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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
Modified Single Prolonged Stress Reduces Cocaine Self-Administration During Acquisition Regardless Of Rearing Environment, Rebecca S. Hofford, Mark A. Prendergast, Michael T. Bardo
Modified Single Prolonged Stress Reduces Cocaine Self-Administration During Acquisition Regardless Of Rearing Environment, Rebecca S. Hofford, Mark A. Prendergast, Michael T. Bardo
Psychology Faculty Publications
Until recently, there were few rodent models available to study the interaction of post-traumatic stress disorder (PTSD) and drug taking. Like PTSD, single prolonged stress (SPS) produces hypothalamic-pituitary-adrenal (HPA) axis dysfunction and alters psychostimulant self-administration. Other stressors, such as isolation stress, also alter psychostimulant self-administration. However, it is currently unknown if isolation housing combined with SPS can alter the acquisition or maintenance of cocaine self-administration. The current study applied modified SPS (modSPS; two hours restraint immediately followed by cold swim stress) to rats raised in an isolation condition (Iso), enrichment condition (Enr), or standard condition (Std) to measure changes in …
Neural Responses To Peer Rejection In Anxious Adolescents: Contributions From The Amygdala-Hippocampal Complex, Jennifer Y.F. Lau, Amanda E. Guyer, Erin Tone, Jessica Jenness, Jessica M. Parrish, Daniel S. Pine, Eric E. Nelson
Neural Responses To Peer Rejection In Anxious Adolescents: Contributions From The Amygdala-Hippocampal Complex, Jennifer Y.F. Lau, Amanda E. Guyer, Erin Tone, Jessica Jenness, Jessica M. Parrish, Daniel S. Pine, Eric E. Nelson
Psychology Faculty Publications
Peer rejection powerfully predicts adolescent anxiety. While cognitive differences influence anxious responses to social feedback, little is known about neural contributions. Twelve anxious and 12 age-, gender- and IQ-matched, psychiatrically-healthy adolescents received ‘not interested’ and ‘interested’ feedback from unknown peers during a Chatroom task administered in a neuroimaging scanner. No group differences emerged in subjective ratings to peer feedback, but all participants reported more negative emotion at being rejected (than accepted) by peers to whom they had assigned high desirability ratings. Further highlighting the salience of such feedback, all adolescents, independent of anxiety levels, manifested elevated responses in the amygdala-hippocampal …