Open Access. Powered by Scholars. Published by Universities.®
Social and Behavioral Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Social and Behavioral Sciences
The Effects Of Aniracetam Treatment On Cognitive Performance And Ampa Receptor Glur2 Subunit Expression After Moderate Fluid Percussion Injury In Rats, Anna Igorevna Baranova
The Effects Of Aniracetam Treatment On Cognitive Performance And Ampa Receptor Glur2 Subunit Expression After Moderate Fluid Percussion Injury In Rats, Anna Igorevna Baranova
Theses and Dissertations
In addition to the acute pathology produced by traumatic brain injury, there are chronic alterations that occur after the trauma, including a depressed state of neuronal activity (Feeney, 1991). This study included a preclinical testing of a novel treatment strategy focusing on increasing neuronal activity during the chronic hypofunctional posttraumatic stage. The present investigation tested the effects of repeated post-injury aniracetam administration on cognitive performance in the Morris water maze (MWM) and on the GluR2 - immunoreactivity and protein expression by Western blot analysis in the hippocampus. The first study examined the optimal dose of aniracetam in the MWM task. …