Social and Behavioral Sciences Commons^™

The Semantic Memory Imaging In Late Life Pilot Study, Michael Adam Sugarman

Wayne State University Dissertations

Introduction: Several functional magnetic resonance imaging (fMRI) studies have analyzed the famous name discrimination task (FNDT), an uncontrolled semantic memory probe requiring discrimination between famous and unfamiliar individuals. Completion of this simple task recruits a semantic memory network that has shown utility in determining risk for Alzheimer's disease (AD). Specific semantic memory probes using biographical information associated with famous individuals may build on previous findings and yield superior information regarding risk for AD.

Method: Sixteen cognitively intact elders completed the FNDT and two novel tasks during fMRI: Categories (matching famous individuals to occupational categories) and Attributes (matching famous individuals to …

Assessment Of The Semantic Knowledge Network In Older Adults With Familial History Of Alzheimer's Disease, Erin Marie Holcomb

Wayne State University Dissertations

Current techniques for the treatment of Alzheimer's disease rely on early implementation, which necessitates the need for accurate and early identification of individuals most at risk for future cognitive decline. Research has demonstrated the usefulness of examining the temporal gradient for long-term semantic knowledge in identification of such individuals. The assessment of the temporal gradient within varying levels of knowledge specificity, however, has received considerably less attention. In this study, we aimed to contrast accuracy and reaction times for semantic memory tasks tapping multiple dimensions of semantic specificity from multiple time epochs in adult children with and without a parental …