Open Access. Powered by Scholars. Published by Universities.®
Social and Behavioral Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Social and Behavioral Sciences
Predicting Alcohol Consumption In Adolescent Rhesus Macaques (Macaca Mulatta), Andrea Nichole Sorenson
Predicting Alcohol Consumption In Adolescent Rhesus Macaques (Macaca Mulatta), Andrea Nichole Sorenson
Theses and Dissertations
Numerous studies show that a low level of response to the intoxicating effects of alcohol is considered a risk factor for future alcoholism. However, assessing this sensitivity usually requires administering a controlled dose of alcohol, which has a number of inherent problems. Early observations in our lab suggest that the response to anesthetics that show cross tolerance with alcohol, like ketamine, are blunted in nonhuman primates at risk for high alcohol intake, and may be a viable measure of future alcohol consumption. This study was designed to test potential predictors of future alcohol consumption using the change in ketamine across …
Characterization Of The Hippocampal Acetylcholine System In A Rodent Model Of Fetal Alcohol Syndrome, Amy Elizabeth Perkins
Characterization Of The Hippocampal Acetylcholine System In A Rodent Model Of Fetal Alcohol Syndrome, Amy Elizabeth Perkins
Theses and Dissertations
Fetal alcohol spectrum disorders (FASD) are a major public health concern, as it is estimated that 2-5% of children are exposed to alcohol at some point during prenatal development. FASD have been shown to cause damage to multiple brain regions, but research shows that the hippocampus is especially sensitive to alcohol exposure. This damage to the hippocampus explains, in part, deficits in learning and memory that are hallmark symptoms of FASD. The acetylcholine neurotransmitter system plays a major role in learning and memory, and the hippocampus is one of its main targets. This experiment used a rodent model of Fetal …