Open Access. Powered by Scholars. Published by Universities.®
Social and Behavioral Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Social and Behavioral Sciences
Dietary Fats And Membrane Function: Implications For Metabolism And Disease, Anthony J. Hulbert, Nigel Turner, Leonard H. Storlein, Paul Else
Dietary Fats And Membrane Function: Implications For Metabolism And Disease, Anthony J. Hulbert, Nigel Turner, Leonard H. Storlein, Paul Else
Faculty of Health and Behavioural Sciences - Papers (Archive)
Lipids play varied and critical roles in metabolism, with function dramatically modulated by the individual fatty acid moities in complex lipid entities. In particular, the fatty acid composition of membrane lipids greatly influences membrane function. Here we consider the role of dietary fatty acid profile on membrane composition and, in turn, its impact on prevalent disease clusters of the metabolic syndrome and mental illness. Applying the classical physiological conformer-regulator paradigm to quantify the influence of dietary fats on membrane lipid composition (i.e. where the membrane variable is plotted against the same variable in the environment - in this case dietary …
Systemic Levels Of Interleukin-6 And Matrix Metalloproteinase-9 In Patients With Multiple Myeloma May Be Useful As Prognostic Indexes Of Bone Disease, Aikaterini Sfiridaki, Spyridon Miyakis, George Tsirakis, Athanasios Alegakis, Andreas M. Passam, Ermioni Kandidaki, Andrerw N. Margioris, Michael Alexandrakis
Systemic Levels Of Interleukin-6 And Matrix Metalloproteinase-9 In Patients With Multiple Myeloma May Be Useful As Prognostic Indexes Of Bone Disease, Aikaterini Sfiridaki, Spyridon Miyakis, George Tsirakis, Athanasios Alegakis, Andreas M. Passam, Ermioni Kandidaki, Andrerw N. Margioris, Michael Alexandrakis
Faculty of Science, Medicine and Health - Papers: part A
Multiple myeloma is characterized by accelerated production of the proteolytic enzyme matrix metalloproteinase (MMP)-9. We hypothesized that myeloma- produced MMP-9 may influence the rate of bone turnover in a paracrine manner. Thus, we examined the correlations of MMP-9 levels, disease severity, and bone turnover rate as evaluated by markers of bone formation and resorption. Thirty-seven newly diagnosed multiple myeloma patients (nine of Durie-Salmon stage I, 12 of stage II and 16 of stage III) and 12 age-matched controls were studied. Serum MMP-9 levels were significantly higher at stage II compared to stage I (188.78"91.27 vs. 59.25"33.09 ng/mL, p-0.004). Additionally, free …