Social and Behavioral Sciences Commons^™

The Effects Of Progesterone Receptor On Development Of Serotonergic Circuits That Mediate Cognition, Heather Smith

Psychology

As the rate of premature births has been substantially increasing, progestin administration is becoming a common treatment for the prevention of preterm labor. However, not much is known regarding how these hormonal supplements may affect the development of the fetal brain. The developing brain is highly sensitive to progesterone as progesterone receptor (PR) is expressed in many regions during critical developmental periods. Steroid hormone receptors such as PR are powerful transcription factors and regulate gene expression to alter fundamental processes of neural development. During the developmental period of post-natal day one (P1) to P14 in rats, PR is transiently expressed …