Social and Behavioral Sciences Commons^™

Functional Magnetic Resonance Imaging Of Semantic Memory As A Presymptomatic Biomarker Of Alzheimer’S Disease Risk, Michael Sugarman, John L. Woodard, Kristy A. Nielson, Michael Seidenberg, J. Carson Smith, Sally Durgerian, Stephen M. Rao

Kristy Nielson

Extensive research efforts have been directed toward strategies for predicting risk of developing Alzheimer's disease (AD) prior to the appearance of observable symptoms. Existing approaches for early detection of AD vary in terms of their efficacy, invasiveness, and ease of implementation. Several non-invasive magnetic resonance imaging strategies have been developed for predicting decline in cognitively healthy older adults. This review will survey a number of studies, beginning with the development of a famous name discrimination task used to identify neural regions that participate in semantic memory retrieval and to test predictions of several key theories of the role of the …