Social and Behavioral Sciences Commons^™

An Integrated Relational Framework Of Depressed Mood And Anhedonia During Pregnancy, Rebecca L. Brock, Molly Franz, Erin L. Ramsdell

Department of Psychology: Faculty Publications

Objective: The aim of the present study was to test a unified framework that integrates several theories into a cohesive model to explain the interplay between neuroticism and intimate relationship quality as risk factors for prenatal depression.

Background: There is a notable spike in risk for depression during pregnancy, and the processes unfolding in the interparental relationship during this important time in the family life cycle might serve to mitigate or enhance this risk. Yet there is a need for theory-driven research integrating multiple conceptual frameworks to explicate the role of intimate relationship quality in depression.

Method: In a sample …

Drug–Drug Conditioning Between Citalopram And Haloperidol Or Olanzapine In A Conditioned Avoidance Response Model: Implications For Polypharmacy In Schizophrenia, Nathan L. Sparkman, Ming Li

Department of Psychology: Faculty Publications

Patients with schizophrenia often have anxiety and depression, and thus are treated with multiple psychotherapeutic medications. This practice of polypharmacy increases the possibility for drug–drug interactions. However, the pharmacological and behavioral mechanisms underlying drug–drug interactions in schizophrenia remain poorly understood. In the present study, we adopted a preclinical approach and examined a less known behavioral mechanism, drug–drug conditioning (DDC) between haloperidol (a typical antipsychotic) or olanzapine (atypical antipsychotic) and citalopram (a selective serotonin reuptake inhibitor). A rat two-way conditioned avoidance response paradigm was used to measure antipsychotic activity and determine how DDC may alter the antipsychotic efficacy in this model. …