Social and Behavioral Sciences Commons^™

Emulsion-Coaxial Electrospinning: Designing Novel Architectures For Sustained Release Of Highly Soluble Low Molecular Weight Drugs, Lucie Viry, Simon E. Moulton, Tony Romeo, Courtney Suhr, Damia Mawad, Mark Cook, Gordon G. Wallace

Faculty of Science - Papers (Archive)

In drug therapy, most therapeutic drugs are of low molecular weight and could freely diffuse in the biological milieu depending on the administration route applied. The main reason for the development of polymeric drug carriers is to obtain desired effects such as sustained therapy, local and controlled release, prolonged activity and reduction of side effects. Alternatively, polymeric carriers can be made bioerodible in order to be eliminated by natural ways after a certain time of therapy. Core-shell fibres from coaxial spinneret or emulsion electrospinning are good candidates for the development of such devices; however difficulties remain especially in controlling the …

Remote Sensing Of Co2 And Ch4 Using Solar Absorption Spectrometry With A Low Resolution Spectrometer, C Petri, T Warneke, N Jones, T Ridder, J Messerschmidt, T Weinzierl, M Geibel, J Notholt

Faculty of Science - Papers (Archive)

Throughout the last few years solar absorption Fourier Transform Spectrometry (FTS) has been further developed to measure the total columns of CO2 and CH4. The observations are performed at high spectral resolution, typically at 0.02 cm(-1). The precision currently achieved is generally better than 0.25%. However, these high resolution instruments are quite large and need a dedicated room or container for installation. We performed these observations using a smaller commercial interferometer at its maximum possible resolution of 0.11 cm(-1). The measurements have been performed at Bremen and have been compared to observations using our high resolution instrument also situated at …

The Interaction Of Body Armor, Low-Intensity Exercise, And Hot-Humid Conditions On Physiological Strain And Cognitive Function, Joanne N. Caldwell, Lian Engelen, Charles Van Der Henst, Mark J. Patterson, Nigel A.S Taylor

Faculty of Health and Behavioural Sciences - Papers (Archive)

Objective: This project was aimed at evaluating the impact of combat armor on physiological and cognitive functions during low-intensity exercise in hot-humid conditions (36°C and 60% relative humidity). Methods: Nine males participated in three trials (2.5 hours), walking at two speeds and wearing different protective equipment: control (combat uniform and cloth hat); torso armor with uniform and cloth hat; and full armor (uniform, torso armor, and helmet). Results: As time progressed, core temperatures increased and deviated signifi cantly among trials, rising at 0.37°C h −1 (control), 0.41°C h −1 (torso armor), and 0.51°C h −1 (full armor). Heart rates also …

Soils Of Low Elevation Coral Structures, John Morrison

Faculty of Science - Papers (Archive)

The small islands of the South Pacific region, like many other parts of the world, arc (~\I\j riencing population growth and, more particularly, the movement of people into )11,1I1!1 urban centres. Most Pacific cities, especially the capitals of regional countries, arc locili ",I in naturally protected coastal waterways. This is a historical situation, arising from III,' need to provide protected deep-water harbours for ships, the main form of internaliol\,d travel and trade. These waters are protected by offshore barrier reefs, by islands or by ril(,1 ine deltas. However, these protective mechanisms also have the effect of limiting mix!II): of near-shore …

Reaction Of The C2h Radical With 1-Butyne (C4h6): Low Temperature Kinetics And Isomer-Specific Product Detection, Satchin Soorkia, Adam J. Trevitt, Talitha M. Selby, David L. Osborn, Craig A. Taatjes, Kevin R. Wilson, Stephen R. Leone

Faculty of Science - Papers (Archive)

No abstract provided.

Effects Of High And Low Breast Support On Breast Kinematics And Kinetics During Treadmill Running, Deirdre Mcghee, Julie R. Steele, William J. Zealey

Faculty of Health and Behavioural Sciences - Papers (Archive)

Results: The mean vertical component of the peak bra/breast spring force during treadmill running was greatest during the downward breast trajectory and was approximately 30% less in the high breast support condition (13 N ± 7 N) compared to the low support condition (17 N ± 10 N). This force reduction was accompanied by a 300% decrease in breast and bra discomfort. Conclusion: Wearing a well-fitted supportive sports bra is recommended for females with large breasts to reduce the breast forces and, in tum, exercise induced breast and bra discomfort during physical activity such as treadmill running.

Reactions Of The Cn Radical With Benzene And Toluene: Product Detection And Low-Temperature Kinetics, Adam J. Trevitt, Fabien Goulay, Craig A. Taatjes, David L. Osborn, Stephen R. Leone

Faculty of Science - Papers (Archive)

Low-temperature rate coefficients are measured for the CN + benzene and CN + toluene reactions using the pulsed Laval nozzle expansion technique coupled with laser-induced fluorescence detection. The CN + benzene reaction rate coefficient at 105, 165, and 295 K is found to be relatively constant over this temperature range, (3.9−4.9) × 10−10 cm3 molecule−1 s−1. These rapid kinetics, along with the observed negligible temperature dependence, are consistent with a barrierless reaction entrance channel and reaction efficiencies approaching unity. The CN + toluene reaction is measured to have a rate coefficient of 1.3 × 10−10 cm3 molecule−1 s−1 at 105 …

Multiresonator-Based Chipless Rfid System For Low-Cost Item Tracking, Stevan Preradovic, Isaac Balbin, Nemai Karmakar, Gerhard F. Swiegers

Faculty of Science - Papers (Archive)

A fully passive printable chipless RFID system is presented. The chipless tag uses the amplitude and phase of the spectral signature of a multiresonator circuit and provides I : 1 correspondence of data bits. The tag comprises of a microstrip spiral multiresonator and cross-polarized transmitting and receiving microstrip ultra-wideband disc loaded monopole antennas. The reader antenna is a log periodic dipole antenna with average 5.5-dBi gain. Firstly, a 6-bit chipless tag is designed to encode 000000 and 010101 IDs. Finally, a 35-bit chipless tag based on the same principle is presented. The tag has potentials for low-cost item tagging such …

Nmr Study Of Complexes Between Low Molecular Mass Inhibitors And The West Nile Virus Ns2b-Ns3 Protease, X Su, Kiyoshi Ozawa, Hiromasa Yagi, S P. Lim, D Wen, D Ekonomiuk, D Huang, T Keller, S Sonntag, A Caflisch, S G. Vasudevan, G Otting

Faculty of Science - Papers (Archive)

The two-component NS2B-NS3 protease of West Nile virus is essential for its replication and presents an attractive target for drug development. Here, we describe protocols for the high-yield expression of stable isotope-labelled samples in vivo and in vitro. We also describe the use of NMR spectroscopy to determine the binding mode of new low molecular mass inhibitors of the West Nile virus NS2B-NS3 protease which were discovered using high-throughput in vitro screening. Binding to the substrate-binding sites S1 and S3 is confirmed by intermolecular NOEs and comparison with the binding mode of a previously identified low molecular mass inhibitor. Our …

Aripiprazole Differentially Affects Mesolimbic And Nigrostriatal Dopaminergic Transmission: Implications For Long-Term Drug Efficacy And Low Extrapyramidal Side-Effects, Xu-Feng Huang, Chao Deng, Mei Han

Faculty of Health and Behavioural Sciences - Papers (Archive)

Aripiprazole has been used effectively to treat schizophrenia in the clinic ; however, its mechanisms ofaction are not clear. This study examined how short- and long-term aripiprazole treatment affects dopaminergic transmission in mesolimbic and nigrostriatal pathways. For comparison, the effects of haloperidol and olanzapine treatment were also examined. Aripiprazole significantly increased D2 receptor mRNA expression and decreased tyrosine hydroxylase (TH) mRNA expression in the ventral tegmental area (VTA) after 1- and 12-wk treatment, but had no effect in substantia nigra (SN) and nucleus accumbens (NAc). Aripiprazole also decreased dopamine transporter (DAT) binding density in NAc (for 1- and 12- wk …

Automatic Reaction To A Chemical Event Detected By A Low-Cost Wireless Chemical Sensing Network, Stephen Beirne, King Tong Lau, Brian Corcoran, Dermot Diamond

Faculty of Science - Papers (Archive)

A test-scale wireless chemical sensor network (WCSN) has been deployed within a controlled Environmental Chamber (EC). The combined signals from the WCSN were used to initiate a controllable response to the detected chemical event. When a particular sensor response pattern was obtained, a purging cycle was initiated. Sensor data were continuously checked against user-defined action limits, to determine if a chemical event had occurred. An acidic contaminant was used to demonstrate the response of the sensor network. Once the acid plume was simultaneously detected by a number of wireless chemical sensor nodes, an automatic response action, which was the purging …

A Food-Based Dietary Strategy Lowers Blood Pressure In A Low Socio-Economic Setting: A Randomised Study In South Africa, Karen E. Charlton, Naomi Levitt, Krisela Steyn, Deborah Jonathan, Nomonde Gwebushe, Nasheeta Peer, Katja Rossouw, Theresa Gogela, Carl J. Lombard

Faculty of Health and Behavioural Sciences - Papers (Archive)

Objective To assess the impact of a food-based intervention on blood pressure (BP) in free-living South African men and women aged 50–75 years, with drug-treated mild-to-moderate hypertension.

Methods A double-blind controlled trial was undertaken in eighty drug-treated mild-to-moderate hypertensive subjects randomised to an intervention (n 40) or control (n 40) arm. The intervention was 8-week provision of six food items with a modified cation content (salt replacement (SOLO™), bread, margarine, stock cubes, soup mix and a flavour enhancer) and 500 ml of maas (fermented milk)/d. The control diet provided the same quantities of the targeted foods but of …

Chemical Event Tracking Using A Low-Cost Wireless Chemical Sensing Network, Stephen T. Beirne, B Corcoran, K T Lau, D Diamond

Faculty of Science - Papers (Archive)

A recently developed low-cost light emitting diode (LED) chemical sensing technique is integrated with a Mica2Dot wireless communications platform to form a deployable wireless chemical event indicator network. The operation of the colorimetric sensing node has been evaluated to determine its reproducibility and limit of detection for an acidic airborne contaminant. A test-scale network of five similar chemical sensing nodes is deployed in a star communication topology at fixed points within a custom built Environmental Sensing Chamber (ESC). Presented data sets collected from the deployed wireless chemical sensor network (WCSN) show that during an acidic event scenario it is possible …

Evaluation Of A Low Cost Wireless Chemical Sensor Network For Environmental Monitoring, Jer Hayes, Stephen Beirne, King-Tong Lau, Dermot Diamond

Faculty of Science - Papers (Archive)

We present work on the development and testing of a low-cost wireless chemical sensor network (WCSN) for monitoring irritant/toxic gases in the environment. The WCSN used in this work takes advantage of recent advances in low power wireless communication platforms and uses colorimetric sensors to detect the presence of certain target gases. This sensor network adopts a star configuration and performs one way RF communications from individual sensor nodes to the base-station. Each node in the network is composed of a multiple sensor platform that measures light intensity, temperature and motion. The light sensor was used as the chemical sensing …

Prevalence Of Low Serum Folate And Vitamin B12 In An Older Australian Population, Victoria M. Flood, Wayne T. Smith, Karen L. Webb, Elena Rochtchina, Valerie Anderson, Paul Mitchell

Faculty of Health and Behavioural Sciences - Papers (Archive)

Objective: To examine the prevalence of low serum folate and vitamin B12, in association with elevated serum homocysteine, in a representative sample of older Australians. Methods: During 1997-2000, 3,508 persons aged 50+ years were examined in a population-based cohort study conducted in two postcodes, west of Sydney, Australia. Of these, 2,901 participants (82.7%) provided fasting blood for estimates of serum folate, vitamin B12 and total homocysteine. Results: Low serum B12 (<185 pmol>/L) was found in 22.9% of participants and low serum folate (<6.8 nmol/L) in 2.3% of participants. Among those people with very low serum vitamin B12 (<125 pmol/L) and low serum folate, 51% had elevated homocysteine. Conclusions: Low serum levels of vitamin B12 and elevated serum homocysteine are relatively frequent in older Australians. Implications: Appropriate public health action should be considered to reduce the prevalence of low serum vitamin B12 and elevated homocysteine in older Australians.

Low-Dose/High-Concentration Localized Botulinum Toxin A Improves Upper Limb Movement And Function In Children With Hemiplegic Cerebral Palsy, Kevin Lowe, Iona Novak, Anne Cusick

Faculty of Health and Behavioural Sciences - Papers (Archive)

The objective was to determine the effects of low-dose, highconcentration, dual localized botulinum toxin A (BTX-A) injections on upper limb movement quality and function. Study design was an evaluator-blinded, randomized, controlled trial. Forty-two children (31 males, 11 females; range 2–8y, mean 4y [SD 1.6]) with hemiplegic cerebral palsy (Gross Motor Function Classification System level I)participated. All received occupational therapy. The treatment group (n=21) received one injection series (mean muscles injected 6 [SD 1.05]; total dose 82–220 units, mean 139 [SD 37.48]; dilution 100 units/0.5ml). Primary outcome of Quality of Upper Extremity Skills Test (QUEST) at 6 months was not significant …

The Effect Of A Low Glycemic Index Diet During Pregnancy On Obstetric Outcomes, Robert G. Moses, M J. Luebcke, Warren S. Davis, K J. Coleman, Linda C. Tapsell, Peter Petocz, Jennie C. Brand-Miller

Faculty of Health and Behavioural Sciences - Papers (Archive)

Abstract presented at The 2006 Annual Scientific Meeting of the Nutrition Society of Australia, 29 November - 2 December, Sydney, Australia

Low And High Trait Impulsiveness In The Stop-Signal Task: Underlying Differences In Erps But Not Performance, Aneta Dimoska, Stuart J. Johnstone

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.