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Behavioral And Histological Effects Of Traumatic Brain Injury On Alzheimer's Disease Transgenic Mice, Sara Leilani Kellogg
Behavioral And Histological Effects Of Traumatic Brain Injury On Alzheimer's Disease Transgenic Mice, Sara Leilani Kellogg
USF Tampa Graduate Theses and Dissertations
The main objective of this study was to elucidate the possible mechanistic link between traumatic brain injury (TBI) and Alzheimer's disease (AD) using an animal model. We examined behavioral and histological effects of TBI in pre-symptomatic AD-transgenic mice (C57B6/SJL/SwissWebster/B6D2F1). In previous studies, these mice displayed AD-like behavioral deficits by 15-17 months of age and AD-like neuropathology as early as six months of age. To clarify the effects of TBI on these mice, the present study began when they were about three months of age and the study ended when they were about five months of age. As a control, non-transgenic …