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Full-Text Articles in Social and Behavioral Sciences
Cannabinoid Modulation Of Reinforcement Maintained By Stimulation Of The Medial Forebrain Bundle In C57bl/6j Mice, Jason Wiebelhaus
Cannabinoid Modulation Of Reinforcement Maintained By Stimulation Of The Medial Forebrain Bundle In C57bl/6j Mice, Jason Wiebelhaus
Theses and Dissertations
Cannabinoid agonists, including marijuana containing delta-9-tetrahydrocannabinol (THC), are found rewarding by humans. In addition to human self-reports and experimental studies that show marijuana is rewarding, contributions from preclinical studies also have implicated cannabinoid receptors in reward-motivated behavior. One way to assess these preclinical effects of cannabinoids is intracranial self-stimulation (ICSS), where an animal performs a response to receive electrical stimulation of a specific brain area or circuit known to be involved in reward. Drugs of abuse, such as psychomotor stimulants, facilitate responding for ICSS. While a few studies have shown facilitating effects of cannabinoids in rats, several have shown the …