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Full-Text Articles in Social and Behavioral Sciences
Alterations To Melanocortinergic, Gabaergic And Cannabinoid Neurotransmission Associated With Olanzapine-Induced Weight Gain, Katrina Weston-Green, Xu-Feng Huang, Chao Deng
Alterations To Melanocortinergic, Gabaergic And Cannabinoid Neurotransmission Associated With Olanzapine-Induced Weight Gain, Katrina Weston-Green, Xu-Feng Huang, Chao Deng
Xu-Feng Huang
Background/Aim: Second generation antipsychotics (SGAs) are used to treat schizophrenia but can cause serious metabolic side-effects, such as obesity and diabetes. This study examined the effects of low to high doses of olanzapine on appetite/ metabolic regulatory signals in the hypothalamus and brainstem to elucidate the mechanisms underlying olanzapineinduced obesity. Methodology/Results: Levels of pro-opiomelanocortin (POMC), neuropeptide Y (NPY) and glutamic acid decarboxylase (GAD65, enzyme for GABA synthesis) mRNA expression, and cannabinoid CB1 receptor (CB1R) binding density (using [3H]SR- 141716A) were examined in the arcuate nucleus (Arc) and dorsal vagal complex (DVC) of female Sprague Dawley rats following 0.25, 0.5, 1.0 …