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Articles 1 - 5 of 5
Full-Text Articles in Social and Behavioral Sciences
Differential Modification Of Cortical And Thalamic Projections To Cat Primary Auditory Cortex Following Early- And Late-Onset Deafness., Nicole Chabot, Blake E Butler, Stephen G Lomber
Differential Modification Of Cortical And Thalamic Projections To Cat Primary Auditory Cortex Following Early- And Late-Onset Deafness., Nicole Chabot, Blake E Butler, Stephen G Lomber
Brain and Mind Institute Researchers' Publications
Following sensory deprivation, primary somatosensory and visual cortices undergo crossmodal plasticity, which subserves the remaining modalities. However, controversy remains regarding the neuroplastic potential of primary auditory cortex (A1). To examine this, we identified cortical and thalamic projections to A1 in hearing cats and those with early- and late-onset deafness. Following early deafness, inputs from second auditory cortex (A2) are amplified, whereas the number originating in the dorsal zone (DZ) decreases. In addition, inputs from the dorsal medial geniculate nucleus (dMGN) increase, whereas those from the ventral division (vMGN) are reduced. In late-deaf cats, projections from the anterior auditory field (AAF) …
L’Animal : Agent Du Biopouvoir Dans L’Imaginaire Postcolonial Alain Cyr Pangop Kameni Et Hervé Tchumkam, Alain Cyr Pangop Kameni, Hervé Tchumkam
L’Animal : Agent Du Biopouvoir Dans L’Imaginaire Postcolonial Alain Cyr Pangop Kameni Et Hervé Tchumkam, Alain Cyr Pangop Kameni, Hervé Tchumkam
Présence Francophone: Revue internationale de langue et de littérature
This article seeks to understand the status of the animal and its relation to biopolitics in postcolonial fiction. Going beyond and against Graham Huggan’s notion of “postcolonial exotic”, the analysis of the relation between human and animal is twofold: first, describe and interpret the mechanisms of power, and second, show how the figure of the beast which is at the center of political struggle and social conflict makes more complex the understanding of the “discipline and punish” in postcolonial contexts. Ultimately, drawing on the study of selected novels and drama, the aim of this paper is to show that the …
Closed Head Injury In An Age-Related Alzheimer Mouse Model Leads To An Altered Neuroinflammatory Response And Persistent Cognitive Impairment, Scott J. Webster, Linda J. Van Eldik, D. Martin Watterson, Adam D. Bachstetter
Closed Head Injury In An Age-Related Alzheimer Mouse Model Leads To An Altered Neuroinflammatory Response And Persistent Cognitive Impairment, Scott J. Webster, Linda J. Van Eldik, D. Martin Watterson, Adam D. Bachstetter
Sanders-Brown Center on Aging Faculty Publications
Epidemiological studies have associated increased risk of Alzheimer's disease (AD)-related clinical symptoms with a medical history of head injury. Currently, little is known about pathophysiology mechanisms linked to this association. Persistent neuroinflammation is one outcome observed in patients after a single head injury. Neuroinflammation is also present early in relevant brain regions during AD pathology progression. In addition, previous mechanistic studies in animal models link neuroinflammation as a contributor to neuropathology and cognitive impairment in traumatic brain injury (TBI) or AD-related models. Therefore, we explored the potential interplay of neuroinflammatory responses in TBI and AD by analysis of the temporal …
Animal Cognition, Kristin Andrews, Ljiljana Radenovic
Animal Cognition, Kristin Andrews, Ljiljana Radenovic
Kristin Andrews, PhD
Debates in applied ethics about the proper treatment of animals often refer to empirical data about animal cognition, emotion, and behavior. In addition, there is increasing interest in the question of whether any nonhuman animal could be something like a moral agent.
Prolonged In Vivo Retention Of A Cathepsin D Targeted Optical Contrast Agent In A Mouse Model Of Alzheimer's Disease., Jonatan A Snir, Mojmir Suchy, Keith St Lawrence, Robert H E Hudson, Stephen H Pasternak, Robert Bartha
Prolonged In Vivo Retention Of A Cathepsin D Targeted Optical Contrast Agent In A Mouse Model Of Alzheimer's Disease., Jonatan A Snir, Mojmir Suchy, Keith St Lawrence, Robert H E Hudson, Stephen H Pasternak, Robert Bartha
Brain and Mind Institute Researchers' Publications
BACKGROUND: Cathepsin D (CatD) is a lysosomal protease that is elevated early in Alzheimer's disease (AD). We have previously developed a Targeted contrast agent (CA) to detect CatD activity in vivo, consisting of a magnetic resonance imaging/fluorescent moiety linked to a cell penetrating peptide (CPP) by means of a CatD cleavage site and have demonstrated its uptake in the brain of an AD mouse model.
OBJECTIVE: The purpose of this study was to characterize the in vivo retention of a near infra-red fluorescent dye labeled version of this CA.
METHODS: Six adult C57Bl/6 wild-type mice and six adult 5XFAD transgenic …