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Full-Text Articles in Social and Behavioral Sciences
The Role Of The Amygdala, Retrosplenial Cortex, And Medial Prefrontal Cortex In Trace Fear Extinction And Reconsolidation, Janine Lynn Kwapis
The Role Of The Amygdala, Retrosplenial Cortex, And Medial Prefrontal Cortex In Trace Fear Extinction And Reconsolidation, Janine Lynn Kwapis
Theses and Dissertations
A wealth of research has outlined the neural circuits responsible for the consolidation, reconsolidation, and extinction of standard "delay" fear conditioning, in which awareness is not required for learning. Far less is understood about the neural circuit supporting more complex, explicit associations. "Trace" fear conditioning is considered to be a rodent model of explicit fear because it relies on the cortex and hippocampus and requires explicit contingency awareness in humans for successful acquisition. In the current set of studies, we aimed to better characterize the neural circuit supporting the consolidation, reconsolidation, and extinction of trace fear in order to better …
The Role Of Nmda Receptors In Extinction Of Cocaine Self-Administration, Madalyn Hafenbreidel
The Role Of Nmda Receptors In Extinction Of Cocaine Self-Administration, Madalyn Hafenbreidel
Theses and Dissertations
Relapse is highly prevalent among recovering addicts, and can be triggered by associations made between the rewarding effects of the drug and cues, such as drug paraphernalia or contexts. Inhibiting these associations, through new extinction learning, could help reduce relapse rates. Extinction is formed in phases, like other types of memory. The memory first is acquired in short-term memory, then is consolidated into long-term storage from which it can be retrieved at a later time (Quirk & Mueller, 2008). NMDA receptors are necessary for extinction in other paradigms (Santini, Muller, & Quirk, 2001), and we previously found that blocking NMDA …