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Articles 1 - 4 of 4
Full-Text Articles in Social and Behavioral Sciences
Extracellular Chaperones Modulate The Effects Of Alzheimer's Patient Cerebrospinal Fluid On A Beta(1-42) Toxicity And Uptake , Justin J. Yerbury, Mark R. Wilson
Extracellular Chaperones Modulate The Effects Of Alzheimer's Patient Cerebrospinal Fluid On A Beta(1-42) Toxicity And Uptake , Justin J. Yerbury, Mark R. Wilson
Faculty of Science - Papers (Archive)
Alzheimer's disease is characterised by the inappropriate death of brain cells and accumulation of the A beta peptide in the brain. Thus, it is possible that there are fundamental differences between Alzheimer's disease patients and healthy individuals in their abilities to clear A beta from brain fluid and to protect neurons from A beta toxicity. In the present study, we examined (1) the cytotoxicity of Alzheimer's disease cerebrospinal fluid (CSF) compared to control CSF, (2) the ability of Alzheimer's disease and control CSF to protect cells from A beta toxicity and to promote cell-mediated clearance of A beta and lastly …
Differential Endocytosis Of Tissue Plasminogen Activator By Serpins Pai-1 And Pai-2 On Human Peripheral Blood Monocytes, Jodi A. Lee, David Croucher, Marie Ranson
Differential Endocytosis Of Tissue Plasminogen Activator By Serpins Pai-1 And Pai-2 On Human Peripheral Blood Monocytes, Jodi A. Lee, David Croucher, Marie Ranson
Faculty of Science - Papers (Archive)
Generation of the broad spectrum protease plasmin is facilitated by the tissue (t-PA) and urokinase (u-PA) plasminogen activators, within multiple physiological and disease states. Finely tuned control of this proteolytic cascade is exerted by the plasminogen activator inhibitors type-1 (PAI-1/SERPINE1) and 2 (PAI-2/SERPINB2). Expression of this network of activators and inhibitors by cells of myeloid lineage appears to be highly interchangeable between physiological environments, and whilst the role of PAI-1 and PAI-2 in regulating u-PA-dependent functions is well established, the interaction between t-PA and PAI-2 on these cell types is poorly characterised. To this end, we used freshly isolated peripheral …
Reaction Of The C2h Radical With 1-Butyne (C4h6): Low Temperature Kinetics And Isomer-Specific Product Detection, Satchin Soorkia, Adam J. Trevitt, Talitha M. Selby, David L. Osborn, Craig A. Taatjes, Kevin R. Wilson, Stephen R. Leone
Reaction Of The C2h Radical With 1-Butyne (C4h6): Low Temperature Kinetics And Isomer-Specific Product Detection, Satchin Soorkia, Adam J. Trevitt, Talitha M. Selby, David L. Osborn, Craig A. Taatjes, Kevin R. Wilson, Stephen R. Leone
Faculty of Science - Papers (Archive)
No abstract provided.
Distribution Of Class 1 Integrons With Is26-Mediated Deletions In Their 3'-Conserved Segments In Escherichia Coli Of Human And Animal Origin., Fay E. Dawes, Alexander Kuzevski, Karl A Bettelheim, Michael A Hornitzky, Steven P Djordjevic, Mark J. Walker
Distribution Of Class 1 Integrons With Is26-Mediated Deletions In Their 3'-Conserved Segments In Escherichia Coli Of Human And Animal Origin., Fay E. Dawes, Alexander Kuzevski, Karl A Bettelheim, Michael A Hornitzky, Steven P Djordjevic, Mark J. Walker
Faculty of Science - Papers (Archive)
Class 1 integrons play a role in the emergence of multi-resistant bacteria by facilitating the recruitment of gene cassettes encoding antibiotic resistance genes. 512 E. coli strains sourced from humans (n = 202), animals (n = 304) and the environment (n = 6) were screened for the presence of the intI1 gene. In 31/79 integron positive E. coli strains, the gene cassette regions could not be PCR amplified using standard primers. DNA sequence analysis of 6 serologically diverse strains revealed atypical integrons harboured the dfrA5 cassette gene and only 24 bp of the integron 3'-conserved segment (CS) remained, due to …