Social and Behavioral Sciences Commons^™

Effects Of Vortioxetine On Biomarkers Associated With Glutamatergic Activity In An Ssri Insensitive Model Of Depression In Female Rats, N. Hlavacova, Y. Li, Alan Pehrson, Connie Sanchez, Isabel Bermudez-Diaz, Agnesa Csanova, Daniela Jezova, Michael Franklin

Department of Psychology Faculty Scholarship and Creative Works

The aim of this study was to investigate the antidepressant activity of vortioxetine in a tryptophan (TRP) depletion female rat model of depression and compare it to that of paroxetine using doses that fully occupy the serotonin transporter (SERT). We evaluated the effects of vortioxetine on potential biomarkers associated with TRP depletion including serum aldosterone, corticosterone and IL-6 levels together with indirect indicators of glutamate neurotransmission. Female Sprague-Dawley rats were randomized to control, low TRP, low TRP/paroxetine or low TRP/vortioxetine groups. Vortioxetine and paroxetine were administered via diet (10 mg/kg/day) and drinking water (10 mg/kg/day) respectively for 14 days. Vortioxetine …