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Social and Behavioral Sciences Commons™
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Articles 1 - 4 of 4
Full-Text Articles in Social and Behavioral Sciences
Synthesis And Hydrolytic Evaluation Of Acid-Labile Imine-Linked Cytoxic Isatin Model Systems, Lidia Matesic, Julie Locke, Kara Perrow, Marie Ranson, John Bremner, Danielle Skropeta
Synthesis And Hydrolytic Evaluation Of Acid-Labile Imine-Linked Cytoxic Isatin Model Systems, Lidia Matesic, Julie Locke, Kara Perrow, Marie Ranson, John Bremner, Danielle Skropeta
Danielle Skropeta
In this study a series of isatin-based, pH-sensitive aryl imine derivatives with differing aromatic substituents and substitution patterns were synthesised and their acid-catalysed hydrolysis evaluated. These derivatives were functionalised at the C3 carbonyl group of a potent N-substituted isatin cytotoxin and were stable at physiological pH but readily cleaved at pH 4.5. Observed rates of hydrolysis for the embedded imine-acid moiety were in the order para-phenylpropionic acid>phenylacetic acid (para>meta)>benzoic acid (meta>para). The ability to fine-tune hydrolysis rates in this way has potential implications for optimising imine linked, tumour targeting cytotoxin-protein conjugates
Sharing Quality Resources For Teaching And Learning: A Peer Review Model For The Altc Exchange In Australia, Geraldine Lefoe, Robyn Philip, Meg O'Reilly, Dominique Parrish
Sharing Quality Resources For Teaching And Learning: A Peer Review Model For The Altc Exchange In Australia, Geraldine Lefoe, Robyn Philip, Meg O'Reilly, Dominique Parrish
Geraldine Lefoe
The ALTC Exchange (formerly the Carrick Exchange), is a national repository and networking service for Australian higher education. The Exchange was designed to provide access to a repository of shared learning and teaching resources, work spaces for team members engaged in collaborative projects, and communication and networking services. The Australian Learning and Teaching Council (ALTC) established the Exchange for those who teach, manage and lead learning and teaching in higher education. As part of the research conducted to inform the development of the Exchange, models for peer review of educational resources were evaluated. For this, a design based research approach …
Assessing Soil Remobilisation In Catchments Using A 137 Cs-Sediment Hillslope Model, Ava D. Simms, Colin D. Woodroffe, Brian G. Jones, Henk Heijnis, Jennifer Harrison, Rob Mann
Assessing Soil Remobilisation In Catchments Using A 137 Cs-Sediment Hillslope Model, Ava D. Simms, Colin D. Woodroffe, Brian G. Jones, Henk Heijnis, Jennifer Harrison, Rob Mann
B. G. Jones
Soil redistribution studies are important, especially in water supply catchments, because the rate at which denudation is occurring has implications for offsite water quality. However, the extent to which soil is redistributed within the landscape can be difficult to determine. This challenge can be overcome using fallout caesium-137 (137Cs). This paper describes the rates of soil loss and remobilisation in two sub-catchments within the Sydney Basin region, namely Kembla and Kentish Creeks, which drain to the Cordeaux reservoir. The total inventories of 137Cs in catchment soils were determined, a 137Cs-regression equation and a theoretical diffusion and migration model were used …
Collaborative Recovery: An Integrative Model For Working With Individuals Who Experience Chronic And Recurring Mental Illness, Lindsay G. Oades, Frank P. Deane, Trevor P. Crowe, Gordon Lambert, David Kavanagh, Christopher Lloyd
Collaborative Recovery: An Integrative Model For Working With Individuals Who Experience Chronic And Recurring Mental Illness, Lindsay G. Oades, Frank P. Deane, Trevor P. Crowe, Gordon Lambert, David Kavanagh, Christopher Lloyd
Lindsay G Oades
Objectives: Recovery is an emerging movement in mental health. Evidence for recovery-based approaches is not well developed and approaches to implement recovery-oriented services are not well articulated. The collaborative recovery model (CRM) is presented as a model that assists clinicians to use evidencebased skills with consumers, in a manner consistent with the recovery movement. A current 5 year multisite Australian study to evaluate the effectiveness of CRM is briefly described. Conclusion: The collaborative recovery model puts into practice several aspects of policy regarding recovery-oriented services, using evidence-based practices to assist individuals who have chronic or recurring mental disorders (CRMD). It …