Social and Behavioral Sciences Commons^™

Cardiovascular Disease And Type 2 Diabetes In Evolutionary Perspective: A Critical Role For Helminths?, Michael D. Gurven, Benjamin C. Trumble, Jonathan Stieglitz, Aaron D. Blackwell, David E. Michalik, Caleb E. Finch, Hillard Kaplan

ESI Publications

Heart disease and type 2 diabetes are commonly believed to be rare among contemporary subsistencelevel human populations, and by extension prehistoric populations. Although some caveats remain, evidence shows these diseases to be unusual among well-studied hunter-gatherers and other subsistence populations with minimal access to healthcare. Here we expand on a relatively new proposal for why these and other populations may not show major signs of these diseases. Chronic infections, especially helminths, may offer protection against heart disease and diabetes through direct and indirect pathways. As part of a strategy to insure their own survival and reproduction, helminths exert multiple cardio-protective …