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Characterization Of The Behavioral And Neurochemical Effects Of Nicotine Withdrawal In Adolescent And Adult Rats., Luis Alberto Natividad
Characterization Of The Behavioral And Neurochemical Effects Of Nicotine Withdrawal In Adolescent And Adult Rats., Luis Alberto Natividad
Open Access Theses & Dissertations
Previous studies have demonstrated that the behavioral effects of nicotine withdrawal are lower in adolescent versus adult rats. However, the neurochemical mechanisms that mediate these developmental differences are presently unclear. Much work has shown that nicotine reward is mediated via enhanced dopamine neurotransmission in the mesolimbic pathway which originates in the ventral tegmental area (VTA) and terminates in several forebrain structures including the nucleus accumbens (NAcc). More recently, studies have shown that nicotine withdrawal produces a decrease in NAcc dopamine transmission, an effect that is believed to serve as a neurochemical marker of withdrawal in adult rodents. The goal of …