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Full-Text Articles in Social and Behavioral Sciences
Evaluation Of Α-Pyrrolidindovalerophenone (Α-Pvp) And Its Isomers In Male And Female Sprague-Dawley Rats Trained To Discriminate Mdpv, Kaley Cargile
Evaluation Of Α-Pyrrolidindovalerophenone (Α-Pvp) And Its Isomers In Male And Female Sprague-Dawley Rats Trained To Discriminate Mdpv, Kaley Cargile
Masters Theses
Recreational use of synthetic cathinones, 3,4-methylenedioxypyrovalerone (MDPV) and α‐pyrrolidinovalerophenone (α‐PVP), has become increasingly popular, thus prompting characterization of their behavioral and neurochemical effects. MDPV has been studied for several years now, though there is still much unknown about α‐PVP, and its isomers. The primary objective of this study was to characterize the discriminative effects of α‐PVP and its isomers in comparison to MDPV. Male and female Sprague-Dawley rats were trained to discriminate 0.5mg/kg MDPV from saline injections under a fixed ratio 20 (FR 20) schedule of food reinforcement. Substitution tests were conducted with MDPV (0.05-0.5mg/kg), α‐PVP (0.05-0.5mg/kg), (S)-α‐PVP (0.05-1mg/kg) and …
Combined Effects Of Mdma And Ethanol On Locomotor Activity And Place Conditioning In Male And Female Adolescent Sprague-Dawley Rats, Keli A. Herr
Masters Theses
MDMA, ("Ecstasy") is commonly abused in combination with ethanol (EtOH). Relatively few preclinical studies have investigated sex differences in animal models of polysubstance use. The current study employed a conditioned place preference (CPP) procedure to assess the behavioral effects of the co-administration ofMDMA /EtOH in 32 male and 32 female adolescent Sprague-Dawley rats. Following a 15 min habituation trial, eight 30-min conditioning trials were conducted in two- compartment chambers with different environmental cues. Before each drug conditioning trials, rats were administered intraperitoneal (i.p.) injections of MDMA(6.6 mg/kg), EtOH (1.5 g/kg), MDMA (6.6 mg/kg) and EtOH (1.5 g/kg), or saline. Prior …