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Full-Text Articles in Social and Behavioral Sciences
Metals Analysis As A Tool For Understanding Headwater Health And Stream Processes In The Southern Appalachian Coal Region: An Exploratory Analysis, Alice Jones, Lee Powell, James Fox
Metals Analysis As A Tool For Understanding Headwater Health And Stream Processes In The Southern Appalachian Coal Region: An Exploratory Analysis, Alice Jones, Lee Powell, James Fox
Alice Jones
Major and trace metal analysis was applied to four coal-country headwater streams to better understand the fate of metals in headwater streams affected by mining over time and to determine headwater health. The study watersheds were located in southeastern Kentucky and consisted of an active mine site, a site mined prior to the passage of the Surface Mine Control and Reclamation Act of 1977 (SMCRA), a post-SMCRA reclaimed mine site, and an undisturbed forest control site. Dissolved water metals and suspended sediment metals were sampled at each source, middle, and outlet. Samples were analyzed on an ICP-OES, and spatial trends …
The Extracellular Chaperone Clusterin Influences Amyloid Formation And Toxicity By Interacting With Pre-Fibrillar Structures, Justin Yerbury, Stephen Poon, Sarah Meehan, Brianna Thompson, Janet Kumita, Christopher Dobson, Mark Wilson
The Extracellular Chaperone Clusterin Influences Amyloid Formation And Toxicity By Interacting With Pre-Fibrillar Structures, Justin Yerbury, Stephen Poon, Sarah Meehan, Brianna Thompson, Janet Kumita, Christopher Dobson, Mark Wilson
Mark R Wilson
Clusterin is an extracellular chaperone present in all disease-associated extracellular amyloid deposits, however, its roles in amyloid formation and protein deposition in vivo are poorly understood. The current study initially aimed to characterise the effects of clusterin on amyloid formation in vitro by a panel of eight protein substrates. Two of the substrates (Alzheimer's beta peptide and a PI3-SH3 domain) were then used in further experiments to examine the effects of clusterin on amyloid cytotoxicity and to probe the mechanism of clusterin action. We show that clusterin exerts potent effects on amyloid formation, the nature and extent of which vary …