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Full-Text Articles in Social and Behavioral Sciences
Measuring Depression In Prostate Cancer Patients: Does The Scale Used Make A Difference?, Christopher Sharpley, Vicki Bitsika, David Christie, Myra Hunter
Measuring Depression In Prostate Cancer Patients: Does The Scale Used Make A Difference?, Christopher Sharpley, Vicki Bitsika, David Christie, Myra Hunter
Vicki Bitsika
This study investigated differences in the scores, relative severity and major depressive disorder (MDD) and subsyndromal depression status from three standardised self-report scales for depression in prostate cancer (PCa) patients. The Hospital Anxiety and Depression Scale Depression subscale (HADS-D), the Self-rating Depression Scale (SDS) and the Patient Health Questionnaire (PHQ-9) for depression were administered to a sample of 138 PCa patients via mail-out self-reports in Queensland, Australia during May 2014. Despite significant correlations between the total scores from the three scales, severity classification differed across the three scales and there was evidence of considerable underestimation of depression by the HADS-D …
Predictors Of Depression In Prostate Cancer Patients: A Comparison Of Psychological Resilience Versus Pre-Existing Anxiety And Depression, Christopher Sharpley, Vicki Bitsika, Addie Wootten, David Christie
Predictors Of Depression In Prostate Cancer Patients: A Comparison Of Psychological Resilience Versus Pre-Existing Anxiety And Depression, Christopher Sharpley, Vicki Bitsika, Addie Wootten, David Christie
Vicki Bitsika
Background: Previous anxiety and depression can influence current anxiety and depression, and psychological resilience may be a buffer against current anxiety and depression. However, despite the relevance of these two sets of predictors of anxiety and depression, and their potential in treatment planning, no reports have been published on their role in post-diagnosis anxiety and depression among prostate cancer (PCa) patients. Therefore, this study aimed to determine the roles of these predictors in a sample of men with prostate cancer. Method: Retrospective self-reports of anxiety and depression for how they were before receiving their diagnosis of PCa and at the …
Acceptance And Commitment Therapy (Act) For Improving The Lives Of Cancer Patients: A Preliminary Study, Danielle Feros, Lisbeth Lane, Joseph Ciarrochi, John Blackledge
Acceptance And Commitment Therapy (Act) For Improving The Lives Of Cancer Patients: A Preliminary Study, Danielle Feros, Lisbeth Lane, Joseph Ciarrochi, John Blackledge
joseph Ciarrochi
Background This preliminary study examined the effectiveness of an Acceptance and Commitment Therapy (ACT) intervention at improving the quality of life among cancer patients. It was hypothesised that over the course of the intervention, patients would report increased psychological flexibility through acceptance of unpleasant thoughts and feelings, and that increased psychological flexibility would lead to improvements in distress, mood, and quality of life. Method Forty-five cancer patients participated in an ACT intervention. Outcome measures included self-reported distress, mood disturbance, psychological flexibility, and quality of life. Data were collected at pre, mid, and post-intervention and at 3-month follow-up. Results The data …
The Link Between Value Motives, Value Success, And Well-Being Among People Diagnosed With Cancer, Lisbeth Lane, Joseph Ciarrochi, Danielle Fisher
The Link Between Value Motives, Value Success, And Well-Being Among People Diagnosed With Cancer, Lisbeth Lane, Joseph Ciarrochi, Danielle Fisher
joseph Ciarrochi
Objective: This study investigated the relationship between cancer patientÿs values and cancerrelated distress.Method: A total of 107 patients with cancer diagnoses completed an anonymousquestionnaire.Results: Less self-regulating motivation for health values was significantly related to poorerwell-being. Greater success at living oneÿs values was significantly related to improved wellbeingand distress-related outcomes. Sex difference analysis suggested that success atfriendship values was linked to less cancer-related distress among women, but not men, whereassuccess at romantic relationship values was linked to less distress among men, but not women.Conclusion: The results have important implications for values focused interventions,highlighting the importance of facilitating success at valued living …
The Psychological Impact Of Anal Cancer Screening On Hiv-Infected Men, Jodie Landstra, Joseph Ciarrochi, Frank Deane, Leon Botes, Richard Hillman
The Psychological Impact Of Anal Cancer Screening On Hiv-Infected Men, Jodie Landstra, Joseph Ciarrochi, Frank Deane, Leon Botes, Richard Hillman
joseph Ciarrochi
Background Anal cancer rates are increasing in HIV-infected men. Screening programmes similar to prostate and cervical cancer have been recommended to reduce morbidity and mortality. Research shows that screening processes have psychological consequences that need to be considered. Limited investigation of the psychological impact of anal cancer screening has been conducted. Methods A prospective longitudinal survey of 291 men was conducted at three time points over 14 weeks at a public HIV clinic in Sydney, Australia. Self-report questionnaires measuring worry, distress, depression, anxiety, stress and health-related quality of life (SF-12) were collected. Results Those who had a biopsy recommended were …
Psychological Consequences Of Cancer Screening In Hiv, Jodie Landstra, Frank Deane, Joseph Ciarrochi
Psychological Consequences Of Cancer Screening In Hiv, Jodie Landstra, Frank Deane, Joseph Ciarrochi
joseph Ciarrochi
Purpose of review: There is a growing awareness of the increase in non-AIDS-defining cancers (NADC) in the HIV-infected population. Cancer screening is one means of reducing morbidity and mortality, but such screening may have psychological consequences across those with high and low-risk results, such as increased anxiety, worry and potential behavior change like increased self-examination or medical follow-up. This review examines the literature on psychological consequences of screening for NADC in HIV-infected populations. Recent findings: Anal cancer is the only cancer type in which the psychological consequence of screening has been investigated in HIV-infected populations. Screening increases worry about anal …
Does Resilience 'Buffer' Against Depression In Prostate Cancer Patients? A Multi-Site Replication Study, Christopher Sharpley, Vicki Bitsika, Addie Wootten, David Christie
Does Resilience 'Buffer' Against Depression In Prostate Cancer Patients? A Multi-Site Replication Study, Christopher Sharpley, Vicki Bitsika, Addie Wootten, David Christie
Vicki Bitsika
Although psychological resilience has been shown to 'buffer' against depression following major stressors, no studies have reported on this relationship within the prostate cancer (PCa) population, many of whom are at elevated risk of depression, health problems and suicide. To investigate the effects of resilience upon anxiety and depression in the PCa population, postal surveys of 425 PCa patients were collected from two sites: 189 PCa patients at site 1 and 236 at site 2. Background data plus responses to depression and resilience scales were collected. Results indicated that total resilience score was a significant buffer against depression across both …
Targeting Urokinase And The Transferrin Receptor With Novel, Anti-Mitotic N-Alkylisatin Cytotoxin Conjugates Causes Selective Cancer Cell Death And Reduces Tumor Growth, K Vine, V. Indira Chandran, J Locke, L Matesic, J Lee, D Skropeta, J Bremner, M Ranson
Targeting Urokinase And The Transferrin Receptor With Novel, Anti-Mitotic N-Alkylisatin Cytotoxin Conjugates Causes Selective Cancer Cell Death And Reduces Tumor Growth, K Vine, V. Indira Chandran, J Locke, L Matesic, J Lee, D Skropeta, J Bremner, M Ranson
Danielle Skropeta
Tumor-specific delivery of ligand-directed prodrugs can increase the therapeutic window of chemotherapeutics by maintaining efficacy whilst decreasing toxic side effects. We have previously described a series of synthetic N-alkylated isatin cytotoxins that destabilize microtubules and induce apoptosis with 10-fold greater potency than conventional anti-mitotics in vitro. Here, we report the characterization, in vitro cytotoxicity and in vivo efficacy of a lead compound, 5,7-dibromo-N-(p-hydroxymethylbenzyl)isatin (N-AI) conjugated via an esterase-labile linker (N-AIE) to two proven targeting ligands, transferrin (Tf) and plasminogen activator inhibitor type 2 (PAI-2/serpinB2). N-AI was released from N-AIE and the targeting ligands Tf/PAI-2 in an esterase-dependent manner at 37 …
Anti-Cancer Activity Of An Acid-Labile N-Alkylisatin Conjugate Targeting The Transferrin Receptor, Vineesh Indira Chandran, Lidia Matesic, Julie Locke, Danielle Skropeta, Marie Ranson, Kara Vine
Anti-Cancer Activity Of An Acid-Labile N-Alkylisatin Conjugate Targeting The Transferrin Receptor, Vineesh Indira Chandran, Lidia Matesic, Julie Locke, Danielle Skropeta, Marie Ranson, Kara Vine
Danielle Skropeta
We have previously reported a series of pH-sensitive imine-linked N-alkylisatin prodrugs that are stable at pH 7.4, but readily cleaved at pH 4.5. Herein, one of the most potent prodrugs, 5,7-dibromo-N-(pmethoxybenzyl) isatin (NAI), was functionalized with a para-phenylpropionic acid linker, and the resulting NAI–imine prodrug conjugated to transferrin (Tf) to form a NAI–imine–Tf conjugate. Cytotoxicity assays revealed the conjugate was equipotent to the free drug against MCF-7 breast cancer cells, with clear selectivity patterns based on TfR levels. These results suggest that this novel isatin-based cytotoxin conjugated to a tumor targeting protein via an acid-labile linker warrants further preclinical testing.
Do Patient-Reported Androgen-Deprivation Therapy Side Effects Predict Anxiety And Depression Among Prostate Cancer Patients Undergoing Radiotherapy? Implications For Psychosocial Therapy Interventions, Christopher Sharpley, Vicki Bitsika, David Christie
Do Patient-Reported Androgen-Deprivation Therapy Side Effects Predict Anxiety And Depression Among Prostate Cancer Patients Undergoing Radiotherapy? Implications For Psychosocial Therapy Interventions, Christopher Sharpley, Vicki Bitsika, David Christie
Vicki Bitsika
Antiandrogen therapy (AAT) is a common adjunct treatment for prostate cancer (PCa) patients and has shown significant benefits to long-term outcomes from radiation or surgery. Although AAT has some adverse side effects and data from breast cancer patients indicate that such side effects from hormonal therapies may contribute to anxiety and depression and may also hinder AAT treatment compliance, this issue has not been investigated within a sample of PCa patients. This study explores the incidence of AAT side effects in a sample of PCa patients, the links between those side effects and anxiety and depression, the possible ways in …
How Prostate Cancer Patients Cope: Evaluation And Refinement Of The Prostate Cancer Patients' Coping Strategies Questionnaire, Christopher Sharpley, Vicki Bitsika, David Christie
How Prostate Cancer Patients Cope: Evaluation And Refinement Of The Prostate Cancer Patients' Coping Strategies Questionnaire, Christopher Sharpley, Vicki Bitsika, David Christie
Vicki Bitsika
Background: Prostate cancer (PCa) patients suffer from identifiable stressors that may cause them anxiety and/or depression. In a previous study, an initial exploration of the ways in which PCa patients seek to cope with those stressors was described. However, several methodological limitations prevented direct comparisons of the relative effectiveness of patients’ coping strategies. To further investigate this issue, a standardised format was used to present the most commonly-used coping strategies to a new sample of PCa patients and to compare the effectiveness of those strategies. Methods: A total of 147 PCa patients completed a background questionnaire and the Prostate Cancer …
Breast Cancer Patients' Preferences For Information: Different Sources At Different Times?, Christopher Sharpley, Vicki Bitsika, David Christie
Breast Cancer Patients' Preferences For Information: Different Sources At Different Times?, Christopher Sharpley, Vicki Bitsika, David Christie
Vicki Bitsika
Introduction: Information given to breast cancer patients may not universally reduce anxiety and assist treament compliance. One possible reason could be that patient preferences for specific information sources may change over time.Objectives: To compare breast cancer patients' preferred formats for receiving education about their disease and treatment soon after diagnosis versus about two years after that time.Methods: An anonymous survey of 253 breast cancer patients' evaluations of alternative information formats was conducted within one month of diagnosis, and data were compared to those collected in a previous study from patients who were abut two years post-diagnosis.Results: There were discrepancies between …
Variability In Anxiety And Depression Over Time Following Diagnosis In Patients With Prostate Cancer, Christoper Sharpley, David Christie, Vicki Bitsika
Variability In Anxiety And Depression Over Time Following Diagnosis In Patients With Prostate Cancer, Christoper Sharpley, David Christie, Vicki Bitsika
Vicki Bitsika
To determine the presence and nature of variability in anxiety and depression in patients with prostate cancer (PCa) over 3 years following diagnosis, 442 patients with PCa completed standardized anxiety and depression inventories via survey between 1 and 36 months after receiving their initial diagnosis. Data were analyzed from a series of 3-month cohorts, and results indicated that total scores and incidence of clinically significant anxiety and depression varied over time, but that this variability was restricted to specific subfactors of anxiety and depression. Provision of effective psychological treatment to patients with PCa is discussed.
Incidence And Nature Of Anxiety-Depression Comorbidity In Prostate Cancer Patients, Christoper Sharpley, Vicki Bitsika, David Christie
Incidence And Nature Of Anxiety-Depression Comorbidity In Prostate Cancer Patients, Christoper Sharpley, Vicki Bitsika, David Christie
Vicki Bitsika
Background: The aim of this study was to measure the incidence of anxiety-depression comorbidity among a sample of prostate cancer (PCa) patients and to investigate the total score, factor score and scale item differences across subgroups defined according to the presence of anxiety and/or depression. Methods: 491 PCa patients who had received their initial diagnosis between 1 and 113 months previously completed a survey of background variables, as well as the Zung Self-Rating Anxiety and Depression Scales (SAS, SDS). Results: Incidence of anxiety-depression comorbidity was nearly 16%, and higher than that previously reported in other samples. Although the directional differences …
School-Based Cancer Education Programs: An Opportunity To Affect The National Cancer Problem, Donald Iverson, J Scheer
School-Based Cancer Education Programs: An Opportunity To Affect The National Cancer Problem, Donald Iverson, J Scheer
Don C. Iverson
No abstract provided.
'Why I Feel Bad': Refinement On The Effects Of Prostate Cancer Upon Lifestyle Questionnaire And An Initial Exploration Of Its Links With Anxiety And Depression Among Prostate Cancer Patients, Christopher Sharpley, Vicki Bitsika, David Christie
'Why I Feel Bad': Refinement On The Effects Of Prostate Cancer Upon Lifestyle Questionnaire And An Initial Exploration Of Its Links With Anxiety And Depression Among Prostate Cancer Patients, Christopher Sharpley, Vicki Bitsika, David Christie
Vicki Bitsika
Objective: To psychometrically refine a standardized scale for identifying those lifestyle changes that were most likely to contribute to anxiety and depression among prostate cancer (PCa) patients.
Methods: Three hundred and eighty-one PCa patients who had received their initial diagnosis between one and 96 months completed a survey of background variables, anxiety and depression inventories and the 36-item Effects of Prostate Cancer upon Lifestyle Questionnaire (EPCLQ).
Results: Levels of anxiety (24%) and depression (26%) were similar to those previously reported for PCa patients. The EPCLQ was shown to have satisfactory psychometric properties and significantly predicted anxiety and depression scores and …