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Effect Of Apolipoprotein Ε4 On Hippocampal And Brain Volume In Intractable Temporal Lobe Epilepsy, Robyn Busch, Darlene Floden, Tara Lineweaver, Jessica Chapin, Kanjana Ungwongse, Tim Wehner, Ramon Diaz-Arrastia, Imad Najm

Tara T. Lineweaver

This study investigated the relationship between the apolipoprotein (APOE) ε4 allele and brain volumes in patients with medically intractable temporal lobe epilepsy (TLE). MRI-based volumetric analyses of the hippocampi, cerebral hemispheres, and whole brain were conducted in 59 patients with TLE (31 with left TLE, 28 with right TLE) with hippocampal sclerosis (HS). There were no differences in hippocampal, hemispheric, or whole brain volumes as a function of ε4 status even after correcting for hemispheric and total brain volumes. However, APOE ε4 carriers showed a trend toward having a smaller discrepancy between ipsilateral and contralateral hippocampal volumes than patients without …