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Examination Of Sex Differences And The Role Of Ovarian Hormones In Modulating Nicotine Withdrawal In Rats, Rodolfo Jesus Flores Garcia
Examination Of Sex Differences And The Role Of Ovarian Hormones In Modulating Nicotine Withdrawal In Rats, Rodolfo Jesus Flores Garcia
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Introduction: Aim 1 characterized sex differences and the role of ovarian hormones in physical signs and negative affective states produced by nicotine withdrawal in female, ovariectomized female (OVX), and male rats. We also compared nicotine withdrawal and corticosterone levels with estradiol (E2) and progesterone across the 4-day estrous cycle. Aim 2 validated the role of ovarian hormones in withdrawal in OVX females that received vehicle, E2, or E2+progesterone. Methods: Female rats received a sham surgery or an ovariectomy procedure. Fifteen days later, all rats were implanted with a pump that delivered nicotine for 14 days. On the test day, separate …