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Full-Text Articles in Social and Behavioral Sciences
Modulatory Effects Of Gaba(B) Receptor Facilitation In A Model Of Chronic Inflammation, Michael A. Langhardt, Jefferson Kinney
Modulatory Effects Of Gaba(B) Receptor Facilitation In A Model Of Chronic Inflammation, Michael A. Langhardt, Jefferson Kinney
McNair Poster Presentations
Inflammation within the brain (neuroinflammation) has been associated with a number of neurodegenerative diseases, including Alzheimerʼs disease (AD) (Solito et al., 2012). Within the brain, inflammation is defined broadly as prolonged activation of the brainʼs immune cells, known as glial cells. Excessive activation of glial cells within the brains of AD patients is a hallmark of the disease, however the mechanism by which this contributes to disease pathology is relatively unclear (Jo et al., 2014). Recently, studies have shown that glial cells, known as astrocytes, are able to synthesize and release the inhibitory neurotransmitter GABA (Charles et al., 2003). Further, …