Open Access. Powered by Scholars. Published by Universities.®
Social and Behavioral Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Social and Behavioral Sciences
Comparison Of Semantic And Episodic Memory Bold Fmri Activation In Predicting Cognitive Decline In Older Adults, Nathan Hantke, Kristy A. Nielson, John L. Woodard, Leslie M. Guidotti Breting, Alissa Butts, Michael Seidenberg, J. Carson Smith, Sally Durgerian, Melissa A. Lancaster, Monica Matthews, Michael Sugarman, Stephen M. Rao
Comparison Of Semantic And Episodic Memory Bold Fmri Activation In Predicting Cognitive Decline In Older Adults, Nathan Hantke, Kristy A. Nielson, John L. Woodard, Leslie M. Guidotti Breting, Alissa Butts, Michael Seidenberg, J. Carson Smith, Sally Durgerian, Melissa A. Lancaster, Monica Matthews, Michael Sugarman, Stephen M. Rao
Kristy Nielson
Previous studies suggest that task-activated functional magnetic resonance imaging (fMRI) can predict future cognitive decline among healthy older adults. The present fMRI study examined the relative sensitivity of semantic memory (SM) versus episodic memory (EM) activation tasks for predicting cognitive decline. Seventy-eight cognitively intact elders underwent neuropsychological testing at entry and after an 18-month interval, with participants classified as cognitively “Stable” or “Declining” based on ≥1.0 SD decline in performance. Baseline fMRI scanning involved SM (famous name discrimination) and EM (name recognition) tasks. SM and EM fMRI activation, along with Apolipoprotein E (APOE) ε4 status, served as predictors of cognitive …