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Lessons From Sicilian Centenarians For Anti-Ageing Medicine. The Oxi-Inflammatory Status, Calogero Caruso, Giulia Accardi, Anna Aiello, Anna Calabrò, Mattia Emanuela Ligotti, Giuseppina Candore

Translational Medicine @ UniSa

Population ageing is a great achievement of humanity, but it also represents a challenge that the Western world is currently facing, as ageing is associated with increased susceptibility to age-related inflammatory diseases. Therefore, it is necessary to fully understand the mechanisms of healthy ageing to prevent the harmful aspects of ageing. The study of long living ndividuals (LLIs) is a great model for trying to achieve this goal. Accordingly, the oxy-inflammatory status of Sicilian LLIs was reviewed in the present paper. Based on the reported data, anti-inflammatory and anti-oxidative stress strategies have been discussed, useful for delaying or avoiding the …

Kl-6 In Ards And Covid-19 Patients, Ornella Piazza, Giuliana Scarpati, Giovanni Boccia, Massimo Boffardi, Pasquale Pagliano

Translational Medicine @ UniSa

The Acute Respiratory Distress Syndrome (ARDS) is a common, devastating clinical pattern characterized by life-threatening respiratory failure. In ARDS there is an uncontrolled inflammatory response that results in alveolar damage, with the exudation of protein-rich pulmonary-edema fluid in the alveolar space. Although severe COVID-19 lung failure (CARDS) often meets diagnostic criteria of traditional ARDS, additional features have been reported, such as delayed onset, binary pulmonary compliant states, and hypercoagulable profile. Increased levels of Krebs von den Lungen 6 (KL-6, also known as MUC1) have been reported in both ARDS and CARDS. KL-6 is a transmembrane protein expressed on the apical …

Acute Coronary Syndrome In Patients With Sars-Cov-2 Infection: Pathophysiology And Translational Perspectives, Francesco Paolo Cancro, Michele Bellino, Luca Esposito, Stefano Romei, Mario Centore, Debora D’Elia, Mario Cristiano, Angelantonio Maglio, Albino Carrizzo, Barbara Rasile, Carmine Alfano, Carmine Vecchione, Gennaro Galasso

Translational Medicine @ UniSa

Acute coronary syndromes (ACS) may complicate the clinical course of patients with Coronavirus Disease 2019 (COVID-19). It is still unclear whether this condition is a direct consequence of the primary disease. However, several mechanisms including direct cellular damage, endothelial dysfunction, in-situ thrombosis, systemic inflammatory response, and oxygen supply-demand imbalance have been described in patients with COVID-19. The onset of a prothrombotic state may also be facilitated by the endothelial dysfunction secondary to the systemic inflammatory response and to the direct viral cell damage. Moreover, dysfunctional endothelial cells may enhance vasospasm and platelet aggregation. The combination of these factors promotes atherosclerotic …

Dpo: Diffuse Pulmonary Ossification - A Diagnostic Challenge, Gaetano Rea, Giuliana Giacobbe, Danila Caroppo, Silvia Iovine, Roberta Lieto, Marialuisa Bocchino, Tullio Valente, Angelantonio Maglio, Alessandro Vatrella

Translational Medicine @ UniSa

Diffuse pulmonary ossification (DPO) is a rare condition of DLD (diffuse lung disease) characterized by the presence of metaplastic ectopic bone in the lungs and is less frequent in patients without a clear background of lung diseases. DPO is characterized by very small calcific nodules, often with bone mature located in both lungs and often in peripheral areas of the lungs. Two patterns of DPO have been recognized dendriform and nodular. The dendriform type is less common and is characterized by a coral-like network of bone spiculae along the alveolar septa and is often related to interstitial fibrosis or chronic …

Globularia Alypum L. Modulates Inflammatory Markers In The Human Colon And Shows A Potential Antioxidant Role In Myeloid Leukemic Cells, Najla Hajji, Elodie Hudik, Paola Iovino, Nacim Zouari, Hichem Sebai, Oliver Nusse, Carolina Ciacci

Translational Medicine @ UniSa

Globularia alypum (GA), a plant of the Globulariacea family, has long been used as a traditional cure for inflammatory and metabolic illnesses.In addition to various in vitro model studies, the current work focuses on GA'santioxidant and anti-inflammatory properties in human colon biopsies.

Liquid Chromatography-Electrospray Ionization Mass Spectrometry identified the phenol components in GA aqueous extract (GAAE).The antioxidant ability of GAAE was tested in vitro utilizing chemiluminescence and flow cytometry using fluorescent yeastsn conjunction with PLB-985-human myeloid leukemia cells. Experiments on human colon biopsies after a biopsy challenge with Escherichia coli-lipopolysaccharides aimed tosee if GAAE had an anti-inflammatory impact on human …

The Time For A Consensus Regarding The Coeliac Disease Diagnosis In Adults Has Come: Balancing The Pros And Cons Of Omitting The Biopsy, Carolina Ciacci, Julio C. Bao

Translational Medicine @ UniSa

How balancing the pros and cons of omitting the biopsy in diagnosing CeD in adults?

Possible Association Of Telomere Length With Sleep Duration. A Preliminary Pilot Study In A Sicilian Cohort With Centenarians., Anna Aiello, Giulia Accardi, Sawan Alì, Calogero Caruso, Maxine Chen, Immaculata De Vivo, Mattia Emanuela Ligotti, Giovanni Scapagnini, Sergio Davinelli, Giuseppina Candore

Translational Medicine @ UniSa

Telomere length (TL) is considered a biomarker of ageing although this topic is still debated. Also, sleep pattern changes are physiological part of the normal ageing process. In fact, it is widely recognized that sleep duration declines with age, leading to dysregulation of circadian rhythms. The aim of our study was to analyse the possible association of sleep duration with TL in a sample of 135 subjects with ages ranging from 20 to 111 years, recruited from Palermo and neighbouring municipalities in Sicily (Italy). Preliminary data suggest that relative TL (RTL) decreases with age in both men and women. However, …

Role Of Bpifb4 In Immune System And Cardiovascular Disease: The Lesson From Centenarians, Francesco Montella, Valentina Lopardo, Monica Cattaneo, Albino Carrizzo, Carmine Vecchione, Elena Ciaglia, Annibale A. Puca

Translational Medicine @ UniSa

Recent discoveries have shed light on the participation of the immune system in the physio pathology of the cardiovascular system underpinning the importance of keeping the balance of the first to preserve the latter. Aging, along with other risk factors, can challenge such balance triggering the onset of cardiovascular diseases.

Among several mediators ensuring the proper cross-talk between the two systems, bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) has been shown to have a pivotal role, also by sustaining important signals such as eNOS and PKC-alpha.

In addition, the Longevity-associated variant (LAV), which is an haplotype allele in BPIFB4characterized by …