Social and Behavioral Sciences Commons^™

Executive Functioning And Risk For Alzheimer's Disease In The Cognitively Intact: Family History Predicts Wisconsin Card Sorting Test Performance, Kathleen Hazlett, Christina Marie Figueroa, Kristy A. Nielson

Psychology Faculty Research and Publications

Alzheimer’s disease (AD) research typically focuses on memory. However, executive functioning (EF) deficits are also common among AD patients; these deficits are associated with decreased functioning in activities of daily living, an important criterion in diagnosing AD. A classic test of EF ability, the Wisconsin Card Sort Test (WCST), has demonstrated sensitivity to differentiating individuals with AD from healthy controls, discriminating AD groups based on disease severity, and distinguishing AD from other types of dementia. Such sensitivity to AD raises the possibility that the WCST is also sensitive to very early, preclinical differences between those who have heightened risk for …