denialism And Muddying The Water Or Organized Skepticism And Clarity? That Is The Question, Ben Diggles, Howard I. Browman

Animal Sentience

The research being commented on here has been criticized and defended in journals. Sneddon et al. (2018) add nothing substantive. We have nothing further to add. Readers are referred to Diggles (2018) and to Browman et al. (2018) for a detailed assessment.

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Defining Pain And Painful Sentience In Animals, Edgar T. Walters Jan 2018

Defining Pain And Painful Sentience In Animals, Edgar T. Walters

Animal Sentience

Sentience is essential to most definitions of pain, including a detailed definition invoked by Sneddon et al. to argue that adult and perhaps larval fish feel pain. Because proving painful sentience in non-human animals is not feasible, multiple lines of indirect evidence are needed to implicate pain. This commentary examines the list of 17 criteria used by Sneddon et al. to conclude that fish have conscious pain. The criteria include tests of nociceptive, motivational, and cognitive properties useful for revealing pain-like states that can be understood biologically and be related evolutionarily to human pain. However, additional research is needed to …

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Reduction In Activity By Noxious Chemical Stimulation Is Ameliorated By Immersion In Analgesic Drugs In Zebrafish, Javier Lopez-Luna, Qussay Al-Jubouri, Waleed Al-Nuaimy, Lynne U. Sneddon Apr 2017

Reduction In Activity By Noxious Chemical Stimulation Is Ameliorated By Immersion In Analgesic Drugs In Zebrafish, Javier Lopez-Luna, Qussay Al-Jubouri, Waleed Al-Nuaimy, Lynne U. Sneddon

Anesthesia and Analgesia Collection

Research has recently demonstrated that larval zebrafish show similar molecular responses to nociception to those of adults. Our study explored whether unprotected larval zebrafish exhibited altered behaviour after exposure to noxious chemicals and screened a range of analgesic drugs to determine their efficacy to reduce these responses. This approach aimed to validate larval zebrafish as a reliable replacement for adults as well as providing a high-throughput means of analysing behavioural responses. Zebrafish at 5 days postfertilization were exposed to known noxious stimuli: acetic acid (0.01%, 0.1% and 0.25%) and citric acid (0.1%, 1% and 5%). The behavioural response of each …

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The Potential For Sentience In Fishes, Jay R. Stauffer Jr. Jan 2017

The Potential For Sentience In Fishes, Jay R. Stauffer Jr.

Animal Sentience

Balcombe’s book is filled with information on the biology, behavior, and life history of fishes. I do not agree with all his premises. I am still somewhat perplexed about the discussion of whether fish feel pain; I am not sure whether the distinction between nociception and pain makes any difference. Overall, however, his treatment of the principles of both natural and sexual selection is comprehensive and accurate, and has greatly increased my knowledge and awareness of the biology, ethology, and potential for sentience in fishes. In summary, this work has exposed me to new ideas about how to examine fishes …

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Addressing Distress And Pain In Animal Research: The Veterinary, Research, Societal, Regulatory And Ethical Contexts For Moving Forward, Kathleen Conlee, Martin Stephens, Andrew N. Rowan Jul 2016

Addressing Distress And Pain In Animal Research: The Veterinary, Research, Societal, Regulatory And Ethical Contexts For Moving Forward, Kathleen Conlee, Martin Stephens, Andrew N. Rowan

Martin Stephens, PhD

While most people recognize that biomedical scientists are searching for knowledge that will improve the health of humans and animals, the image of someone deliberately causing harm to an animal in order to produce data that may lead to some future benefit has always prompted an uncomfortable reaction outside the laboratory. However, proponents of animal research have usually justified the practice by reference to greater benefits (new knowledge and medical treatments) over lesser costs (in animal suffering and death). Given that one of the costs of animal research is the suffering experienced by the animals, the goal of eliminating distress …

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Fish Pain: An Inconvenient Truth, Culum Brown May 2016

Fish Pain: An Inconvenient Truth, Culum Brown

Culum Brown, PhD

Whether fish feel pain is a hot political topic. The consequences of our denial are huge given the billions of fish that are slaughtered annually for human consumption. The economic costs of changing our commercial fishery harvest practices are also likely to be great. Key outlines a structure-function analogy of pain in humans, tries to force that template on the rest of the vertebrate kingdom, and fails. His target article has so far elicited 34 commentaries from scientific experts from a broad range of disciplines; only three of these support his position. The broad consensus from the scientific community is …

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Fish Pain: An Inconvenient Truth, Culum Brown Jan 2016

Fish Pain: An Inconvenient Truth, Culum Brown

Animal Sentience

Whether fish feel pain is a hot political topic. The consequences of our denial are huge given the billions of fish that are slaughtered annually for human consumption. The economic costs of changing our commercial fishery harvest practices are also likely to be great. Key outlines a structure-function analogy of pain in humans, tries to force that template on the rest of the vertebrate kingdom, and fails. His target article has so far elicited 34 commentaries from scientific experts from a broad range of disciplines; only three of these support his position. The broad consensus from the scientific community is …

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Fish Lack The Brains And The Psychology For Pain, Stuart W.G. Derbyshire Jan 2016

Fish Lack The Brains And The Psychology For Pain, Stuart W.G. Derbyshire

Animal Sentience

Debate about the possibility of fish pain focuses largely on the fish’s lack of the cortex considered necessary for generating pain. That view is appealing because it avoids relatively abstract debate about the nature of pain experience and subjectivity. Unfortunately, however, that debate cannot be entirely avoided. Subcortical circuits in the fish might support an immediate, raw, “pain” experience. The necessity of the cortex only becomes obvious when considering pain as an explicitly felt subjective experience. Attributing pain to fish only seems absurd when pain is considered as a state of explicit knowing.

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Pain And Fish Welfare, Eliane Gonçalves-De-Freitas Jan 2016

Pain And Fish Welfare, Eliane Gonçalves-De-Freitas

Animal Sentience

The evolutionary approach of Key’s (2016) target article, generically comparing humans with fish of all kinds, is simplistic. The author ignores published research on structural and molecular aspects of pain in fish. The target article reads more like a selective polemic against fish welfare than an even-handed analysis.

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Investigation Of Van Gogh-Like 2 Mrna Regulation And Localisation In Response To Nociception In The Brain Of Adult Common Carp (Cyprinus Carpio), Siobhan C. Reilly, Anja Kipar, David J. Hughes, John P. Quinn, Andrew R. Cossins, Lynne U. Sneddon Aug 2015

Investigation Of Van Gogh-Like 2 Mrna Regulation And Localisation In Response To Nociception In The Brain Of Adult Common Carp (Cyprinus Carpio), Siobhan C. Reilly, Anja Kipar, David J. Hughes, John P. Quinn, Andrew R. Cossins, Lynne U. Sneddon

Lynne Sneddon, PhD

The Van Gogh-like 2 (vangl2) gene is typically associated with planar cell polarity pathways, which is essential for correct orientation of epithelial cells during development. The encoded protein of this gene is a transmembrane protein and is highly conserved through evolution. Van Gogh-like 2 was selected for further study on the basis of consistent regulation after a nociceptive stimulus in adult common carp and rainbow trout in a microarray study. An in situ hybridisation was conducted in the brain of mature common carp (Cyprinus carpio), 1.5 and 3 h after a nociceptive stimulus comprising of an acetic acid injection to …

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Characterisation Of Chemosensory Trigeminal Receptors In The Rainbow Trout, Oncorhynchus Mykiss: Responses To Chemical Irritants And Carbon Dioxide, Jessica J. Mettam, Catherine R. Mccrohan, Lynne U. Sneddon Jul 2015

Characterisation Of Chemosensory Trigeminal Receptors In The Rainbow Trout, Oncorhynchus Mykiss: Responses To Chemical Irritants And Carbon Dioxide, Jessica J. Mettam, Catherine R. Mccrohan, Lynne U. Sneddon

Lynne Sneddon, PhD

Trigeminally innervated, mechanically sensitive chemoreceptors (M) were previously identified in rainbow trout, Oncorhynchus mykiss, but it is not known whether these receptors are responsive only to noxious, chemical irritants or have a general chemosensory function. This study aimed to characterise the stimulus–response properties of these receptors in comparison with polymodal nociceptors (P). Both P and M gave similar response profiles to acetic acid concentrations. The electrophysiological properties were similar between the two different afferent types. To determine whether the receptors have a nociceptive function, a range of chemical stimulants was applied to these receptors, including non-noxious stimuli such as ammonium …

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The Efficacy Of Three Types Of Analgesic Drugs In Reducing Pain In The Rainbow Trout, Oncorhynchus Mykiss, Jessica J. Mettam, Lois J. Oulton, Catherine R. Mccrohan, Lynne U. Sneddon Jul 2015

The Efficacy Of Three Types Of Analgesic Drugs In Reducing Pain In The Rainbow Trout, Oncorhynchus Mykiss, Jessica J. Mettam, Lois J. Oulton, Catherine R. Mccrohan, Lynne U. Sneddon

Lynne Sneddon, PhD

Recent research has shown the possibility of pain perception in fish; therefore, the use of analgesia or “painkillers” should be considered for invasive procedures. However, there is relatively little information on the effectiveness of analgesic drugs nor on the appropriate dose for fish. This study assessed the efficacy of three types of drug: an opioid, buprenorphine, a non-steroidal anti-inflammatory drug (NSAID), carprofen and a local anaesthetic, lidocaine. Each drug was tested at three doses on rainbow trout that were noxiously stimulated and the most effective dose was also given to fish experiencing no pain to investigate side-effects. Ventilation rate and …

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Defining And Assessing Animal Pain, Lynne U. Sneddon, Robert W. Elwood, Shelley A. Adamo, Matthew C. Leach Jun 2015

Defining And Assessing Animal Pain, Lynne U. Sneddon, Robert W. Elwood, Shelley A. Adamo, Matthew C. Leach

Lynne Sneddon, PhD

The detection and assessment of pain in animals is crucial to improving their welfare in a variety of contexts in which humans are ethically or legally bound to do so. Thus clear standards to judge whether pain is likely to occur in any animal species is vital to inform whether to alleviate pain or to drive the refinement of procedures to reduce invasiveness, thereby minimizing pain. We define two key concepts that can be used to evaluate the potential for pain in both invertebrate and vertebrate taxa. First, responses to noxious, potentially painful events should affect neurobiology, physiology and behaviour …

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Addressing Distress And Pain In Animal Research: The Veterinary, Research, Societal, Regulatory And Ethical Contexts For Moving Forward, Kathleen Conlee, Martin Stephens, Andrew N. Rowan Mar 2015

Addressing Distress And Pain In Animal Research: The Veterinary, Research, Societal, Regulatory And Ethical Contexts For Moving Forward, Kathleen Conlee, Martin Stephens, Andrew N. Rowan

Andrew N. Rowan, DPhil

While most people recognize that biomedical scientists are searching for knowledge that will improve the health of humans and animals, the image of someone deliberately causing harm to an animal in order to produce data that may lead to some future benefit has always prompted an uncomfortable reaction outside the laboratory. However, proponents of animal research have usually justified the practice by reference to greater benefits (new knowledge and medical treatments) over lesser costs (in animal suffering and death). Given that one of the costs of animal research is the suffering experienced by the animals, the goal of eliminating distress …

Go to article

Defining And Assessing Animal Pain, Lynne U. Sneddon, Robert W. Elwood, Shelley A. Adamo, Matthew C. Leach Nov 2014

Defining And Assessing Animal Pain, Lynne U. Sneddon, Robert W. Elwood, Shelley A. Adamo, Matthew C. Leach

Experimentation Collection

The detection and assessment of pain in animals is crucial to improving their welfare in a variety of contexts in which humans are ethically or legally bound to do so. Thus clear standards to judge whether pain is likely to occur in any animal species is vital to inform whether to alleviate pain or to drive the refinement of procedures to reduce invasiveness, thereby minimizing pain. We define two key concepts that can be used to evaluate the potential for pain in both invertebrate and vertebrate taxa. First, responses to noxious, potentially painful events should affect neurobiology, physiology and behaviour …

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Toward A Novel Model Of Pain In Zebrafish: Exposure To Water Containing Dilute Concentrations Of Acetic Acid, Amanda D. Currie May 2014

Toward A Novel Model Of Pain In Zebrafish: Exposure To Water Containing Dilute Concentrations Of Acetic Acid, Amanda D. Currie

Psychology Honors Projects

Existing models of pain in zebrafish (Danio rerio) require injection of acetic acid into localized areas including the lips. We are currently developing an alternative assay of pain in zebrafish that involves immersion in dilute concentrations of acetic acid. This assay involves placing subjects in a 120 mL beaker containing 100 mL of water taken from the subject’s original tank. After a 20-minute acclimation period, the experimental substances are added, if applicable. Subjects are exposed to the experimental substances for 30 minutes (unless otherwise specified), after which they are returned to their original tanks. A series of studies …

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Characterisation Of Chemosensory Trigeminal Receptors In The Rainbow Trout, Oncorhynchus Mykiss: Responses To Chemical Irritants And Carbon Dioxide, Jessica J. Mettam, Catherine R. Mccrohan, Lynne U. Sneddon Jan 2012

Characterisation Of Chemosensory Trigeminal Receptors In The Rainbow Trout, Oncorhynchus Mykiss: Responses To Chemical Irritants And Carbon Dioxide, Jessica J. Mettam, Catherine R. Mccrohan, Lynne U. Sneddon

Veterinary Science and Medicine Collection

Trigeminally innervated, mechanically sensitive chemoreceptors (M) were previously identified in rainbow trout, Oncorhynchus mykiss, but it is not known whether these receptors are responsive only to noxious, chemical irritants or have a general chemosensory function. This study aimed to characterise the stimulus–response properties of these receptors in comparison with polymodal nociceptors (P). Both P and M gave similar response profiles to acetic acid concentrations. The electrophysiological properties were similar between the two different afferent types. To determine whether the receptors have a nociceptive function, a range of chemical stimulants was applied to these receptors, including non-noxious stimuli such as ammonium …

Go to article

The Efficacy Of Three Types Of Analgesic Drugs In Reducing Pain In The Rainbow Trout, Oncorhynchus Mykiss, Jessica J. Mettam, Lois J. Oulton, Catherine R. Mccrohan, Lynne U. Sneddon Sep 2011

The Efficacy Of Three Types Of Analgesic Drugs In Reducing Pain In The Rainbow Trout, Oncorhynchus Mykiss, Jessica J. Mettam, Lois J. Oulton, Catherine R. Mccrohan, Lynne U. Sneddon

Veterinary Science and Medicine Collection

Recent research has shown the possibility of pain perception in fish; therefore, the use of analgesia or “painkillers” should be considered for invasive procedures. However, there is relatively little information on the effectiveness of analgesic drugs nor on the appropriate dose for fish. This study assessed the efficacy of three types of drug: an opioid, buprenorphine, a non-steroidal anti-inflammatory drug (NSAID), carprofen and a local anaesthetic, lidocaine. Each drug was tested at three doses on rainbow trout that were noxiously stimulated and the most effective dose was also given to fish experiencing no pain to investigate side-effects. Ventilation rate and …

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Philosophical Background Of Attitudes Toward And Treatment Of Invertebrates, Jennifer A. Mather Jan 2011

Philosophical Background Of Attitudes Toward And Treatment Of Invertebrates, Jennifer A. Mather

Societal Attitudes Toward Animals Collection

People who interact with or make decisions about invertebrate animals have an attitude toward them, although they may not have consciously worked it out. Three philosophical approaches underlie this attitude. The fi rst is the contractarian, which basically contends that animals are only automata and that we humans need not concern ourselves with their welfare except for our own good, because cruelty and neglect demean us. A second approach is the utilitarian, which focuses on gains versus losses in interactions between animals, including humans. Given the sheer numbers of invertebrates—they constitute 99% of the animals on the planet—this attitude implicitly …

Go to article

Investigation Of Van Gogh-Like 2 Mrna Regulation And Localisation In Response To Nociception In The Brain Of Adult Common Carp (Cyprinus Carpio), Siobhan C. Reilly, Anja Kipar, David J. Hughes, John P. Quinn, Andrew R. Cossins, Lynne U. Sneddon Nov 2009

Investigation Of Van Gogh-Like 2 Mrna Regulation And Localisation In Response To Nociception In The Brain Of Adult Common Carp (Cyprinus Carpio), Siobhan C. Reilly, Anja Kipar, David J. Hughes, John P. Quinn, Andrew R. Cossins, Lynne U. Sneddon

Veterinary Science and Medicine Collection

The Van Gogh-like 2 (vangl2) gene is typically associated with planar cell polarity pathways, which is essential for correct orientation of epithelial cells during development. The encoded protein of this gene is a transmembrane protein and is highly conserved through evolution. Van Gogh-like 2 was selected for further study on the basis of consistent regulation after a nociceptive stimulus in adult common carp and rainbow trout in a microarray study. An in situ hybridisation was conducted in the brain of mature common carp (Cyprinus carpio), 1.5 and 3 h after a nociceptive stimulus comprising of an acetic acid injection to …

Go to article

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