Social and Behavioral Sciences Commons^™

Rapamycin Rescues Vascular, Metabolic And Learning Deficits In Apolipoprotein E4 Transgenic Mice With Pre-Symptomatic Alzheimer’S Disease, Ai-Ling Lin, Jordan B. Jahrling, Wei Zhang, Nicholas Derosa, Vikas Bakshi, Peter Romero, Veronica Galvan, Arlan Richardson

Sanders-Brown Center on Aging Faculty Publications

Apolipoprotein E ɛ4 allele is a common susceptibility gene for late-onset Alzheimer's disease. Brain vascular and metabolic deficits can occur in cognitively normal apolipoprotein E ɛ4 carriers decades before the onset of Alzheimer's disease. The goal of this study was to determine whether early intervention using rapamycin could restore neurovascular and neurometabolic functions, and thus impede pathological progression of Alzheimer's disease-like symptoms in pre-symptomatic Apolipoprotein E ɛ4 transgenic mice. Using in vivo, multimodal neuroimaging, we found that apolipoprotein E ɛ4 mice treated with rapamycin had restored cerebral blood flow, blood–brain barrier integrity and glucose metabolism, compared …

Prescription For Critical Thinking: A Discussion Of Psychotropic Medication And Counseling, Barton W. Biggs

Educational Specialist, 2009-2019

This paper examines questions about the safety and efficacy of psychotropic medication, and looks at how these questions should impact the field of counseling. The paper first looks at increasing rates of use of psychotropic medication, and establishes that nearly every clinical mental health counselor will work with clients who are taking or considering taking such medication. The paper next examines the scientific literature and establishes that there is a legitimate basis for questions to be raised about the safety and efficacy of these medications. The paper goes on to establish that there is a foundation in ethical codes and …

Effects Of Repeated Quetiapine Treatment On Conditioned Avoidance Responding In Rats, Jun Gao, Min Feng, Natashia Swalve, Collin Davis, Nan Sui, Ming Li

Department of Psychology: Faculty Publications

The present study characterized the behavioral mechanisms of avoidance–disruptive effect of quetiapine in the conditioned avoidance response test under two behavioral testing (2 warning signals vs. 1 warning signal) and two drug administration conditions (subcutaneous vs. intravenous). In Experiments 1 and 2, well-trained adult male Sprague-Dawley rats were tested under the subcutaneous (s.c.) quetiapine treatment (5.0, 15.0, 25.0, 50.0 mg/kg) for 7 days in a novel procedure consisting of two conditioned stimuli (CS) (white noise serving as CS1 and pure tone as CS2). Only the highest dose (50.0 mg/kg) produced a persistent suppression of the avoidance response without impairing the …

Predicting Human Drug Toxicity And Safety Via Animal Tests: Can Any One Species Predict Drug Toxicity In Any Other, And Do Monkeys Help?, Jarrod Bailey, Michelle Thew, Michael Balls

Laboratory Experiments Collection

Animals are still widely used in drug development and safety tests, despite evidence for their lack of predictive value. In this regard, we recently showed, by producing Likelihood Ratios (LRs) for an extensive data set of over 3,000 drugs with both animal and human data, that the absence of toxicity in animals provides little or virtually no evidential weight that adverse drug reactions will also be absent in humans. While our analyses suggest that the presence of toxicity in one species may sometimes add evidential weight for risk of toxicity in another, the LRs are extremely inconsistent, varying substantially for …

Evaluating The Impact Of Pharmacist Health Education On The Perceptions Of The Pharmacist’S Role Among Women Living In A Homeless Shelter, Laura V. Tsu, Kelsey Buckley, Sarah Nguyen, Jennifer Kohn

Pharmacy Faculty Articles and Research

Objectives: To determine the impact of pharmacist-provided educational seminars on the participant’s perception of the pharmacist’s role in providing women’s health education. Secondary objectives include the participant’s level of perceived benefit from the information provided during each presentation, as well as determining characteristics of participants who are interested in attending seminars.

Methods: This is a prospective study conducted within a homeless women’s shelter in Phoenix, Arizona. Pharmacists and pharmacy students provided 10 monthly educational seminars on topics related to women’s health. Participants completed a pre- and post-seminar survey regarding their perceptions of the presentations and pharmacists.

Results: …

The Flaws And Human Harms Of Animal Experimentation, Aysha Akhtar

Experimentation Collection

Nonhuman animal (“animal”) experimentation is typically defended by arguments that it is reliable, that animals provide sufficiently good models of human biology and diseases to yield relevant information, and that, consequently, its use provides major human health benefits. I demonstrate that a growing body of scientific literature critically assessing the validity of animal experimentation generally (and animal modeling specifically) raises important concerns about its reliability and predictive value for human outcomes and for understanding human physiology. The unreliability of animal experimentation across a wide range of areas undermines scientific arguments in favor of the practice. Additionally, I show how animal …

Magic Bullet, Karen Haydock

The STEAM Journal

Two of the most powerful types of corporations in the world today are those that produce pharmaceuticals and weapons. While the corporations are concerned with increasing their profits, we wonder if their products have any magical powers.

[India ink on rag paper]

This poster explores the military-industrial complex. The weapons industry profits through imperialism. The pharmaceutical industry profits through by taking advantage of people’s illnesses.

The poster has multiple interpretations, hopefully encouraging the viewer to participate by asking relevant questions, such as:

“What is that person drinking?”

”Are they pills or bombs?”

“Medicines cure us - how can a pill …

The Efficacy Of Three Types Of Analgesic Drugs In Reducing Pain In The Rainbow Trout, Oncorhynchus Mykiss, Jessica J. Mettam, Lois J. Oulton, Catherine R. Mccrohan, Lynne U. Sneddon

Lynne Sneddon, PhD

Recent research has shown the possibility of pain perception in fish; therefore, the use of analgesia or “painkillers” should be considered for invasive procedures. However, there is relatively little information on the effectiveness of analgesic drugs nor on the appropriate dose for fish. This study assessed the efficacy of three types of drug: an opioid, buprenorphine, a non-steroidal anti-inflammatory drug (NSAID), carprofen and a local anaesthetic, lidocaine. Each drug was tested at three doses on rainbow trout that were noxiously stimulated and the most effective dose was also given to fish experiencing no pain to investigate side-effects. Ventilation rate and …

Behavioral And Pharmacological Investigation Of Anxiety And Maternal Responsiveness Of Postpartum Female Rats In A Pup Elevated Plus Maze, Yu Yang, Jingxue Qin, Weihai Chen, Hong Chen, Ming Li

Department of Psychology: Faculty Publications

The present study investigated the validity of a novel pup-based repeated elevated plus maze task to detect reduced anxiety and increased maternal responsiveness in postpartum female rats and explored the roles of dopamine D2, serotonin transporter and GABA/benzodiazepine receptors in the mediation of these processes. Sprague–Dawley postpartum or nulliparous female rats were tested 4 times every other day on postpartum days 4, 6 and 8 in an elevated plus maze with 4 pups or 4 pup-size erasers placed on each end of the two open arms. When tested with erasers, untreated postpartum mother rats entered the open arms proportionally more …

Commencement Program 2015, Loma Linda University

Commencement Programs

CONTENTS

1 | Message from the President

3 | 2015 Events of Commencement

5 | The Academic Procession

7 | Significance of Academic Regalia

9 | The Good Samaritan

10 | University History Highlights

12 | Loma Linda University Song - "Healing Love"

13 | The Speakers

23 | The University Honorees

45 | The School Honorees

72 | The Programs

• School of Medicine, 73
• School of Pharmacy, 95
• School of Dentistry, 103
• School of Allied Health Professions, 122
• School of Allied Health Professions - Physical Therapy, 143
• School of Public Health, 154
• School of Behavioral Health and School of …

Review Of Edison Bicudo, Pharmaceutical Research, Democracy And Conspiracy: International Clinical Trials In Local Medical Institutions, Roberto Abadie

Department of Sociology: Faculty Publications

The pharmaceutical industry is—along with the financial and weapons industries—one of the most globalized and profitable business domains. But they wouldn’t make any profits if they weren’t able to recruit research subjects to test an increasing number of drugs. This global trial economy creates its own assemblages of clinical trials, often run by hired contract research organizations (CROs), who fight among each other in a rat-race competition, promising quick and effective trials; at the same time, enterprising countries, hospitals, and doctors jump on the drug trial economy bandwagon by promising quick, endless access to a large pool of research subjects, …

Critical Analysis Of The Confounding Of Clinical Trials, Eleanor L. Jordan

Senior Honors Projects, 2010-2019

To provide a comprehensive overview of issues confounding clinical trials, Chapter 2 will discuss the parties involved in the research and development of medications and detail the individual responsibilities of each. However, the ambition of these individual entities often produces a conflict of interest especially when profits are involved [9]. Organizations and individuals such as insurance corporations, pharmaceutical companies (sponsors), pharmacy benefit managers, investigators (doctors/medical professionals) and most importantly patients, are all involved in carrying out clinical research and have definitive responsibilities they are required to follow for unbiased results. However, many rules are overlooked and biases go unrecorded causing …

Improving Healthcare Outcomes Through An Interdisciplinary Effort Of Social Work And Pharmacy In A “Village” Model Setting, Elizabeth Hipp, Lauren Post

Ohio Association of Gerontology and Education Conference

No abstract provided.

Swosu Research And Scholarly Activity Fair 2015, Jason L. Johnson

SWOSU Research and Scholarly Activity Fair Programs

Welcome to the Twenty-Second SWOSU Research and Scholarly Activity Fair! On display today are 103 presentations involving 169 student researchers, writers, performers, and artists, and 40 faculty sponsors encompassing scholarly activity from the Departments of: Accounting, Computer Science, and Entrepreneurship; Art, Communication, and Theatre; Biological Sciences; Chemistry and Physics; Education; Engineering Technology; Finance, Management, and Marketing; Language and Literature; Music; Nursing and Allied Health; Pharmaceutical Sciences; Psychology; and Social Sciences.

2015 Symposium Overview, Cedarville University

The Research and Scholarship Symposium (2013-2019)

Click the "Download" button in the top right corner to view the abstract booklet.

Community Education On Mtm Services, Jacob M. Davis, Kristin Lessig, Lindsay M. Mailloux, Samantha A. Smolinski, Stephen K. Yeboah, Aleda M.H. Chen, Ginger D. Cameron, Thaddeus T. Franz, Jenna G. Lawhead

The Research and Scholarship Symposium (2013-2019)

Background: Medication nonadherence, defined as “the number of doses not taken or taken incorrectly that jeopardizes the patient’s therapeutic outcome,” is a major health problem with about 43% of the general population nonadherent to their medications. Medication nonadherence accounts for an estimated 125,000 deaths per year in the US, 33-69% of medication-related hospital readmissions, and an estimated $100 to $300 billion in direct and indirect medical costs. Medication therapy management (MTM), defined as “a distinct service or group of services that optimize therapeutic outcomes for individual patients,” has been found to reduce medication nonadherence. However, many individuals eligible for MTM …

Simulation-Based Interdisciplinary Team Learning—Pilot Study, Brian C. Patterson, Adam H. Altman, Brittani H. Purkeypile, Bethany Sibbitt, Zachary Ilgiovine, Nicholaus Christian, Phillip J. Wenzell, Natasha Mehta, Raymond Ten Eyck

The Research and Scholarship Symposium (2013-2019)

Background: Currently, interprofessional education (IPE) is becoming widely integrated into healthcare professional education with regulating bodies including IPE as a curricular requirement. Although recent studies have concluded that students value IPE, there are a number of challenges associated with initial engagement. Many schools are unsure how to approach this interdisciplinary integration. In addition to IPE, simulation has become an important tool in the education of health professionals. As the first exercise at Wright State University involving interprofessional groups composed completely of undergraduates, interested students from the Boonshoft School of Medicine, the WSU College of Nursing and Health, and the Cedarville …

The Use Of Pbl In An Interprofessional Education Course For Health Care Professional Students, Kristine M. L'Ecuyer, David Pole, Sheila A. Leander

Interdisciplinary Journal of Problem-Based Learning

A problem-based learning (PBL) framework was utilized in a series of six interprofessional team seminars (IPTS) for postbaccalaureate students from seven health professions. The goal of IPTS was to develop a collaborative practice-ready workforce prepared to respond to patient care needs through use of concrete examples, skills development, critical thinking, and problem solving in safe, faculty-facilitated small groups. The collaborative nature of PBL closely correlates with teaching methodologies of the IPTS series. This study analyzed critical reflection assignments of nursing students in accelerated programs to determine the effectiveness of IPTS at preparing students for interprofessional collaborative practice. Findings indicated that …

Representatives Perales, Hackett Participate In Healthcare Forum, Mark D. Weinstein

News Releases

Cedarville University School of Pharmacy will host a policy forum on healthcare legislation with State Representatives Rick Perales and Bob Hackett along with Antonio Ciaccia, director of government and public affairs from the Ohio Pharmacist Association. The event, open to the public, will be held on Thursday, Feb. 5, in the Health Sciences Center in Room 107 beginning at 5:30 p.m.

This event will allow students to interact with representatives on legislative issues related to pharmacy. Currently the topics set in place for the forum are: student involvement, advocacy and communication with legislators, health care reform, Provider Status for pharmacists, …

Survey Evaluation Of Pharmacy Practice Involving Deaf Patients, Mckenzie C. Ferguson, Leah M. Shan

Pharmacy Faculty Research, Scholarship, and Creative Activity

For a patient that is deaf, providing patient care can be more difficult due to communication barriers. This study was conducted in order to better understand pharmacists’ current means of communicating with deaf patients as well as investigating pharmacists’ knowledge of their legal responsibility to these patients.

Methods

Surveys were used to gather information from pharmacists and were distributed in areas with a large population of deaf patients.

Context And Contribution: Going Beyond The Research Paper In The Health Sciences, Laura Menard

Scholarship and Professional Work

Conference poster presented at the Midwest Medical Library Association Chapter Meeting, October 2-6, 2015 in Louisville, KY.