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Full-Text Articles in Social and Behavioral Sciences
Longitudinal Changes In Global Brain Volume Between 79 And 409 Days After Traumatic Brain Injury: Relationship With Duration Of Coma, Mehul A. Trivedi, Michael A. Ward, Timothy M. Hess, Shawn D. Gale, Robert J. Dempsey, Howard A. Rowley, Sterling C. Johnson
Longitudinal Changes In Global Brain Volume Between 79 And 409 Days After Traumatic Brain Injury: Relationship With Duration Of Coma, Mehul A. Trivedi, Michael A. Ward, Timothy M. Hess, Shawn D. Gale, Robert J. Dempsey, Howard A. Rowley, Sterling C. Johnson
Faculty Publications
Neuropathological and experimental animal studies indicate that traumatic brain injury (TBI) results in long-term, neurodegenerative changes. Structural image evaluation using normalization of atrophy (SIENA) offers an automated analysis of the subtle changes in percent brain volume change (%BVC) associated with TBI. In the present study, SIENA was used to evaluate %BVC in individuals who had sustained a mild to severe TBI. We obtained 3D-T1 weighted anatomical MRI scans approximately 79 days and again 409 days post-injury. TBI patients (n= 37) displayed significantly greater decline in %BVC (-1.43%) relative to a normal comparison group (+ 0.1%, n=30). Greater %BVC was associated …