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Full-Text Articles in Social and Behavioral Sciences
Vaccination With Recombinant Aspartic Hemoglobinase Reduces Parasitic Load And Blood Loss After Hookworm Infection In Dogs, Alex Loukas, Jeffrey M. Bethony, Susana Mendez, Ricardo T. Fujiwara, Gaddam Narsa Goud, Najju Ranjit, Bin Zhan, Karen Jones, Maria Elena Bottazzi, Peter J. Hotez
Vaccination With Recombinant Aspartic Hemoglobinase Reduces Parasitic Load And Blood Loss After Hookworm Infection In Dogs, Alex Loukas, Jeffrey M. Bethony, Susana Mendez, Ricardo T. Fujiwara, Gaddam Narsa Goud, Najju Ranjit, Bin Zhan, Karen Jones, Maria Elena Bottazzi, Peter J. Hotez
Health Policy and Management Faculty Publications
Background
Hookworms infect 730 million people in developing countries where they are a leading cause of intestinal blood loss and iron-deficiency anemia. At the site of attachment to the host, adult hookworms ingest blood and lyse the erythrocytes to release hemoglobin. The parasites subsequently digest hemoglobin in their intestines using a cascade of proteolysis that begins with the Ancylostoma caninum aspartic protease 1, APR-1.
Methods and Findings
We show that vaccination of dogs with recombinant Ac-APR-1 induced antibody and cellular responses and resulted in significantly reduced hookworm burdens (p = 0.056) and fecal egg counts (p = …