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Full-Text Articles in Social and Behavioral Sciences
Prospective Studies Of Cardiovascular Risk Factors And Mild Cognitive Impairment, Kevin Sullivan
Prospective Studies Of Cardiovascular Risk Factors And Mild Cognitive Impairment, Kevin Sullivan
Electronic Theses and Dissertations
The association of cardiovascular risk factors including hypertension, diabetes, cholesterol, kidney function, and arterial stiffness with cognitive impairment in older adults is a well-studied phenomenon. However, there is considerably less evidence relating cardiovascular health specifically to a diagnosis of Mild Cognitive Impairment (MCI). As a precursor state of dementia, MCI is characterized by a decline in cognitive function from previous level, but not to the degree that activities of daily living are impaired. Not everyone who is diagnosed with MCI will eventually transition to dementia, but the transition rates are much higher compared to the general population (5-15% per year …
Arterial Pulse Wave Velocity And Cognition With Advancing Age, Merrill F. Elias, Michael A. Robbins, Marc M. Budge, Walter P. Abhayaratna, Gregory A. Dore, Penelope K. Elias
Arterial Pulse Wave Velocity And Cognition With Advancing Age, Merrill F. Elias, Michael A. Robbins, Marc M. Budge, Walter P. Abhayaratna, Gregory A. Dore, Penelope K. Elias
Maine-Syracuse Longitudinal Papers
We hypothesized that carotid-femoral pulse wave velocity (PWV), a marker of arterial stiffness, interacts with age such that the magnitude of associations between PWV and cognitive performance are greater with increasing age and that this interaction is observed despite adjustments for demographic variables, mean arterial pressure, and cardiovascular risk factors. PWV was estimated using applanation tonometry in 409 dementia- and stroke-free participants of the Maine-Syracuse Longitudinal Study (24 to 92 years of age; 62.3% women). Using linear regression analyses in a cross-sectional design, associations between PWV and age and the interaction of PWV and age were examined in relation to …
Serum Cholesterol And Cognitive Performance In The Framingham Heart Study, Penelope K. Elias, Merrill F. Elias, Ralph B. D'Agostino, Lisa M. Sullivan, Philip A. Wolf
Serum Cholesterol And Cognitive Performance In The Framingham Heart Study, Penelope K. Elias, Merrill F. Elias, Ralph B. D'Agostino, Lisa M. Sullivan, Philip A. Wolf
Maine-Syracuse Longitudinal Papers
Objective: The objective of this study was to examine the relationship between total cholesterol (TC) and cognitive performance within the context of the Framingham Heart Study, a large, community-based, prospective investigation of cardiovascular risk factors. Methods: Participants were 789 men and 1105 women from the Framingham Heart Study original cohort who were free of dementia and stroke and who received biennial TC determinations over a 16- to 18-year surveillance period. Cognitive tests were administered 4 to 6 years subsequent to the surveillance period and consisted of measures of learning, memory, attention/ concentration, abstract reasoning, concept formation, and organizational abilities. Statistical …