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Social and Behavioral Sciences Commons™
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Articles 1 - 2 of 2
Full-Text Articles in Social and Behavioral Sciences
Brain Integrity And Cerebral Atrophy In Vietnam Combat Veterans With And Without Posttraumatic Stress Disorder, Bruce L. Brown, Dawson W. Hedges, G. William Thatcher, Pamela J. Bennett, Shabnam Sood, David Paulson, Sarah Creem-Regehr, Steven Allen, Jamie Johnson, Brooke Froelich, Erin D. Bigler
Brain Integrity And Cerebral Atrophy In Vietnam Combat Veterans With And Without Posttraumatic Stress Disorder, Bruce L. Brown, Dawson W. Hedges, G. William Thatcher, Pamela J. Bennett, Shabnam Sood, David Paulson, Sarah Creem-Regehr, Steven Allen, Jamie Johnson, Brooke Froelich, Erin D. Bigler
Faculty Publications
Posttraumatic stress disorder (PTSD) is associated with decreased hippocampal volume, but the relationship between trauma and brain morphology in the absence of PTSD is less clear. In this study, measures of brain integrity were determined by estimating gray and white matter regional brain volumes using structural magnetic resonance imaging in six patients with PTSD and in five controls with comparable trauma exposure but without clinical evidence of PTSD. The only statistically significant volume difference between groups was observed multivariately in the white matter of the right temporal lobe (superior temporal gyrus, fusiform gyrus, parahippocampal gyrus, white-matter stem, middle temporal gyrus, …
Conditional Discrimination And Reversal In Amnesia Subsequent To Hypoxic Brain Injury Or Anterior Communicating Artery Aneurysm Rupture, C. E. Myers, J. Deluca, Ramona O. Hopkins, M. A. Gluck
Conditional Discrimination And Reversal In Amnesia Subsequent To Hypoxic Brain Injury Or Anterior Communicating Artery Aneurysm Rupture, C. E. Myers, J. Deluca, Ramona O. Hopkins, M. A. Gluck
Faculty Publications
Human anterograde amnesia can develop following bilateral damage to the hippocampus and medial temporal lobes, as in hypoxic brain injury, or following damage to the basal forebrain, as following anterior communicating artery (ACoA) aneurysm rupture. In both cases, the mnestic deficit may be similar when assessed by standard neuropsychological measures. However, animal and computational models suggest that there are qualitative differences in the pattern of impaired and spared memory abilities following damage to hippocampus versus basal forebrain. Here, we show such a dissociation in human amnesia using a single two-stage task, involving conditional discrimination and reversal. Consistent with a prior …