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Articles 1 - 6 of 6

Full-Text Articles in Social and Behavioral Sciences

Polygenic Hazard Scores In Preclinical Alzheimer's Disease, Chin Hong Tan, Bradley T. Hyman, Jacinth J. X. Tan, Christopher P. Hess, William P. Dillon, Gerard D. Schellenberg, Lilah M. Besser, Walter A. Kukull, Karolina Kauppi, Linda K. Mcevoy, Ole A. Andreassen, Anders M. Dale, Chun Chieh Fan, Rahul S. Desikan Sep 2017

Polygenic Hazard Scores In Preclinical Alzheimer's Disease, Chin Hong Tan, Bradley T. Hyman, Jacinth J. X. Tan, Christopher P. Hess, William P. Dillon, Gerard D. Schellenberg, Lilah M. Besser, Walter A. Kukull, Karolina Kauppi, Linda K. Mcevoy, Ole A. Andreassen, Anders M. Dale, Chun Chieh Fan, Rahul S. Desikan

Research Collection School of Social Sciences

Identifying asymptomatic older individuals at elevated risk for developing Alzheimer's disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE e4 carrier status. Older individuals in the highest PHS percentiles showed the highest AD incidence rates. PHS predicted longitudinal clinical decline among older individuals with moderate to high CERAD (amyloid) and Braak (tau) scores at autopsy, even among APOE e4 non-carriers. Beyond APOE, PHS may help identify asymptomatic individuals at highest risk for developing Alzheimer's neurodegeneration.


Unobtrusive Monitoring To Detect Depression For Elderly With Chronic Illnesses, Jung-Yoon Kim, Na Liu, Hwee Xian Tan, Chao-Hsien Chu Sep 2017

Unobtrusive Monitoring To Detect Depression For Elderly With Chronic Illnesses, Jung-Yoon Kim, Na Liu, Hwee Xian Tan, Chao-Hsien Chu

Research Collection School Of Computing and Information Systems

Mental health related disorders are common diseases, especially among the elder. Among the various mental health diseases, one potential threat to ageing-in-place is the risk of depression. In this paper, we propose a simple unobtrusive sensing system using passive infra-red motion sensors to monitor the activities of daily living of elderly, who are living alone. A feature extraction module comprising of three layers-states, events, and activities, and the corresponding algorithms are proposed to extract features. Four popular classification models-neural network, C4.5 decision tree, Bayesian network, and support vector machine are then applied to detect the severity of depression. We implement …


Ultrasonography In Acupuncture: Uses In Education And Research, Mabel Qi He Leow, Shu Li Cui, Mohammad Taufik Bin Mohamed Shah, Taige Cao, Shian Chao Tay, Peter Kay Chai Tay, Chin Chin Ooi Jun 2017

Ultrasonography In Acupuncture: Uses In Education And Research, Mabel Qi He Leow, Shu Li Cui, Mohammad Taufik Bin Mohamed Shah, Taige Cao, Shian Chao Tay, Peter Kay Chai Tay, Chin Chin Ooi

Research Collection School of Social Sciences

This study aims to explore the potential use of ultrasound in locating the second posterior sacral foramen acupuncture point, quantifying depth of insertion and describing surrounding anatomical structures. We performed acupuncture needle insertion on a study team member. There were four steps in our experiment. First, the acupuncturist located the acupuncture point by palpation. Second, we used an ultrasound machine to visualize the structures surrounding the location of the acupuncture point and measure the depth required for needle insertion. Third, the acupuncturist inserted the acupuncture needle into the acupuncture point at an angle of 30°. Fourth, we performed another ultrasound …


Towards Unobtrusive Mental Well-Being Monitoring For Independent-Living Elderly, Sinh Huynh, Hwee-Pink Tan, Youngki Lee Jun 2017

Towards Unobtrusive Mental Well-Being Monitoring For Independent-Living Elderly, Sinh Huynh, Hwee-Pink Tan, Youngki Lee

Research Collection School Of Computing and Information Systems

It is essential to proactively detect mental health problems such as loneliness and depression in the independently-living elderly for timely intervention by caregivers. In this paper, we introduce an unobtrusive sensor-enabled monitoring system that has been deployed to 50 government housing ats with the independent-living elderly for two years. Then, we also present our initial findings from the 6-month sensor data between August 2015 and April 2016 as well as the survey data to measure the subjective well-being indicator. Our study showed the promising results that "room-level movements within a house" and "going out" behavior captured by our simple sensor …


Joint Spatial Time Series Epidemiological Analysis Of Malaria And Cutaneous Leishmaniasis Infection, O. A. Adegboye, M. Al-Saghir, Denis H. Y. Leung Mar 2017

Joint Spatial Time Series Epidemiological Analysis Of Malaria And Cutaneous Leishmaniasis Infection, O. A. Adegboye, M. Al-Saghir, Denis H. Y. Leung

Research Collection School Of Economics

Malaria and leishmaniasis are among the two most important health problems of many developing countries especially in the Middle East and North Africa. It is common for vector-borne infectious diseases to have similar hotspots which may be attributed to the overlapping ecological distribution of the vector. Hotspot analyses were conducted to simultaneously detect the location of local hotspots and test their statistical significance. Spatial scan statistics were used to detect and test hotspots of malaria and cutaneous leishmaniasis (CL) in Afghanistan in 2009. A multivariate negative binomial model was used to simultaneously assess the effects of environmental variables on malaria …


Lay Health Epistemics And Motivated Information Behaviors Of New Food Technology, Soojin Kim, Jeong-Nam Kim, Soo-Yun Kim Jan 2017

Lay Health Epistemics And Motivated Information Behaviors Of New Food Technology, Soojin Kim, Jeong-Nam Kim, Soo-Yun Kim

Research Collection Lee Kong Chian School Of Business

This study examines relationships among health information orientation, situational perceptual frames, and active information behaviors pertinent to the safety controversy of genetically-modified (GM) food technology. A web survey was conducted in the US (N = 393). Based on our findings, an integrative model of Kim and Grunig’s (2011) Situational Theory of Problem Solving (STOPS) and Dutta-Bergman’s (2004) concept of health information orientation is suggested to explain lay health epistemics and various information behaviors about that new food technology. The study’s theoretical and practical implications are discussed.