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Full-Text Articles in Social and Behavioral Sciences
Novel Olanzapine Analogues Presenting A Reduced H1 Receptor Affinity And Retained 5ht2a/D2 Binding Affinity Ratio, Somayeh Jafari, Marc E. Bouillon, Xu-Feng Huang, Stephen G. Pyne, Francesca Fernandez-Enright
Novel Olanzapine Analogues Presenting A Reduced H1 Receptor Affinity And Retained 5ht2a/D2 Binding Affinity Ratio, Somayeh Jafari, Marc E. Bouillon, Xu-Feng Huang, Stephen G. Pyne, Francesca Fernandez-Enright
Xu-Feng Huang
Background Olanzapine is an atypical antipsychotic drug with high clinical efficacy, but which can cause severe weight gain and metabolic disorders in treated patients. Blockade of the histamine 1 (H1) receptors is believed to play a crucial role in olanzapine induced weight gain, whereas the therapeutic effects of this drug are mainly attributed to its favourable serotoninergic 2A and dopamine 2 (5HT2A/D2) receptor binding affinity ratios. Results We have synthesized novel olanzapine analogues 8a and 8b together with the already known derivative 8c and we have examined their respective in vitro affinities for the 5HT2A, D2, and H1 receptors. Conclusions …
Histamine H1 Receptor Agonist And Control Of Olanzapine-Induced Obesity, Jiamei Lian, Xu-Feng Huang, N Pai, C Deng
Histamine H1 Receptor Agonist And Control Of Olanzapine-Induced Obesity, Jiamei Lian, Xu-Feng Huang, N Pai, C Deng
Xu-Feng Huang
No abstract provided.
The Effects Of Antipsychotics On The Density Of Cannabinoid Receptors In The Dorsal Vagal Complex Of Rats: Implications For Olanzapine-Induced Weight Gain, Katrina Weston-Green, Xu-Feng Huang, Mei Han, Chao Deng
The Effects Of Antipsychotics On The Density Of Cannabinoid Receptors In The Dorsal Vagal Complex Of Rats: Implications For Olanzapine-Induced Weight Gain, Katrina Weston-Green, Xu-Feng Huang, Mei Han, Chao Deng
Xu-Feng Huang
Some atypical antipsychotics clinically used to treat schizophrenia induce weight gain by unknown mechanisms. The dorsal vagal complex (DVC) of the brainstem and the endogenous cannabinoid system are implicated in the regulation of appetite signalling and food intake. We investigated whether antipsychotic drugs alter cannabinoid receptor-binding density in the DVC. Female Sprague–Dawley rats were treated with olanzapine, haloperidol, aripiprazole or vehicle for 1 wk (short-term) or 12 wk (chronic). Quantitative autoradiographic methods were employed to investigate the binding density of cannabinoid receptors in the DVC using a highly sensitive Beta Imager. Short-term olanzapine induced a significant 39% decrease in cannabinoid …