Social and Behavioral Sciences Commons^™

Cortical Thickness In Neuropsychologically Near-Normal Schizophrenia, Derin J. Cobia, John G. Csernansky, Lei Wang

Faculty Publications

Schizophrenia is a chronic and potentially disabling disorder with widespread neuroanatomical abnormalities thought to be caused by progressive brain changes (Andreasen, 2010), and an equally wide variety of impairments in cognitive functioning (Palmer et al., 2009). In general, individuals with schizophrenia demonstrate significantly impaired performance on a full range of neuropsychological tasks, often reaching greater than one standard deviation below the norm (Dickinson et al., 2007). One particularly puzzling issue is that approximately 15–30% of schizophrenia patients have been found to perform in the normal range of neuropsychological functioning (Kremen et al., 2000; Palmer et al., 1997). Given hypothesized relationships …

The Serotonin Transporter Gene Linked Polymorphic Region Is Associated With The Behavioral Response To Repeated Stress Exposure In Infant Rhesus Macaques, Simona Spinelli, Melanie L. Schwandt, Stephen G. Lindell, Markus Heilig, Stephen J. Suomi, James Dee Higley, David Goldman, Christina S. Barr

Faculty Publications

The short allele of the serotonin transporter linked polymorphic region (5-HTTLPR) moderates the effects of stress on vulnerability to mood and anxiety disorders. The mechanism by which this occurs may relate to differential sensitivity to stressful life events. Here we explored whether 5- HTTLPR and sex affected behavioral responses to repeated maternal separation in infant rhesus macaques. Behaviors were collected during the acute (Day 1) and the chronic (Days 2–4) phases of the separation, and the effects of duration of separation (acute vs. chronic), genotype (long/long vs. short allele), and sex (male vs. female) on behavioral responses were analyzed across …

Oprm1 Gene Variation Influences Hypothalamic-Pituitary-Adrenal Axis Function In Response To A Variety Of Stressors In Rhesus Macaques, Melanie L. Schwandt, Stephen G. Lindell, James Dee Higley, Stephen J. Suomi, Markus Heilig, Christina S. Barr

Faculty Publications

The endogenous opioid system is involved in modulating a number of behavioral and physiological systems, including the hypothalamic-pituitary-adrenal (HPA) axis. In humans, a functional variant in the OPRM1 gene (OPRM1 A118G) is associated with a number of outcomes, including attenuated HPA axis responses to stress. A nonsynonymous variant (OPRM1 C77G) in the rhesus macaque has been shown to have similar effects in vivo to the human variant. The current study investigated whether OPRM1 C77G influences HPA axis response to stress in rhesus macaques. We analyzed plasma adrenocorticotropic hormone (ACTH) and cortisol levels measured in response to three different stressors: 1) …

How Does Noise Affect Amplitude And Latency Measurement Of Event-Related Potentials (Erps)? A Methodological Critique And Simulation Study, Scott A. Baldwin, Peter E. Clayson, Michael J. Larson

Faculty Publications

There is considerable variability in the quantification of event-related potential (ERP) amplitudes and latencies. Weexamined susceptibility of ERP quantification measures to incremental increases in background noise through publishedERP data and simulations. Measures included mean amplitude, adaptive mean, peak amplitude, peak latency, andcentroid latency. Results indicated mean amplitude was the most robust against increases in background noise. Theadaptive mean measure was more biased, but represented an efficient estimator of the true ERP signal particularly forindividual-subject latency variability. Strong evidence is provided against using peak amplitude. For latency measures,the peak latency measure was less biased and less efficient than the centroid latency …

Global Representation In Psychiatric Research, Bruce L. Brown, Michael Zhang, Dawson W. Hedges

Faculty Publications

To monitor global representation in the psychiatric literature, we compared publication rates in the ten psychiatric journals with the highest impact factors in 1998 and 2008 by world regions. In both 1998 and 2008, North America, Northern Europe, Western Europe and Oceania produced the majority of psychiatric research papers published in these journals, despite representing only a small fraction of the world’s population. This suggests that much of the world’s population continues to be underrepresented in highly influential psychiatric journals.

Association Between C-Reactive Protein And Cognitive Deficits In Elderly Men And Women: A Meta-Analysis, Bruce L. Brown, Dawson W. Hedges, Thomas J. Farrer

Faculty Publications

Abstract

Background: Certain risk factors for cognitive decline appear modifiable. A potentially modifiable marker of inflammation, C-reactive protein may be associated with cognitive deficits, although not all studies have found a relationship between C-reactive protein and cognitive ability. Further, few research papers have examined whether gender may affect any association between C-reactive protein and cognitive deficit.

Methods: To better understand the association between C-reactive protein, cognitive deficit, and gender in elderly people, we meta-analyzed cross-sectional studies that reported cognitive ability assessed by the Mini-Mental State Examination or an equivalent measure, C-reactive protein concentrations, and gender.

Results: While we identified no …

Forgiveness And Relationship Satisfaction: Mediating Mechanisms, Scott R. Braithwaite, Edward A. Selby, Frank D. Fincham

Faculty Publications

Although the ability to forgive transgressions has been linked to overall relationship satisfaction, the mechanisms that mediate this association have not been established. We propose that the tendency to forgive a romantic partner increases relationship satisfaction via increased relational effort and decreased negative conflict. In two studies, we used structural equations modeling to examine these variables as potential mechanisms that drive this association. In Study 1 (N = 523) and Study 2 (N = 446) we found that these variables significantly mediated the association between forgiveness and relationship satisfaction. The findings were robust when examined concurrently and longitudinally, across multiple …

Examining A Brief Suicide Screening Tool In Older Adults Engaging In Risky Alcohol Use, Scott R. Braithwaite, Jessica D. Ribeiro, Jon J. Peaff, Thomas E. Joiner

Faculty Publications

Alcohol misuse increases risk of suicidal behavior in older adults. TheDepressive Symptom Inventory-Suicidality Subscale (DSI-SS; Metalsky & Joiner,1997) and its relation to suicide attempt history was examined to see if it differedfor older adults as a function of their alcohol use. Structural equation modelingwas used in a sample (N= 1,061) of older adult outpatients to examine the scale’smeasurement invariance and population heterogeneity and its relation to suicideattempt history. Analyses supported the equivalence of the DSI-SS in risky andnonrisky drinkers. The DSI-SS significantly predicted past suicide attempts. Find-ings support the viability of the DSI-SS as suicide screening tool for older adults.

Subliminal Activation Of Social Ties Moderates Cardiovascular Reactivity During Acute Stress, Wendy C. Birmingham, Mckenzie Carlisle, Bert N. Uchino, David M. Sanbonmatsu, Timothy W. Smith, Matthew R. Cribbet, Kathleen C. Light, Allison A. Vaughn

Faculty Publications

Objective—The quality of one’s personal relationships has been reliably linked to important physical health outcomes, perhaps through the mechanism of physiological stress responses. Most studies of this mechanism have focused on whether more conscious interpersonal transactions influence cardiovascular reactivity. However, whether such relationships can be automatically activated in memory to influence physiological processes has not been determined. The primary aims of this study were to examine if subliminal activation of relationships could influence healthrelevant physiological processes, and to examine this question in the context of a more general relationship model that incorporates both positive and negative dimensions. Method—We randomly assigned …

Psychological Pathways Linking Social Support To Health Outcomes: A Visit With The “Ghosts” Of Research Past, Present, And Future, Wendy C. Birmingham, Bert N. Uchino, Kimberly Bowen, Mckenzie Carlisle

Faculty Publications

Contemporary models postulate the importance of psychological mechanisms linking perceived and received social support to physical health outcomes. In this review, we examine studies that directly tested the potential psychological mechanisms responsible for links between social support and health-relevant physiological processes (1980s to 2010). Inconsistent with existing theoretical models, no evidence was found that psychological mechanisms such as depression, perceived stress, and other affective processes are directly responsible for links between support and health. We discuss the importance of considering statistical/design issues, emerging conceptual perspectives, and limitations of our existing models for future research aimed at elucidating the psychological mechanisms …

Evaluative Threat And Ambulatory Blood Pressure: Cardiovascular Effects Of Social Stress In Daily Experience, Wendy C. Birmingham, Timothy W. Smith, Bert N. Uchino

Faculty Publications

Objective—Physiological effects of social evaluation are central in models of psychosocial influences on physical health. Experimental manipulations of evaluative threat evoke substantial cardiovascular and neuroendocrine responses in laboratory studies, but only preliminary evidence is available regarding naturally-occurring evaluative threats in daily life. In such non-experimental ambulatory studies, it is essential to distinguish effects of evaluative threat from related constructs known to alter stress, such as ability perceptions and concerns about appearance. Methods—94 married, working couples (mean age 29.2 years) completed a one-day (8am to 10pm) ambulatory blood pressure (ABP) protocol with random interval-contingent measurements using a Suntech monitor and Palm …

Knowing Your Partner Is Not Enough: Spousal Importance Moderates The Link Between Attitude Familiarity And Ambulatory Blood Pressure, Wendy C. Birmingham, Bert N. Uchino, David M. Sanbonmatsu

Faculty Publications

Close relationships have been linked to cardiovascular morbidity and mortality. More research is needed, however, on the social and biological processes responsible for such links. In this study, we examined the role of relationship-based attitudinal processes (i.e., attitude familiarity and partner importance) on ambulatory blood pressure during daily life. Forty-seven married couples completed a questionnaire regarding their own attitudes, perceptions of their partner’s attitudes, and perceptions of partner importance. They also underwent a 1-day ambulatory assessments of daily spousal interactions and blood pressure. Partner importance was related to better interpersonal functioning (e.g., partner responsiveness) and lower ambulatory systolic blood pressure. …

Specific Dimensions Of Perceived Support And Ambulatory Blood Pressure: Which Support Functions Appear Most Beneficial And For Whom?, Wendy C. Birmingham, Kimberly S. Bowen, Bert N. Uchino, Mckenzie Carlisle, Timothy W. Smith, Kathleen C. Light

Faculty Publications

Perceived support has been related to lower cardiovascular morbidity and mortality. However, little is known about the specific functional components of support responsible for such links. We tested if emotional, informational, tangible, and belonging support predicted ambulatory blood pressure (ABP) and interpersonal interactions (e.g., responsiveness), and if such links were moderated by gender. In this study, 94 married couples underwent 12 h of ABP monitoring during daily life which included a night at home with their spouse. They completed a short-form of the interpersonal support evaluation list that provides information on total (global) support, as well as specific dimensions of …

The Effects Of Family Therapies Foradolescent Delinquency And Substanceabuse: A Meta-Analysis, Scott A. Baldwin, Sarah Christian, Arjan Berkeljon, William R. Shadish, Roy Bean

Faculty Publications

This meta-analysis summarizes results from k = 24 studies comparing either BriefStrategic Family Therapy, Functional Family Therapy, Multidimensional Family Therapy,or Multisystemic Therapy to either treatment-as-usual, an alternative therapy, or a controlgroup in the treatment of adolescent substance abuse and delinquency. Additionally, theauthors reviewed and applied three advanced meta-analysis methods including influenceanalysis, multivariate meta-analysis, and publication bias analyses. The results suggestedthat as a group the four family therapies had statistically significant, but modest effects ascompared to treatment-as-usual (d= 0.21;k= 11) and as compared to alternative thera-pies (d= 0.26;k= 11). The effect of family therapy compared to control was larger(d= 0.70;k= 4) …