Social and Behavioral Sciences Commons^™

Conformation Dependent Monoclonal Antibodies Distinguish Different Replicating Strains Or Conformers Of Prefibrillar Aβ Oligomers, Rakez Kayed, Isabel Canto, Leonid Breydo, Suhail Rasool, Tamas Lukacsovich, Jessica Wu, Ricardo Albay, Anna Pensalfini, Stephen Yeung, Elizabeth Head, J. Lawrence Marsh, Charles Glabe

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Age-related neurodegenerative diseases share a number of important pathological features, such as accumulation of misfolded proteins as amyloid oligomers and fibrils. Recent evidence suggests that soluble amyloid oligomers and not the insoluble amyloid fibrils may represent the primary pathological species of protein aggregates.

RESULTS: We have produced several monoclonal antibodies that specifically recognize prefibrillar oligomers and do not recognize amyloid fibrils, monomer or natively folded proteins. Like the polyclonal antisera, the individual monoclonals recognize generic epitopes that do not depend on a specific linear amino acid sequence, but they display distinct preferences for different subsets of prefibrillar oligomers. Immunological …

Criminal Offending Among Respondents To Protective Orders: Crime Types And Patterns That Predict Victim Risk, Carol E. Jordan, Adam J. Pritchard, Danielle Duckett, Richard Charnigo

Office for Policy Studies on Violence Against Women Publications

Research has shown that respondents to protective orders have robust criminal histories and that criminal offending behavior often follows issuance of a protective order. Nonetheless, the specific nature of the association between protective orders and criminal offending remains unclear. This study uses two classes of statistical models to more clearly delineate that relationship. The models reveal factors and characteristics that appear to be associated with offending and protective order issuance and provide indications about when a victim is most at risk and when the justice system should be most ready to provide immediate protection.

The Appalachian Regional Development Act And Economic Change, James P. Ziliak

University of Kentucky Center for Poverty Research Discussion Paper Series

The Appalachian Regional Development Act of 1965 is one of the longest serving place-based regional development programs in the U.S., and is the largest in terms of geographic scope. I use county-level data from the 1960 thru 2000 Decennial Censuses to evaluate the effect of ARDA on poverty rates and real per capita incomes in Appalachia. The intent to treat parameter is identified in a difference-in-difference-in-difference framework by comparing outcomes in Appalachia to her border counties. Additional knowledge of which counties were solely eligible for highway development funds under ARDA from those counties eligible for both highway as well as …

Deficient Liver Biosynthesis Of Docosahexaenoic Acid Correlates With Cognitive Impairment In Alzheimer's Disease, Giuseppe Astarita, Kwang-Mook Jung, Nicole C. Berchtold, Vinh Q. Nguyen, Daniel L. Gillen, Elizabeth Head, Carl W. Cotman, Daniele Piomelli

Sanders-Brown Center on Aging Faculty Publications

Reduced brain levels of docosahexaenoic acid (C22:6n-3), a neurotrophic and neuroprotective fatty acid, may contribute to cognitive decline in Alzheimer's disease. Here, we investigated whether the liver enzyme system that provides docosahexaenoic acid to the brain is dysfunctional in this disease. Docosahexaenoic acid levels were reduced in temporal cortex, mid-frontal cortex and cerebellum of subjects with Alzheimer's disease, compared to control subjects (P = 0.007). Mini Mental State Examination (MMSE) scores positively correlated with docosahexaenoic/α-linolenic ratios in temporal cortex (P = 0.005) and mid-frontal cortex (P = 0.018), but not cerebellum. Similarly, liver docosahexaenoic acid content was lower in Alzheimer's …

Does Race Based Redistricting Matter For Policy?, Ebonya Washington

University of Kentucky Center for Poverty Research Discussion Paper Series

During the 1990 congressional redistricting many states were mandated to create additional majority minority-resident districts in order to elect more minorities to Congress. Civil rights groups and Republicans cheered. The Party views Democratic districts stripped of Black voters as opportunities to repaint blue districts red. The academic literature agrees, attributing the Republican return to House control in 1994 to race based redistricting. However, this literature generally focuses on the district as the unit of analysis, a focus that is too narrow, as some districts gain Black residents while others lose them. I focus on states, the level at which redistricting …

Poverty, Inequality And Cost Of Living Differences, Enrico Moretti

University of Kentucky Center for Poverty Research Discussion Paper Series

Metropolitan areas in the US are characterized by enormous differences in average income, earnings, and factor productivity. The income of individuals located in metropolitan areas at the top of the income distribution is more than double the income of observationally similar individuals located in metropolitan areas at the bottom of the distribution. These differences reflect, at least in part, variation in local productivity.

Relationship And Injury Trends In The Homicide Of Women Across The Lifespan: A Research Note, Carol E. Jordan, Adam J. Pritchard, Danielle Duckett, Pamela Wilcox, Tracey Corey, Mandy Combest

Office for Policy Studies on Violence Against Women Publications

In 2006, more than 3,600 women in the United States lost their lives to homicide. Descriptive data regarding homicides of women are beginning to reveal important complexities regarding victim–offender relationships, severity of injury, and age of female homicide victim. More specifically, there is some indication that the correlation between victim–offender relationship and injury severity may be conditional, depending on victim age. This retrospective review accessed medical examiner records of female homicide victims from 2002 through 2004, and its findings offer additional illumination on the trends in associations of injury and relationship variables in the homicide of women over their life …

The Impact Of U.S. Family Planning Programs On Fertility And Mortality: Evidence From The War On Poverty And Title X, Martha Bailey

University of Kentucky Center for Poverty Research Discussion Paper Series

Over forty years ago, the U.S. government adopted a policy of funding domestic family planning services, and the effects of these programs have been debated ever since. Within an event-study framework, I exploit community-level variation in the timing of federal grants for family planning services under the Economic Opportunity Act (1965 to 1974) and Title X (1970 to 1980) to evaluate their impact. The results provide robust evidence that federal family planning grants reduced birth rates in funded communities by four percent within six years. I find no evidence that family planning grants reduced maternal or infant mortality rates.

Bodies Of Knowledge: Considerations Of Science, Exercise, Food And Body Politics, Ben Agger

disClosure: A Journal of Social Theory

No abstract provided.

Celebrity Culture And The Rise Of The Ordinary: An Interview With Joshua Gamson, David Hoopes, Drew Heverin

disClosure: A Journal of Social Theory

No abstract provided.

Omega-3 Fatty Acids: Potential Role In The Management Of Early Alzheimer's Disease, Gregory A. Jicha, William R. Markesbery

Sanders-Brown Center on Aging Faculty Publications

Omega-3 fatty acids are essential for brain growth and development. They play an important role throughout life, as critical modulators of neuronal function and regulation of oxidative stress mechanisms, in brain health and disease. Docosahexanoic acid (DHA), the major omega-3 fatty acid found in neurons, has taken on a central role as a target for therapeutic intervention in Alzheimer's disease (AD). A plethora of in vitro, animal model, and human data, gathered over the past decade, highlight the important role DHA may play in the development of a variety of neurological and psychiatric disorders, including AD. Cross sectional and prospective …

Notes On Poverty Traps And Appalachia, Steven Durlauf

University of Kentucky Center for Poverty Research Discussion Paper Series

In these notes, I provide some general ideas on how to conceptualize poverty traps and speculate on their applicability to understanding Appalachian poverty. My goal is to stimulate thinking on Appalachia that exploits contemporary perspectives in economics on the sources of persistent poverty and inequality. To do this, I focus on both the theory of poverty traps as well as issues in the econometric assessment of their empirical salience.

Assessing The Impact Of A Modernized Application Process On Florida’S Food Stamp Caseload, Colleen Heflin, Peter Mueser

University of Kentucky Center for Poverty Research Discussion Paper Series

In 2005, Florida implemented an internet-based service delivery system for eligibility determination in public assistance programs, including the Food Stamp, Temporary Assistance for Needy Families (TANF), and the Medicaid programs. At the same time, Florida switched from a caseworker model to a technology-driven model and decreased staffing levels of employees involved in social service delivery. We conduct an evaluative case study of the effects of these policy changes on the Food Stamp caseload. In particular, we consider the impact on applications and the flows onto and off of the program. To answer these questions, we use administrative data from the …

Tobacco-Free Prison Policies And Health Outcomes Among Inmates, Alison R. Connell

University of Kentucky Doctoral Dissertations

This study was the first to examine the effect of tobacco policies in prisons on the health of inmates. Kentucky has two types of tobacco policies in its 16 state prisons: indoor smoke-free policies, where smoking is allowed outdoors and tobacco-free policies, in which no tobacco of any kind is allowed on the grounds of the prison. The smoking rate of inmates is three times higher than that of current smokers in the non-incarcerated population which results in high rates of tobacco-related health conditions such as heart disease and lung cancer.

A literature review discussed the evolution of tobacco policies …

Lifting As We Climb: Experiences Of Black Diversity Officers At Three Predominantly White Institutions In Kentucky, Erica Nićcole Johnson

University of Kentucky Doctoral Dissertations

Recently, colleges and universities across the country have created executive level positions responsible for institutional diversity. The origins of this work within higher education lay in the civil rights movements and its consequences for desegregation of higher education. Early diversity officer positions usually resided within student affairs. However, as the responsibilities of these offices have changed, the reporting lines have also changed such that diversity officers are now commonly situated within academic affairs. This exploratory study examines these administrative positions responsible for diversity at southern white institutions. The research takes an in-depth look at how these positions have shifted over …

Face To Face Versus Computer-Mediated Communication: Couples Satisfaction And Experience Across Conditions, Martha Perry

University of Kentucky Master's Theses

This mixed method study examined differences in how face to face (FtF) and computer-mediated communication (CMC) were experienced for individuals communicating with their romantic partner. Forty-four individuals (22 couples) engaged in discussions in both FtF and CMC conditions in a laboratory environment, measuring communication satisfaction as an indicator of experience. Eight couples were also randomly selected to participate in interviews and their reports were used to add depth to the analyses and further inform the findings. Participants reported similar levels of satisfaction across communication conditions, which extends previous literature suggesting that users are able to adapt to text-based channels of …

Nativist Notions: The Effects Of Anti-Immigration Parties On Mainstream Conservative Parties In Western European Democracies, Kathleen Gish

University of Kentucky Master's Theses

This is an analysis of flank and shift effects in political sociology that focuses on anti-immigrant parties in eight European countries. In a positive radical flank effect the radical party makes the moderate and mildly-threatening parties look good. In turn, that moderate party then gains power or at least many of their ends. A negative radical flank effect occurs when the actual or perceived association of the moderate party with the radical party causes the moderate party to lose support. Radical shift effects are when the moderate or conservative party shifts its policy toward the radical direction. In this case, …

"Surely It Deserves A Name:" Homosexual Discourse Among Ellis, Carpenter, And Symonds, Jonathan E. Coleman

University of Kentucky Master's Theses

This thesis argues that British scholars Havelock Ellis, John Addington Symonds, and Edward Carpenter viewed themselves as somewhat rebellious, attempting to reconstruct norms of sexuality, particularly those concerning homosexuality. To do so, they invoked the well‐established constructions of class, gender, and sex. Nevertheless, in spite of their attempts problematize these constructions, they simultaneously worked within and reinforced them. Ellis, Carpenter and Symonds desired to change widelyheld perceptions of homosexuality and while doing so, alter notions of class, gender, and sex. These scholars asserted that homosexual relationships could exist across the divides of the class‐system, helping to engender a greater cross‐class …

Three Worlds Of Western Punishment: A Regime Theory Of Cross-National Incarceration Rate Variation, 1960-2002, Matthew Demichele

University of Kentucky Doctoral Dissertations

This dissertation offers an explanation of cross national incarceration rate variation for 17 industrialized countries for the second half of the 20^th century. Both historical case studies and time-series cross-section analyses are used to provide an institutional explanation of incarceration rate differences. Borrowing from Weber’s Sociology of Law and comparative legal scholarship, it is suggested that three types of legal thinking exist among western democracies—Common, Romano-Germanic, and Nordic law. A regime approach commonly applied in political economic explanations of welfare state development is used to quantify the legal and criminal justice institutional differences between 1960 and 2002 to assert …

Down Syndrome And Sexuality, Maria José Carvalho Sant'anna, Bruna Marques Bononi, André Chao Vasconcellos De Oliveira, Tadeu Silveira Renattini, Carla Franchi Pinto, Maria Lucia Passarelli, Veronica Coates, Hatim A. Omar

Pediatrics Faculty Publications

In recent years important gains and changes have been observed in the life of teenagers with Down syndrome (DS) with increased inclusion into society. This chapter will discuss adolescence and sexuality in teenagers with DS from a descriptive study of 50 patients with DS between the ages of 10 and 20 years. The mean age was 13.5 years, 50% females. 86% went to school with 62.2% in school for over six years. Of the patients that attended school, 60% went to special education school and only 10% read and wrote correctly. In evaluation of autonomy, 66% took shower, 78% performed …

Quality Of Life And Adolescents In Rural Kentucky, Hatim A. Omar, Søren Ventegodt, Joav Merrick

Pediatrics Faculty Publications

In many rural areas in Kentucky, adolescents lack the basic assets for a good quality of life, such as having caring adults, a safe place and useful activities after school. In this chapter we analyze data from middle and high school students referred to a comprehensive school based health promotion center (SBHPC). From August 2006 to February 2008, a total of 382 students (200 female, 182 male, aged 12-18 years) were referred to the SBHPC for help. Only two (0.5%) students had two parents living with them and 12 (3.1 %) had safe, organized after school activities. 19.9% of the …

Quality Of Life And Persons With Intellectual Disability: Can We Measure Qol In This Population?, Søren Ventegodt, Hatim A. Omar, Flemming Struve, Tove K. Nielsen, Isack Kandel, Joav Merrick

Pediatrics Faculty Publications

Quality of life (QOL) has been discussed by professionals working with persons with intellectual disability (ID) for some time, but since QOL is concerned with subjective well-being, satisfaction and happiness, how is it possible to measure, when the person in question is unable to communicate? Consciousness is believed to be an internal and personal thing, but we have done the simple experiment to ask observers to rate QOL of another person, also in sub dimensions like self-assessed physical and mental health, relationship with self, self-assessed sexual ability, self-assessed social ability, and we have found that people are able to assess …

State Employment Protection Statutes For Victims Of Domestic Violence As An Employment Matter, Jennifer E. Swanberg, Mamta U. Ojha

University of Kentucky Center for Poverty Research Discussion Paper Series

Evidence indicates that domestic violence has negative consequences on victims’ employment; yet employers lag in recognizing this as a workplace issue. To address the problem, some states have established several policy solutions. To understand the scope of the public sector’s response to domestic violence as a workplace issue, a content analysis of state-level employment protection policies for domestic violence victims (N=369) was conducted. Results indicate three broad policy categories: 1) policies that offer work leave for victims; 2) policies that aim to reduce employment discrimination of domestic violence victims; and 3) policies that aim to increase awareness and safety in …

What About These Children? Assessing Poverty Among The ‘Hidden Population’ Of Multiracial Children In Single-Mother Families, Jenifer Bratter, Sarah Damaske

University of Kentucky Center for Poverty Research Discussion Paper Series

Capturing the conditions of children of color living in single-parent families has become more complex due to the growing presence of interracial households. This analysis assesses the size and poverty status of single-female headed families housing multiracial children. Using data from the 2000 Census, we find that 9 percent of female-headed families house either children who are classified with more than one race or are classified as a single race different than their mother’s compared to only 3 percent of married couple families. Logistic regression analyses assessing the odds of poverty status for families finds that being a multiracial family …

The Vortex Of Labor, Thomas Janoski, Christopher Oliver

Sociology White Papers

Three factors constitute the new global division of labor that causes structural unemployment in advanced industrialized countries: (1) Globalization has increased outsourcing and off-shoring with manufacturing jobs and white collar work moving overseas. (2) Lean production has moved throughout the manufacturing industries of the world, with the service industries following behind. Lean production reduces jobs but can also create some jobs. (3) Advanced technologies reduce old jobs (e.g., newspapers, post office, etc.) but also create new jobs. The internet allows jobs to be done from anywhere in the world, which aids off-shoring, and automation reduces jobs but creates a few …

Household Living Arrangements And Economic Resources Among Mexican Immigrant Families With Children, Mark A. Leach

University of Kentucky Center for Poverty Research Discussion Paper Series

Using data from the 2000 Census, this study examines the relationship between household living arrangements and economic resources among Mexican immigrant families with children. I model separately the relationships between family income and household structure and proportion of total household income contributed and household structure. The results show that families that coreside with extended kin and non-kin have higher incomes, all else equal, relative to those that reside in single-family households. In addition, Mexican immigrant families that reside in extendedhousehold living arrangements contribute about three quarters of total household income. While families may gain some economic efficiency through extended household …

Social Categories And Health Care Outcomes: African American Women And Hiv Survival In The Urban South, Alyson J. O'Daniel

University of Kentucky Doctoral Dissertations

This ethnographic research examines the daily life and institutional conditions under which low-income Black women in urban North Carolina perceived and attended to HIV health-related needs. I focus specifically on the interplay among women’s living conditions, programmatic service needs, and their strategies for navigating the local system of care to explore and refine the categorical label “low income.” I found that there were significant differences among study participants in terms of their monthly incomes and financial resources, housing quality and status, and personal experiences with incarceration and substance abuse. The economic differences among women translated into social differences within the …

Exploring Arts Organizations As A Catalyst For Community Development, Amy Carrington

University of Kentucky Master's Theses

The purpose of this project was to examine the arts as a positive change agent for community development. Exploring how and for what purpose nonprofit arts organizations can create social capital can provide insight on how the arts industry can be a leader in the transformation of communities and regions around the globe. The perspectives of artists, community developers, sponsors and beneficiaries of the arts provided insight on how and in what ways the arts can evoke change by building connections and inspiring participation. Community development theorist Bhattacharyya (2004) distinguished community development from related fields such as economic development and …

Geographies Of Co2Lonialism And Hope In The Northwest Pacific Frontier Territory-Region Of Ecuador, Julianne Adams Hazlewood

University of Kentucky Doctoral Dissertations

This dissertation investigates the human dimensions of environmental transformations spurred by international climate change mitigation agreements—such as the Kyoto Protocol—that encourage lowering greenhouse gas emissions with ‘green’ market strategies like biofuel and ecological services development projects. It is methodologically grounded in “collaborative activist geographical methods” and theoretically based at the nexus of development, political ecologies, neoliberalization of Nature, and geographies of hope literatures. It examines the contradictory and complex ways that state “climate change mitigation development” projects surround and infiltrate the Indigenous and Afro-ecuadorian ancestral territories of the canton of San Lorenzo (Esmeraldas Province), located in the “Northwest Pacific Fronter …

A Non-Marital, Romantic Relationship Dissolution Study, Nicole B. Stork-Hestad

University of Kentucky Master's Theses

The present study examines three non-marital, romantic relationship dissolution types: (1) normal dyadic dissolution, (2) fatal attraction dissolution, and (3) social allergen dissolution among a sample of 321 emerging adults, who are between ages eighteen and twenty-nine. Results of an online survey revealed that normal dyadic dissolution occurred in 62%, social allergen dissolution occurred in 27%, and fatal attraction dissolution occurred in 11% of the participants’ relational demises. Results also revealed that there is a surprising amount of overlap between the three dissolution types, and that age is not specifically correlated with a particular dissolution type. However, there are two …